The Limestone Saints are the athletic teams that represent Limestone College, located in Gaffney, South Carolina, in NCAA Division II intercollegiate sporting competitions.

The Saints compete as members of Conference Carolinas for most sports, which Limestone has been a member of since 1998. The swim team competes with the Bluegrass Mountain Conference, and the field hockey and wrestling teams are members of ECAC Division II.

The football team competes as an independent, but has a scheduling agreement (2015-2018) with the South Atlantic Conference.