Washington Redskins interim coach Bill Callahan didn't know the severity of Derrius Guice's knee injury on Monday afternoon, but it's significant enough to already rule out the running back for Sunday's home game against the Philadelphia Eagles.
Callahan also said veteran linebacker Ryan Kerrigan won't play this week. He left in the third quarter of Sunday's 20-15 loss to the Green Bay Packers with a calf injury.
Guice did not return after leaving in the second quarter when he took a hit from safety Darnell Savage Jr. to his left knee at the end of a 23-yard gain. Guice was scheduled for an MRI exam Monday.
Guice was playing in his fourth game since being activated off injured reserve. He had been sidelined since sustaining a torn meniscus in his right knee during Washington's season-opening 32-27 loss against the Eagles on Sept. 8.
The 22-year-old, who was a second-round pick of the 2018 NFL Draft, missed his entire rookie season with a torn left ACL.
Guice was coming off his best game as a pro, gaining 129 yards with two scores on 10 carries in a win over the Carolina Panthers on Dec. 1. He has 42 rushes for 245 yards and two touchdowns in five games this season.
Veteran running back Adrian Peterson will remain the Redskins' primary back. He has 167 carries for 718 yards this season, and on Sunday became the sixth player in NFL history to top 14,000 career rushing yards.