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The Texas Longhorns bring one of the top defenses in college football into The Swamp as they meet the Florida Gators in a Week 6 SEC clash. Texas has allowed only 31 points across four games and is ranked inside the top five nationally in total defense. Florida, meanwhile, has stumbled through three straight losses, including a 26-7 setback to Miami, where the offense failed to convert a single third down. This key matchup is featured in the college football week 6 odds and predictions. Texas opened around a touchdown favorite and currently sits at -6.5 with a moneyline of -248. Florida is a +203 underdog at home, while the total is set at 42.5. Bettors are split on the

A year after pulling off one of the biggest upsets in program history, Vanderbilt returns to Tuscaloosa with belief that it can shock Alabama again. Quarterback Diego Pavia led the Commodores past the then-No. 1 Crimson Tide in 2024, and now both teams enter ranked and eyeing SEC supremacy. Week 6 of the 2025 college football season delivers a marquee SEC matchup as No. 16 Vanderbilt (5-0, 1-0 SEC) visits No. 10 Alabama (3-1, 1-0 SEC) on Saturday, October 4 at 3:30 PM ET. The game will be televised nationally on CBS. Oddsmakers opened Alabama as a −9.5 favorite, and early money has pushed the line to −10.0. The total opened at 58.0 and has held steady, with bettors expecting

Top-ranked Ohio State welcomes Minnesota to Columbus for a Big Ten primetime battle. The Golden Gophers are trying to ride the momentum of last week’s dramatic win over Rutgers, but the challenge escalates against a Buckeyes defense that has been nearly untouchable through four games. Week 6 of the 2025 college football season features Minnesota visiting No. 1 Ohio State on Saturday, October 4 at 7:30 PM ET on NBC. The Buckeyes opened as −23.5 favorites, and the line has crept to −24.0. The total has held steady at 44.5, with bettors divided on whether Minnesota can score enough to push the game over. Current odds: Track real-time adjustments on the NCAAF scores and odds board. Minnesota (3-1, 1-0 Big

The Oklahoma Sooners are turning to Michael Hawkins Jr. at quarterback as they host the Kent State Golden Flashes in Norman on Saturday. With John Mateer sidelined by a broken hand, Hawkins steps into a favorable spot, surrounded by a deep group of receivers and a defense ranked among the nation’s best. The Sooners are heavy favorites, and bettors can find this blowout watch highlighted in the college football week 6 odds and predictions. Oddsmakers opened Oklahoma as a massive -44 favorite, and the line has pushed up slightly to -45.5. The Sooners are priced with no moneyline, while Kent State remains a +45.5 dog. The total sits at 53.5, and with Oklahoma’s explosive offense, sharp bettors are looking to