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Los Angeles Rams vs. Arizona Cardinals Pick & Prediction SEPTEMBER 25th 2022

Logo Los Angeles Rams
Logo Arizona Cardinals

-3.5 +101
51o -110



An NFC West battle is set to take place, as the Los Angeles Rams face the Arizona Cardinals. The Rams earned their first win of the season in week 2 by beating the Atlanta Falcons. That game showcased the Rams offense that we didn’t see in week 1. Their 31-27 win over Atlanta should give them a bit of momentum as well. We’ll have to see how they hold up in week 3.

The Arizona Cardinals battled back in week 2 to earn a win over the Las Vegas Raiders. After earning a 29-23 victory on the road, the Cardinals head back home to face the Rams. This isn’t going to be an easy game for Arizona. Facing Aaron Donald and Jalen Ramsey could be a nightmare for Kyler Murray. Can the Cardinals offense be good enough to face this challenge?

Rams vs. Cardinals Odds


MONEY LINE: Rams (-175) vs. Cardinals (+155)

SPREAD: Rams -3.5 (-112) vs. Cardinals +3.5 (-108)

GAME TOTAL: Over 48.5 (-110) vs. Under 48.5 (-110)

Rams vs. Cardinals Preview, Trends and Stats

Although the Los Angeles Rams earned a win last week, there is something we’re concerned about. Known as one of the best defensive units, the Rams have given up an average of 29 points per game. They rank as the fourth-worst team in this category in the entire NFL.

They’re playing Arizona, a team they’re familiar with, sure. Still, the Cardinals offense has looked great this season and the Rams defense hasn’t. They allowed the Falcons to score 27 last week and the Buffalo Bills scored 31 in the prior week. Be sure to consider this when betting.

Offensively, the Los Angeles Rams have picked up the speed. Matthew Stafford still seems to struggle with throwing interceptions, however. Last week, Stafford went 27/36, passing for 272 yards with three touchdowns and two interceptions. He’s thrown a total of five already this year.

The Cardinals have likely watched hours of tape on Stafford’s interceptions. Because of this, we think their defense is going to do rather well against Los Angeles. The question is, how will their offense perform? The good news is they’re at home, so they won’t have any outside deterrents.

In week 2, the Cardinals showed resilience, battling back from a 17-0 deficit. In the fourth quarter alone, the Cardinals scored 16 unanswered points, tying the game. From there, they beat the Raiders in overtime with a 59-yard fumble return, a fitting end to a great game.

Heading into this game, there’s one player for the Cardinals to make sure is guarded. Cooper Kupp is the leading receiver for the Rams, earning three touchdowns over two games. If the Cardinals can make him a non-factor, they should be able to come away with a win.

Rams vs. Cardinals Predictions

This is the Los Angeles Rams first game on the road this season. Considering it’s a divisional game, the stakes are ramped up quite a bit. Now, the Rams nearly allowed the Falcons to rally back last week, letting them score 17 unanswered points. Something is going wrong with their defense, which is why we’re taking the Cardinals on Sunday.

Arizona comes into this game as 3.5-point underdogs, odds that we definitely like. After their win over the Raiders, we think the Cardinals could be the team to beat in the NFC West. They don’t have a great record against the Rams in the past, but it’s a new season. The Rams defense looks slow and Stafford has thrown a lot of interceptions.

Final Score: 28-24 (Cardinals)


1. The Los Angeles Rams are 1-4 against the spread in their last five games.

2. The total has gone OVER in 4 of Arizona's last 6 games against the Rams.

3. WR Van Jefferson (Rams) is listed as “questionable” with a knee injury.

Best Bet: Arizona Cardinals +3.5 (-108) and Over 48.5 (-110)

Los Angeles Rams
Arizona Cardinals

Los Angeles Rams vs. Arizona Cardinals Recap DEC 6TH 2020

Jared Goff threw for 424 yards and connected on his first touchdown pass in over a month, as the visiting Los Angeles Rams boosted their shrinking playoff hopes by rolling to a 34-7 victory Sunday over the Arizona Cardinals.

Goff threw two touchdowns on the day, his first scoring strikes since Oct. 27 in a victory over the Cincinnati Bengals at London. Tight end Tyler Higbee and wide receiver Cooper Kupp caught scoring passes, as the Rams (7-5) rebounded from a demoralizing 45-6 defeat to the Baltimore Ravens on Monday night.

Cardinals rookie quarterback Kyler Murray was 19 of 34 for 163 yards, was sacked six times and threw an interception in the third quarter that was returned for a touchdown by Rams rookie safety Taylor Rapp.

Murray ran for a 15-yard TD with 8:35 remaining as the Cardinals avoided a shutout with an 80-yard drive. The Cardinals had 81 total yards in the game before that drive started.

The Cardinals (3-8-1) were held to 63 total yards in the first half and 197 in the game while losing for the fifth consecutive time.

Todd Gurley rushed for 95 yards, two short of his season high, as the Rams had a season-best 549 yards of total offense. Wide receiver Robert Woods tied a career-best with 13 receptions for 172 yards, while Higbee caught seven passes for a career-best 107 yards.

The Rams led just 3-0 after one quarter. A 2-yard TD pass from Goff to Higbee, an 11-yard scoring run from Gurley and a 33-yard field goal as time expired in the second quarter gave them a 20-0 lead into halftime.

Kupp caught a 10-yard TD pass from Goff early in the third quarter to boost the lead to 27-0, before Rapp ran back his interception 31 yards for a score two offensive plays later.

Los Angeles' defensive domination was so thorough, the Cardinals did not get inside the Rams' 45-yard line until under 11 minutes remained in the game.

The Rams have one more game remaining against the Cardinals at home, but also have games left on the schedule against the Seattle Seahawks, Dallas Cowboys and San Francisco 49ers. Los Angeles is 1 1/2 games behind the Minnesota Vikings for the second NFC wild card.

--Field Level Media

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