The Mississippi College Choctaws are the athletic teams of Mississippi College. On July 11, 2014 the NCAA approved entering their second year of NCAA Division II candidacy. The Choctaws are in the process of becoming full members of the Gulf South Conference.

The college sponsors teams in football, basketball (men`s and women`s), baseball, softball, tennis (men`s & women`s), golf (men`s & women`s), soccer (women`s), volleyball, track and field (men`s outdoor & women`s indoor & outdoor), cross country running (men`s & women`s), equestrian (women`s), and table tennis (men`s & women`s).

In the second year of transition, the Choctaws compete against members of the Gulf South Conference.