Arizona Diamondbacks vs Los Angeles Dodgers Picks and Predictions September 23rd 2025

The Los Angeles Dodgers will play against the Arizona Diamondbacks at Chase Field. The game is set for Tuesday, September 23, 2025, at 9:40 PM. The Dodgers, with a record of 88-68, are first in their division. They will look to bounce back after a recent loss.

The Diamondbacks, holding a 79-77 record, are third in their division. They are coming off two wins and have a strong home record. Shohei Ohtani will pitch for the Dodgers, while Brandon Pfaadt takes the mound for the Diamondbacks. The game will be shown on SN LA, and the weather is expected to be clear. The retractable roof at Chase Field should minimize any wind effects.

Dodgers vs Diamondbacks Key Information

• Sport: Baseball
• Teams: Los Angeles Dodgers vs. Arizona Diamondbacks
• Venue: Chase Field in Phoenix, AZ
• Date: Tuesday, September 23, 2025
• Betting Odds: Dodgers Moneyline -161, Diamondbacks Moneyline +136

The Dodgers Can Win If…

The Los Angeles Dodgers are coming off a narrow 3-1 loss to the San Francisco Giants. Emmet Sheehan was outstanding, throwing seven innings and allowing just one hit while striking out ten. The Dodgers’ offense had seven hits, with Alex Call and Michael Conforto contributing key hits.

The Dodgers have been strong offensively this season. They rank second in slugging percentage at .440 and have hit 232 home runs, also second in the league. With Shohei Ohtani leading the charge with 53 home runs, the Dodgers have the power to put up runs quickly.

Shohei Ohtani will start the next game for the Dodgers. He holds a solid ERA of 3.29 and a WHIP of 1.07. His ability to dominate on the mound and at the plate makes him a dual threat that could lead the Dodgers to a win against the Diamondbacks.

The Diamondbacks Can Win If…

The Arizona Diamondbacks recently dominated the Philadelphia Phillies with a 9-2 victory. Eduardo Rodriguez pitched six scoreless innings, allowing only six hits. Corbin Carroll led the offense with a home run and four RBIs, while Jorge Barrosa added three hits and a home run.

The Diamondbacks have a strong slugging percentage, ranking 3rd in the league. They also rank 5th in doubles, which shows their ability to hit for extra bases. Their lineup features power hitters like Corbin Carroll, who has 31 home runs this season.

Brandon Pfaadt will start for the Diamondbacks with a 13-8 record. Despite his 5.02 ERA, he has shown the ability to win games. With solid run support, he can secure another victory against the Dodgers.

Latest Betting Trends

• Los Angeles has clinched a playoff berth and owns a 12-1 record in division titles over the past 13 seasons.
• The Dodgers are 5-2 in their last seven games against Arizona.
• Shohei Ohtani has not pitched beyond five innings this season but is coming off a five-inning no-hit performance against Philadelphia.
• Arizona is 28-19 since the trade deadline, tied for the fifth-best record in MLB during that span.
• Corbin Carroll is the first player in Diamondbacks history to record a 30-homer, 30-steal season, also leading the majors with 17 triples.
• Brandon Pfaadt has allowed two earned runs or fewer in four of his last six starts, including nine shutout innings against San Francisco in his previous outing.

The Lean

The Dodgers are favored with a moneyline of -161. They have a strong hitting lineup with a .254 batting average and rank second in slugging percentage. The Diamondbacks have a higher ERA at 4.43, which is 23rd in the league. Our model projects the Dodgers to win with a score of 6-4. Based on these factors, picking the Dodgers on the moneyline is recommended.

The total for the game is set at 9.0. The Dodgers and Diamondbacks both have powerful offenses, ranking in the top seven for home runs. The Dodgers’ pitching staff has an ERA of 4.02, while the Diamondbacks’ is 4.43. Our model projects a total score of 10 runs. Therefore, the recommendation is to take the over at 9.0.

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Dodgers Focus on Securing the NL West

The Los Angeles Dodgers enter their three-game series with the Arizona Diamondbacks already holding a postseason spot. At 88-68, Los Angeles has its magic number at three to clinch the National League West, a division they have dominated by winning 12 of the past 13 titles.

While the Dodgers still have an outside chance of catching Philadelphia and Milwaukee for a top-two seed and a first-round bye, the focus remains on wrapping up the division. Manager Dave Roberts emphasized that his club is still working to finish the job before shifting focus to October. For more game previews, visit the MLB previews section

Shohei Ohtani will be on the mound Tuesday in the series opener. Since returning from elbow surgery in June, he has been carefully managed and has not pitched more than five innings in any start. However, his latest outing featured five no-hit innings against Philadelphia, showing flashes of his elite form. With 53 home runs and 85 extra-base hits this season, Ohtani is on track to secure another MVP award.

Diamondbacks Facing Slim but Realistic Odds

The Arizona Diamondbacks come into the series at 79-77, needing to leapfrog the New York Mets and Cincinnati Reds (both 80-76) to grab a wild-card spot. Fangraphs places their playoff odds at just 6.5 percent, and the Reds own a key tiebreaker advantage.

Despite the uphill battle, Arizona has momentum. Since the trade deadline, they own a 28-19 record, tied for the fifth-best mark in the majors. Corbin Carroll has been the centerpiece of this surge, becoming the first player in franchise history to post a 30-homer, 30-steal season while also leading the majors with 17 triples. That production has placed him in rare company with legends like Willie Mays and Jimmy Rollins. For betting insight, check out the MLB picks page

Arizona’s Tuesday starter Brandon Pfaadt is also riding high after delivering his best career outing: nine shutout innings of one-hit ball against San Francisco. Though he did not factor into the decision, his performance showed his growth and potential in high-pressure games.

Series Outlook: Urgency Meets Stability

The Dodgers are playing for seeding, while the Diamondbacks face must-win urgency. Ohtani versus Pfaadt in the opener offers a compelling pitching matchup, with both arms coming off their sharpest performances of the season.

Arizona’s margin for error is virtually gone, but manager Torey Lovullo insists his team’s resilience and belief have kept them alive. “When you are connected, you are capable of doing a lot of things,” he said, underscoring the Diamondbacks’ dangerous late-season form.

For detailed betting advice, check the expert betting guide for MLB. You can also review recent MLB game results to track how both teams have fared down the stretch.