Tagovailoa appeared to be done for the afternoon with the Tide (9-1, 6-1 Southeastern Conference) leading 35-7, but he returned with 3:42 left in the second quarter and suffered a season-ending dislocated hip as he was tackled under a heavy rush on third down. He completed his first eight pass attempts and was 14-of-18 passing for 256 yards and a pair of touchdowns before leaving.
Sophomore Mac Jones took over for Tagovailoa and completed 7 of 11 passes for 94 yards in the second half, but the Tide added only a field goal to their halftime bulge.
Running back Najee Harris scored a career-high four touchdowns, three of them rushing, while rushing for 88 yards as the Tide ran their winning streak against the Bulldogs to 12 consecutive games.
Joe Burrow continued his record-shattering season by throwing five touchdown passes as the Tigers outlasted the host Rebels.
Burrow, the presumed Heisman Trophy favorite, completed 32 of 42 passes for 489 yards, but he also had two fourth-quarter interceptions that helped Ole Miss (4-7, 2-5) stay in the game. Still, the Rebels never got closer than 11 points in the second half.
LSU (10-0, 6-0) rolled to a 31-7 halftime lead behind Burrow's three touchdown passes. The Tigers can lock up the SEC West with a victory over Arkansas next week.
Turnovers on their first two possessions ruined any hopes for the Scarlet Knights, as Justin Fields threw four touchdown passes to lead the Buckeyes to an easy victory in Piscataway, N.J.
An interception and a fumble led to a 14-0 lead for Ohio State (10-0, 7-0 Big Ten) in the opening 3:36 on an 18-yard run by J.K. Dobbins (89 yards, two touchdowns on 17 carries) and an 11-yard catch by Binjimen Victor for the first of his two TDs.
Fields threw for a career best 305 yards on 15-of-19 passing. He has 31 TDs and one interception this season. Sophomore receiver Chris Olave set a career high with 139 yards on four catches. Rutgers (2-8, 0-7) quarterback Johnny Langan was 12 for 26 for 121 yards, an interception and a 45-yard TD pass to Bo Melton late in the third quarter.
Quarterback Trevor Lawrence threw four touchdown passes, and the Tigers rolled past the visiting Demon Deacons in an Atlantic Coast Conference game at Memorial Stadium.
Clemson, which already had clinched a fifth consecutive Atlantic Division title and berth in the ACC Championship Game, improved to 11-0 overall and 8-0 in league play, capping its second straight unbeaten season in the ACC.
The Tigers have won 26 consecutive games and haven't lost to an ACC opponent since a 27-24 loss at Syracuse on Oct. 13, 2017. Wake Forest fell to 7-3, 3-3.
The Bulldogs are headed back to the SEC Championship for the third straight year after bouncing the Tigers on the road.
Georgia (9-1, 6-1 SEC) made the score 21-0 on a 5-yard touchdown pass with 13 seconds left in the third quarter to tight end Eli Wolf from Jake Fromm, who completed only 13 of 28 passes for 110 yards, but accounted for all three Bulldogs scores with a trio of scoring passes.
The Tigers (7-3, 4-3) made Georgia sweat. Auburn trailed 21-0 heading into the fourth but roared back with a pair of scores. The Tigers were driving for the tying touchdown until a fourth-down pass from Bo Nix sailed through the arms of Harold Joiner to give the football back to Georgia with 2:24 to play.
Tyler Huntley passed for two touchdowns and rushed for a third, Zack Moss ran for two scores, and the Utes routed the visiting Bruins in Salt Lake City.
Utah (9-1, 6-1 Pac-12 Conference) surrendered a field goal on UCLA's game-opening possession. The Utes proceeded to score the game's next 49 points, beginning on the next drive when Huntley ran for a 2-yard touchdown.
UCLA (4-6, 4-3) moved the ball into Utah territory for a third time in the early going, following the initial 43-yard J.J. Molson field goal and a 42-yard miss. Trailing 14-3 after a 4-yard Moss touchdown rush, the Bruins had an opportunity to pull back within single digits. However, UCLA quarterback Dorian Thompson-Robinson coughed up a fumble that Utah's Mika Tafua returned 68 yards for a touchdown, kicking off the blowout in earnest.
Nate Stanley passed for 173 yards and two touchdowns, and freshman Tyler Goodson rushed for 94 yards and one touchdown in his first start as the host Hawkeyes knocked the Golden Gophers from the unbeaten ranks in Iowa City.
Iowa (7-3, 4-3) scored touchdowns on its first three possessions for a quick 20-3 lead, then used its top-20 defense to hold off a late charge led by Gophers quarterback Tanner Morgan, who passed for 368 yards and a touchdown.
Down 23-19, Minnesota (9-1, 6-1) took over on its own 20-yard line with 1:52 remaining. Morgan was sacked on the first two plays, and was forced to leave the game with an apparent left leg injury after the second. Cole Kramer entered and threw an incomplete pass, and then was intercepted on fourth-and-21 with 46 seconds remaining.
Quarterback Sean Clifford accounted for three touchdowns to lead the Nittany Lions to a victory over the Hoosiers in University Park, Pa.
Clifford completed 11 of 23 passes for 179 yards and a score, and the sophomore rushed for 55 yards and two touchdowns. Journey Brown carried 21 times for 100 yards and a score for the Nittany Lions.
Indiana junior Peyton Ramsey, in his fourth start this season but first since freshman Michael Penix Jr. was ruled out for the season with an injury, completed 31 of 41 passes for a career-high 371 yards and a touchdown. He added two rushing scores for the Hoosiers, who had a four-game winning streak snapped.
Down by 25 points in the second quarter, the Sooners lashed together a stunning rally, dominating the Bears in the second half to win in Waco, Texas.
The Sooners (9-1, 6-1 Big 12) kept their slim hopes of reaching the College Football Playoff alive with their comeback. Redshirt freshman kicker Gabe Brkic capped the biggest comeback in program history by converting a 31-yard field goal with 1:45 left in the game.
The Bears (9-1, 6-1) had another chance, but their final possession ended with Nik Bonitto intercepting Baylor quarterback Charlie Brewer at the Oklahoma 38-yard line with 29 seconds remaining.
Kyle Trask threw two third-quarter touchdown passes to help the Gators pull away from the Tigers in Columbia, Mo.
Trask, a redshirt junior, was 23 of 35 for 282 yards with scoring passes to Josh Hammond and Lamical Perine. Evan McPherson kicked field goals of 47, 39 and 22 yards for the Gators (9-2, 6-2).
The Tigers (5-5, 2-4) lost their fourth straight game but their first in six home games. They have not scored a touchdown in the past nine quarters. Missouri's Kelly Bryant finished 25 of 39 for 204 yards with one interception after missing last week's loss at Georgia due to a hamstring injury suffered two weeks earlier at Kentucky.
Jonathan Taylor ran for 204 yards and two touchdowns as the Badgers reeled off 24 straight points in a win over the Cornhuskers in Lincoln, Neb.
Taylor, a junior, carried 25 times to notch his third career 200-yard rushing performance against the Cornhuskers.
Taylor's 11-yard run late in the third quarter moved him past Ohio State's Archie Griffin (5,589 yards) to rank second in career rushing yardage in Big Ten history. Wisconsin's Ron Dayne is the all-time conference leader with 7,125 yards. Early in the fourth quarter, Taylor also passed Georgia's Herschel Walker (5,596) for the most rushing yards by a player by the end of his junior season. Taylor is up to 5,634 yards.
Shea Patterson passed for 384 yards and four touchdowns as the Wolverines overwhelmed the visiting Spartans in Ann Arbor, Mich.
Patterson completed 24 of 33 passes, and Ronnie Bell caught nine passes for 150 yards for the Wolverines (8-2 overall, 5-2 Big Ten). Brian Lewerke completed 17 of 30 passes for 166 yards and one touchdown for Michigan State (4-6, 2-5), which has lost five straight. Lewerke was also picked off twice.
The Wolverines led 17-7 at halftime. An Ambry Thomas interception set up another Michigan touchdown early in the second half, with Patterson connecting with Donovan Peoples-Jones on an 18-yard scoring pass.
Ian Book completed 14 of 20 passes for 284 yards and five touchdowns, including four to wide receiver Chase Claypool, and the Fighting Irish cruised over the visiting Midshipmen in South Bend, Ind.
Wide receiver Braden Lenzy also hauled in a touchdown pass from Book, and running back Tony Jones Jr. tallied a touchdown on the ground. Notre Dame (8-2) won its third game in a row and improved to 6-0 at home.
Mychal Cooper caught a 43-yard touchdown for Navy (7-2), whose five-game winning streak came to an end. The Midshipmen committed four turnovers that led to 28 points for the Fighting Irish.
Brady White passed for 341 yards and five touchdowns to lead the visiting Tigers victory past the host Cougars in an American Athletic Conference game.
White completed 22 of 33 passes and had one interception. He also rushed for a touchdown. Kenneth Gainwell had 99 yards on 17 carries.
Three of the Tigers' receivers had more than 80 yards receiving -- Calvin Austin III (five catches for 81 with a touchdown), Damonte Coxie (four for 93 with two touchdowns) and Antonio Gibson (four for 93 with a touchdown). The Tigers (9-1, 5-1 AAC) have won four consecutive games while Houston (3-7, 1-5) has lost three straight games.
Sophomore running back Chuba Hubbard, the nation's leading rusher, carried 23 times for 122 yards as the Cowboys toppled the Jayhawks in Stillwater, Okla.
The victory for the Cowboys (7-3, 4-3 Big 12), spoiled the return of Les Miles, the first-year Kansas coach who guided Oklahoma State for four seasons (2001-04) before accepting the head coach's position at LSU.
Cowboys starting quarterback Spencer Sanders left the game in the third quarter after aggravating a thumb injury. He passed for 168 yards and one touchdown. Kansas quarterback Carter Stanley passed for 226 yards.
The Mountaineers scored the final 10 points of the game and held off a last-minute Wildcats drive to earn the win in Manhattan, Kan.
The Mountaineers (4-6, 2-5 Big 12) snapped a five-game losing streak and kept their bowl hopes alive. It was West Virginia's fourth straight victory against K-State (6-4, 3-4).
Kansas State took over at its 8-yard line with 2:53 left in the game and two timeouts. The Wildcats drove to the West Virginia 30 with 35 seconds left, but defensive back Hakeem Bailey intercepted Skylar Thompson at the 3 to seal the victory.
Zac Thomas threw four touchdown passes, three to Corey Sutton, and the Mountaineers scored 49 consecutive points en route to a rout of the Panthers in Atlanta.
The victory allowed the Mountaineers (9-1, 5-1 Sun Belt) to maintain a one-game East Division lead ahead of Georgia Southern, a 51-29 winner against University of Louisiana Monroe earlier in the day.
Thomas completed 19 of 31 attempts for 256 yards with one interception in little more than three quarters before sitting. Georgia State (6-4, 3-3) dropped its second straight game and fell two games behind Appalachian State in the East Division.