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Murray State heads to Des Moines on Wednesday, January 21, 2026, for a 7:00 PM ET tip at The Knapp Center against Drake in Missouri Valley action. This is a classic MVC spot where the better record is on the road, but the building can still matter. Murray State has been one of the hottest teams in the league, while Drake is trying to stabilize a season that’s been uneven, especially at home. The market is leaning hard toward Murray State, laying 5.5 with a strong moneyline price. The total is 157.5, which is aggressive for a conference game unless Murray State pulls Drake into a faster scoring script. If Drake can control tempo, it gets harder for the favorite

Indiana State heads to Peoria on Wednesday, January 21, 2026, for a 7:00 PM ET Missouri Valley matchup with Bradley at Carver Arena on ESPN+. The market is giving Bradley real respect at home, and it’s earned. The Braves are 11-2 in this building and laying 8.5 against an Indiana State team that’s been shaky away from Terre Haute. Both offenses can score, and the total is set high at 153.5. That’s the key tension here. Bradley is favored by multiple possessions, but a high total often keeps the backdoor open because scoring runs happen fast, especially if the underdog can make shots late. These are the current betting lines, and bettors should keep tracking the latest college basketball odds

Notre Dame heads to Chapel Hill on Wednesday, January 21, 2026, for an ACC matchup with No. 22 North Carolina at the Dean E. Smith Center. Tip is set for 7:00 PM ET on ESPN2. The market is pricing this as a clear home-floor spot, with UNC laying 11.5 and Notre Dame catching a big number. Notre Dame is 10-8 and just 2-4 on the road, which explains the underdog tag. North Carolina is 14-4 and 12-1 at home, and that’s the biggest driver of this spread. The total is 148.5, so bettors are being asked whether Notre Dame can slow it down enough to keep this inside the number, or whether UNC’s efficiency at home turns it into a

Pittsburgh heads to Chestnut Hill on Wednesday, January 21, 2026, for a 7:00 PM ET tip at the Silvio Conte Forum on ACCN. The market has Pitt as a short road favorite, and that’s always a bet on “who steadies first” more than raw talent. Both teams are 8-10, but they’ve arrived there in different ways. Pittsburgh has looked volatile, including that 100-59 loss at Louisville, while Boston College has been far more dependable at home with a 7-5 record. With the spread at Pitt -1.5 and a low total of 136.5, you’re looking at a game that’s expected to be a half-court battle where a few empty possessions swing everything. These are the current betting lines, and bettors should