Clemson Tigers vs Cincinnati Bearcats Picks and Predictions December 21st 2025

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The Clemson Tigers enter 9-3 and look to extend their strong nonconference run, while the Cincinnati Bearcats aim to build consistency after a dominant win. Bettors will weigh Clemson’s offensive depth against Cincinnati’s rebounding and perimeter shooting in this neutral-site matchup at Bon Secours Wellness Arena.

Line Movement and Odds

Clemson opened as a slight favorite, with the line reflecting confidence in their overall record. Current market:

  • Clemson Spread: -6.0 (-110)
  • Cincinnati Spread: +6.0 (-110)
  • Clemson MoneyLine: -260
  • Cincinnati MoneyLine: +210
  • Total: 139.5 (-110)

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Matchup Breakdown

Cincinnati Outlook

Cincinnati averages 75.5 points per game, with Baba Miller and Day Day Thomas leading the offense. Their rebounding edge (40.1 per game, 68th nationally) and perimeter shooting (45.9% from three for Thomas) highlight strengths. Their 7-4 record reflects inconsistency, though their recent win over Alabama State shows offensive potential.

Clemson Outlook

Clemson averages 80.7 points per game with Maurice Odum and Ace Buckner providing scoring depth. Their rebounding (40.4 per game) and free-throw accuracy (74%) highlight efficiency. Their 9-3 record and perfect mark as favorites underscore betting confidence, though the loss of Zac Foster impacts backcourt depth.

Key Matchup / Path to Victory

The game hinges on Clemson’s ability to maintain offensive rhythm, while Cincinnati must lean on Miller and Thomas to pace the offense. If Clemson controls tempo and rebounds, their depth should create separation.

Basketball
2025-12-21 13:00
Off Board
Ole Miss Rebels
NC State Wolfpack
Basketball
2025-12-21 15:00
Open
Cincinnati Bearcats
Clemson Tigers
Basketball
2025-12-21 16:30
Open
UConn Huskies
DePaul Blue Demons

Injuries / Availability

Cincinnati: Jizzle James returned recently, adding depth to the rotation.

Clemson: Zac Foster is out for the season with a torn ACL.

Environment

Bon Secours Wellness Arena in Greenville provides a neutral-site setting, though Clemson’s proximity offers a slight crowd edge. Cincinnati looks to break their streak of inconsistency away from home.

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Best Bets and Prediction

Projected Final Score: Clemson 82, Cincinnati 74

  • Clemson -6.0 → Best Bet. Their offensive pace and efficiency make them the sharper side.
  • Over 139.5 → Total play. Both teams’ scoring averages point toward a combined score above the line.

Clemson’s depth and shooting should dictate the game. Expect the Tigers to cover comfortably, while the total trends over due to both teams’ offensive pace.

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