The Patriots looked like a machine and the Dolphins appeared to be lost at sea in Week 1, leading oddsmakers to push New England as a big favorite in opening lines for Week 2.
The Dolphins get a second home game, but the venue appears to be of little significance with the Patriots opening as 17 1/2-point favorites at the majority of Las Vegas sportsbooks.
Miami has won five of the past six games against the Patriots at Hard Rock Stadium in Miami Gardens, Fla., including 34-33 in 2018. The last time New England won by more than two touchdowns at Miami was 2010, a 41-14 landslide.
After putting up 33 points against the Steelers on Sunday night, the Patriots are likely to put up some points in Florida against a lesser defense. The over-under was set at 47 1/2 at MGM and Westgate.
Last week's opponent, the Baltimore Ravens, splashed a league-high 59 points on Miami.
The Ravens are huge favorites in Week 2 -- 13 1/2 points over the Arizona Cardinals -- at Westgate.
Kansas City (-9.5 at Oakland) and Houston (-9.5 against Jacksonville) also opened as big favorites in Vegas on Week 2 opening lines.