Sydney Wiese and Gabriella Hanson each scored 13 points as No. 2 seed and host Oregon State reached the NCAA Tournament's Sweet 16 with a 64-52 second-round victory over Creighton on Sunday at Gill Coliseum in Corvallis, Ore.
Marie Gulich added 12 points and 12 rebounds as the Beavers (31-4) moved closer to a second straight trip to the Final Four.
Sydney Lamberty had 19 points while Brianna Rollerson added 10 as No. 7 seeded Creighton (24-8) saw a four-game series winning streak against Oregon State snapped.
Oregon State meets No. 3 seed Florida State on Saturday in Stockton (Calif.) Region play. The Seminoles, who beat Missouri 77-55 earlier Sunday, are in the Sweet 16 for the third straight season.
The Beavers never trailed in the game, led 17-10 after the opening quarter and expanded the advantage to 39-27 by halftime thanks, in part, to Hanson's 11 points.
A Wiese 3-pointer and Kolbie Orum's layup pushed Oregon State's lead to 50-35 with 3:07 left in the third quarter. Creighton twice crept back to within 10 and trailed 52-42 by quarter's end thanks to Rollerson's jumper with 1:01 left.
Creighton closed to within six points at 54-48 on Lamberty's layup with 6:42 left in regulation, but the Bluejays never got any closer.
Oregon State shot 26 of 61 from the field (42.6 percent) and outrebounded Creighton 45-32. The Bluejays were 22 of 60 (36.7 percent) from the field and hit just 2 of 10 shot from 3-point range.
Creighton shared the Big East regular-season championship with DePaul but fell in the conference tournament semifinals to eventual champion Marquette.
The Bluejays were appearing in their sixth NCAA Tournament and bidding to reach the Sweet 16 for the first time. They beat Toledo 76-49 in Friday's opening round.
Oregon State, which reached the Final Four last season, was the Pac-12 regular-season champion and tournament runner-up after falling to Stanford in the conference title game.
The Beavers, making their ninth NCAA Tournament appearance, survived a scare by escaping with a 56-55 first-round victory over No. 15 seed Long Beach State.