Arizona Diamondbacks vs Cleveland Guardians Picks and Predictions August 19th 2025

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Eduardo Rodriguez Tries to Stay Perfect vs. Cleveland

The Cleveland Guardians and Arizona Diamondbacks continue their three-game series Tuesday night at Chase Field. Cleveland took the opener 3-1, but Arizona turns to Eduardo Rodriguez, who has never lost to the Guardians in his career.

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Match Information

  • Sport: Baseball (MLB)
  • Teams: Cleveland Guardians vs. Arizona Diamondbacks
  • Venue: Chase Field, Phoenix, AZ
  • Date: Tuesday, August 19, 2025
  • Start Time: 9:40 PM ET
  • Broadcast: RSNs

Betting Odds

  • Guardians Moneyline: -103
  • Diamondbacks Moneyline: -114
  • Runline: Guardians +1.5 (-200), Diamondbacks -1.5 (+164)
  • Total: 9.0 O/U (-110/-110)

The Guardians Can Win If…

They get enough from Tanner Bibee (9-9, 4.54 ERA), who has been inconsistent but still finds ways to win. Despite allowing at least four runs in seven of his last eight starts, Cleveland’s offense has scored big behind him, giving him five wins in that stretch.

The Guardians’ attack is led by José Ramírez (.291 avg, 25 HR), who has had past success against Rodriguez (5-for-9 with a homer). Steven Kwan has also hit Rodriguez well (4-for-9). Cleveland ranks 9th in MLB in stolen bases, meaning their ability to manufacture runs could be critical against Arizona’s power-heavy lineup.

The Diamondbacks Can Win If…

Eduardo Rodriguez (5-7, 5.40 ERA) continues his dominance of Cleveland. The veteran lefty is 7-0 with a 2.51 ERA in nine career starts vs. the Guardians, including a win last August in his first game back from injury. He’s also coming off his best outing of the season — 7 innings of one-run ball against Colorado.

Offensively, Arizona has the firepower to break games open. They rank 2nd in slugging (.440) and 4th in home runs (176). Corbin Carroll and Lourdes Gurriel Jr. homered Monday, and Ketel Marte remains a steady force in the lineup. If Rodriguez keeps Cleveland in check, Arizona’s power bats can do the rest.

Key Stats Comparison

CategoryCleveland GuardiansArizona Diamondbacks
Record63-60 (2nd AL Central)60-65 (4th NL West)
Last 10 Games5-54-6
Runs Per Game4.4 (14th)4.6 (9th)
Team ERA4.07 (12th)4.58 (22nd)
Home Runs129 (17th)176 (4th)

The Lean

This matchup is about whether Bibee’s luck can continue or if Rodriguez’s 7-0 career dominance of Cleveland holds up. Arizona’s bats are more explosive, and Rodriguez is fresh off a sharp outing.

Model Projection: Diamondbacks 5, Guardians 4

  • Pick: Diamondbacks Moneyline (-114)
  • Runline Lean: Guardians +1.5 (-200) (if you prefer safety)
  • Total Lean: Over 9 (-110)

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