Arizona Diamondbacks vs Cincinnati Reds Picks and Predictions August 22nd 2025

Arizona Diamondbacks vs Cincinnati Reds August 22nd 2025

The Cincinnati Reds will visit the Arizona Diamondbacks at Chase Field in Phoenix, AZ. The game is set for Friday, August 22, 2025, at 9:40 PM. The Reds have a record of 67-61 and are third in the NL Central. They recently lost their last game but have won six of their last ten.

The Arizona Diamondbacks hold a record of 62-66, also ranking third in their division, the NL West. They come into this game with a two-game winning streak and a 5-5 record over their last ten games. The starting pitchers are Zack Littell for the Reds and Ryne Nelson for the Diamondbacks. The game will be shown on FDSOH, and the weather is expected to be very hot with broken clouds.

Reds vs Diamondbacks Key Information

• Sport: Baseball
• Teams: Cincinnati Reds vs. Arizona Diamondbacks
• Venue: Chase Field in Phoenix, AZ
• Date: Friday, August 22, 2025
• Betting Odds: Reds Moneyline +116, Diamondbacks Moneyline -136, Reds Runline +1.5 (-180), Diamondbacks Runline -1.5 (+151), Total Over 9.0 (-112), Total Under 9.0 (-108)

The Reds Can Win If…

The Cincinnati Reds recently played against the Los Angeles Angels and lost 2-1. Nick Martinez was strong on the mound, pitching six innings and allowing only one run. Ke’Bryan Hayes and Noelvi Marte led the offense with multiple hits, keeping the game close.

The Reds have shown they can win with their balanced lineup. Elly De La Cruz stands out with a .273 batting average and 19 home runs. The team ranks 10th in batting average and on-base percentage, which helps them stay competitive in games.

Zack Littell will start for the Reds with a solid ERA of 3.52. The Reds’ pitching staff ranks 5th in batting average against, limiting opponents’ hits. With their strong pitching and capable lineup, the Reds have a good chance to win this game.

The Diamondbacks Can Win If…

The Arizona Diamondbacks won their most recent game against the Cleveland Guardians with a score of 3-2. Brandon Pfaadt pitched seven strong innings, allowing only two earned runs. Lourdes Gurriel Jr. had a key performance, going 2-for-4 with a home run and two RBIs.

Arizona’s offense has been consistent, with a team batting average of .251, ranking 7th in the league. Their slugging percentage of .439 is 3rd best, showing their power at the plate. With 178 home runs this season, they are ranked 5th, which adds to their ability to score runs quickly.

Ryne Nelson will take the mound for the Diamondbacks, bringing a solid ERA of 3.58. His WHIP of 1.07 indicates good control over the game. With key hitters like Ketel Marte and Corbin Carroll in the lineup, Arizona has the potential to secure another win at home.

The Lean

The Diamondbacks are favored with a moneyline of -136. The Reds have a moneyline of +116. The Diamondbacks have a better batting average and on-base percentage, ranking 7th and 5th, respectively. The model projects the Diamondbacks to win with a score of 5-4. Based on these factors, the pick is for the Diamondbacks to win straight up.

The total for the game is set at 9.0 runs. The Diamondbacks have a strong slugging percentage, ranking 3rd, and the Reds’ pitching ERA is ranked 25th. The model projects a combined score of 9 runs. Given these stats, the recommendation is to take the over on the total runs.

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Reds Look to Stay Hot in Wild-Card Chase as They Visit Diamondbacks

PHOENIX — With the National League wild-card race tightening, the Cincinnati Reds are playing some of their best baseball at the right time. As they open a critical three-game series against the Arizona Diamondbacks on Friday, Cincinnati will aim to continue its climb up the standings — and possibly overtake the New York Mets.

The Reds have made up five games in the standings since Aug. 11, thanks to consistent play and a league-best distinction: they remain the only MLB team not to be swept this season.

Before betting on this weekend’s action, check the latest MLB scores and odds to see where the smart money is trending.

Friday’s Pitching Matchup: Littell vs. Nelson

Right-hander Zack Littell continues to prove his value after being acquired at the trade deadline. He’s 1-0 with a 3.06 ERA in three starts for the Reds and gave up just one run over six innings in his last outing against Milwaukee. A late error cost him a win, but Littell remains a key rotation piece for a Cincinnati team hungry for October baseball.

“I’m not worried about anybody but our team,” said catcher Jose Trevino. “Take care of what we have to take care of first.”

Littell has one prior start at Chase Field, allowing three runs over six innings with the Tampa Bay Rays earlier this season.

For the D-backs, Ryne Nelson will try to redeem himself after allowing seven runs in a June 7 start against Cincinnati. Nelson leans heavily on his 95-mph fastball, but manager Torey Lovullo says the righty has improved his off-speed mix to better challenge hitters.

“He’s really adjusting,” Lovullo said. “When he changes speeds and works side-to-side, he’s very tough to hit.”

For deeper analysis, don’t miss the expert breakdowns and betting tips in the MLB Expert Betting Guide.

NL Wild-Card Standings Snapshot

With both the Arizona Diamondbacks and Cincinnati Reds locked in a tight playoff hunt, this series could prove decisive.

Key Trends and Series Outlook

• Cincinnati has not been swept all season and is 9-3 in its past 12 games.
• Arizona is looking to bounce back after a late collapse against Colorado last weekend.
• Both teams are battling inconsistencies on defense and in their bullpens, making run support critical.

Explore full betting angles, projections, and matchup data on our MLB Picks page — updated daily with predictions from top analysts.