2022 Buffalo Bills Win Total Odds and Picks

The Buffalo Bills enter the 2022 season with a ton of optimism, and this franchise continues to trend in the right direction. Buffalo was in the playoffs a season ago but came up just short in an epic playoff matchup.

NFL Sportsbooks

The Bills are set to enter the 2022 season as one of the betting favorites to win the Super Bowl, but they will have plenty of competition. The regular season win totals are set, and the betting lines and odds are open.

Buffalo Bills Regular Season Win Total Betting Lines

Over 11.5 Wins (-135)

Under 11.5 Wins (+115)

Last Season

The Buffalo Bills had a tough time during the 2021 season, and it looked as if they weren’t going to win the AFC East until the very end of the year. A dominant performance over the New England Patriots late in the year allowed them to win the AFC East, and that set them up for a big run in the playoffs.

Buffalo ended its season with an overtime loss to the Kansas City Chiefs in one of the best NFL Playoff games of all time.

NFL Odds

Bills Key Losses Heading Into 2022

One of the reasons that the Bills have such high expectations heading into 2022 is that they didn’t lose a ton of talent this offseason. Backup quarterback Mitch Trubisky has gone, but he never saw much action during the games.

Defensive tackle Harrison Phillips is the biggest loss as he has signed a deal with the Minnesota Vikings. Cornerback Levi Wallace has also moved on, and that could hurt the secondary.

2022 Buffalo Bills Team Preview

Everything starts and ends with quarterback Josh Allen for the Buffalo Bills. This offense runs through Allen, but he has so many talented weapons on each side of him.

The defense for Buffalo often gets overlooked, but that secondary is one of the best in the NFL. If the Bills are going to get great work from that defense, then they are going to be hard to beat during the 2022 season.

NFL Picks

2022 Buffalo Bills Team Schedule

The 2022 season for the Bills starts off in Los Angeles against the Rams, and the schedule really doesn’t get much easier. Buffalo has a tough schedule in 2022, but they play in an AFC East Division in which they should dominate.

Besides the Week 1 road game against the Rams, the Bills also play at the Kansas City Chiefs and host the Green Bay Packers.

2022 Bills Regular Season Win Total Prediction

There is no doubt that the Buffalo Bills are on a mission in the 2022 season as they want to make up for the disappointing end to the 2021 season. Buffalo does face a difficult schedule in 2022, but this team is simply loaded on both sides of the ball.

The best team in the NFL is going to win at least 12 games in 2022, and the Bills are that team. Take the Bills over 11.5 wins as they win the AFC East and enter the playoffs with a ton of momentum.

Pick: Over 11.5 Wins (-135)