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The Colorado Buffaloes head south to take on the Houston Cougars in the Big 12 opener for both programs on Friday, September 12, 2025. Deion Sanders has kept his quarterback decision under wraps, while Houston enters riding an undefeated start. Opening Odds: Houston -6.5, Colorado +6.5, Total 49.5 Colorado’s offensive spark will depend on quarterback Ryan Staub — if he gets the nod. Against Delaware, Staub threw for 157 yards and two touchdowns on just 10 attempts, pushing the Buffaloes’ passing game into rhythm. The Buffaloes must protect the football and avoid stalling drives. Their defense has held opponents in check but faces a much stronger rushing attack in Houston. Colorado’s ability to stretch the field with explosive plays is

The Arizona Wildcats will host the Kansas State Wildcats in a primetime nonconference battle on Friday, September 12, 2025, in Tucson, Ariz. While both schools now share the Big 12, this matchup was scheduled prior to Arizona’s conference move and will not count in league standings. Opening Odds: Arizona -7, Kansas State +7, Total 55.5 Arizona’s offense has been explosive behind quarterback Noah Fifita, who threw for 373 yards and five touchdowns in a 48-3 rout of Weber State. Fifita started 14-for-14, showcasing precision and rhythm in the passing attack. The defense has been just as sharp, holding opponents without a touchdown through the first two weeks. If the Wildcats continue to generate pressure and force Kansas State into passing

Two undefeated rivals collide in Winston-Salem as the NC State Wolfpack visit the Wake Forest Demon Deacons in their ACC opener on Thursday night. Both squads are 2-0, but NC State arrives battle-tested while Wake Forest has cruised at home. Opening Odds: NC State -3, Wake Forest +3, Total 52.5 The Wolfpack have already survived two nail-biters, defeating East Carolina and Virginia with clutch late-game execution. That experience under pressure is invaluable. Quarterback CJ Bailey has been the difference-maker, posting 518 passing yards with two TDs while adding 65 rushing yards and three more scores on the ground. His dual-threat ability forces defenses to stay honest. If NC State’s offense can keep drives alive and Bailey continues making plays in

The Green Bay Packers look to ride the momentum of Micah Parsons’ Lambeau debut when they host the Washington Commanders on Thursday Night Football. Both teams opened 1-0 with convincing defensive wins, but only one can keep that unbeaten streak alive in Week 2. Opening Odds: Packers -3, Commanders +3, Total 44.5 Green Bay’s defense dominated Detroit in Week 1, holding the Lions to 246 total yards and keeping them out of the end zone until the final minute. Parsons added a sack, while the unit piled up nine tackles for loss and four sacks overall. Quarterback Jordan Love was efficient, completing 16 of 22 passes for 188 yards and two TDs. Josh Jacobs chipped in 66 rushing yards, giving