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The Yankees head into Seattle on Monday night at 3-0 after sweeping the Giants and allowing almost nothing on the mound in that opening series. New York has looked sharp early, especially from a pitching standpoint, and now gets its first real road test at T-Mobile Park against a Mariners club that split its first four games and just handled Cleveland 8-0 on Sunday. First pitch is set for 9:40 p.m. ET, with Ryan Weathers making his Yankees debut against Luis Castillo. This is a pretty interesting early-season matchup because both teams can make a case through pitching. The Yankees have opened the year with dominant run prevention, while Seattle has already shown enough swing-and-miss stuff to make life difficult

San Francisco heads into Petco Park on Monday night still searching for its first win after an ugly opening sweep against the Yankees. The Giants scored only one run in three games and now open an NL West series against a Padres club that went 1-2 against Detroit but at least showed some life on the mound. First pitch is set for 6:40 p.m. local time in San Diego, with Landen Roupp lined up against Walker Buehler in his Padres debut. This matchup matters early because both teams already feel some pressure, just in different ways. The Giants need offense, badly, while the Padres are trying to prove their rotation can hold together behind Dylan Cease’s departure and injuries elsewhere

Cleveland heads to Los Angeles on Monday night for the opener of a three-game set at Dodger Stadium, with first pitch scheduled for 10:10 p.m. ET. The Guardians come in at 2-2 after getting shut out 8-0 by Seattle on Sunday, while the Dodgers are 3-0 after sweeping Arizona to open the season. Probable starters are left-hander Parker Messick for Cleveland and right-hander Roki Sasaki for Los Angeles, and the early market has the Dodgers sitting as a clear home favorite. This is one of those early-season spots where the records matter a little, but the context matters more. Cleveland is trying to reset after a flat offensive showing in Seattle. Los Angeles has not only won all three games,

Detroit opens Arizona’s home schedule Monday night at Chase Field, with first pitch set for 10:10 p.m. ET in Phoenix. The Tigers come in 2-1 after taking two of three in San Diego, while the Diamondbacks limp home at 0-3 after getting swept by the Dodgers and letting late leads slip away twice. Detroit sits atop the AL Central for now, Arizona is buried early in the NL West, and that makes this spot feel a little bigger than a typical game-four in March. The pitching matchup is Justin Verlander against Mike Soroka, which is interesting for a few reasons. Verlander is back with Detroit and making his first regular-season start of 2026 after a rough spring, while Soroka is