Arizona Diamondbacks vs Philadelphia Phillies Picks and Predictions September 19th 2025

Arizona Diamondbacks vs Philadelphia Phillies September 19th 2025

The Philadelphia Phillies will take on the Arizona Diamondbacks at Chase Field. The Phillies hold a strong record of 91-62 and are leading the NL East. They have been performing well in their last 10 games with an 8-2 record. The Diamondbacks, with a record of 77-76, are in third place in the NL West. They have been more up and down in their last 10 games, going 5-5.

Philadelphia will have Taijuan Walker on the mound, who has a 4.17 ERA and a 5-8 record. Arizona will counter with Ryne Nelson, who has a 3.34 ERA and a 7-3 record. The game is set to start at 9:40 PM under clear skies, though the retractable roof at Chase Field may limit the weather’s impact. Fans can catch the game on ARID.

Phillies vs Diamondbacks Key Information

• Sport: Baseball
• Teams: Philadelphia Phillies vs. Arizona Diamondbacks
• Venue: Chase Field in Phoenix, AZ
• Date: Friday, September 19, 2025
• Betting Odds: Phillies Moneyline +105, Diamondbacks Moneyline -124, Phillies Runline +1.5 (-194), Diamondbacks Runline -1.5 (+162), Total Over 9.5 (-102), Total Under 9.5 (-120)

The Phillies Can Win If…

The Philadelphia Phillies are ready to bounce back after a tough 5-0 loss to the Los Angeles Dodgers. In that game, Jesús Luzardo pitched seven innings, giving up four runs on six hits. Despite the loss, the Phillies have shown they can perform well with wins in the two previous games against the Dodgers, scoring 9-6 and 6-5.

The Phillies have a strong lineup that ranks third in batting average at .259 and fourth in on-base percentage at .329. Kyle Schwarber leads the team with 53 home runs and 128 RBIs, making him a key player to watch. The team’s ability to hit home runs, ranking seventh with 197, gives them a strong chance to score big.

On the mound, Taijuan Walker will start for the Phillies. He has a 4.17 ERA and aims to improve his record. The Phillies’ pitching staff ranks first in quality starts with 81, showing they can keep games competitive.

The Diamondbacks Can Win If…

The Arizona Diamondbacks recently lost to the San Francisco Giants 5-1. Despite the loss, Brandon Pfaadt had an impressive performance, pitching a complete game with just one hit allowed and seven strikeouts. Corbin Carroll also contributed with a triple and an RBI.

The Diamondbacks have been strong offensively this season, ranking 4th in slugging percentage at .434 and 6th in home runs with 205. Their ability to hit for power gives them a chance to score runs quickly. Geraldo Perdomo and Ketel Marte are key players, both having solid seasons with high batting averages and RBI counts.

Ryne Nelson will start on the mound for the Diamondbacks. He has a solid ERA of 3.34 and a WHIP of 1.06, showing his ability to control the game. With Nelson’s strong pitching and the team’s power hitters, the Diamondbacks have a good chance to win against the Phillies.

The Lean

The Diamondbacks are favored with a moneyline of -124, while the Phillies are at +105. Given the Diamondbacks’ better pitching stats, with a lower earned run average and more quality starts, they have the edge. My model projects a score of Diamondbacks 5, Phillies 4, making the Diamondbacks a solid pick.

The total for the game is set at 9.5 runs, with the over at -102 and the under at -120. Both teams have strong offensive stats, ranking high in home runs and slugging percentage. My model projects a total of 9 runs, so the under 9.5 is the recommended pick.

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D-backs Push Rotation for Stretch Run

The Arizona Diamondbacks enter a crucial three-game home series against the Philadelphia Phillies two games behind the New York Mets in the National League wild-card race. Arizona has shifted to a four-man rotation for the final nine regular-season games, with Ryne Nelson set to start the opener. Nelson has been consistent down the stretch, posting a 2.40 ERA over his last five starts, all quality outings.

Arizona manager Torey Lovullo emphasized the importance of relying on his top four arms — Nelson, Zac Gallen, Eduardo Rodriguez, and Brandon Pfaadt — as the team prepares to face playoff-bound competition in Philadelphia, the Dodgers, and the Padres. Fans and bettors looking for updated projections can find the latest MLB previews to track how this rotation plan may impact Arizona’s push.

Phillies Rest Stars, Set Playoff Alignment

The Phillies, already NL East champions, enter the series at 91-62 and riding the league’s best record since the trade deadline at 30-15. Instead of pushing their ace Cristopher Sanchez, Philadelphia will hold him until Tuesday to align him for the postseason opener. Taijuan Walker will start Friday’s game, with Walker Buehler expected to piggyback for multiple innings.

Philadelphia has managed its rotation carefully while still producing results. Even without Zack Wheeler and shortstop Trea Turner, who has been out with a hamstring strain since Sept. 7, the Phillies continue to dominate. Turner is making progress and could return before the regular season ends.

Those exploring wagering options on this matchup can review detailed MLB picks to weigh Philadelphia’s rotation approach.

Player Impact and Matchups

Kyle Schwarber has been the driving force for Philadelphia, leading the NL with 53 homers and topping MLB with 128 RBIs while appearing in all 153 games. Bryce Harper has also found success against Nelson, going 4-for-9 with a home run in prior meetings.

For Arizona, the challenge will be capitalizing on their own pitching strengths while generating timely offense. Brandon Pfaadt recently threw nine scoreless innings against San Francisco, only to watch the bullpen and bats fall short in an 11-inning loss.

Those interested in sharper insights can find breakdowns through the expert MLB betting guide which outlines matchup trends and player performance indicators.

Momentum on Both Sides

Both teams arrive in strong form. The Phillies have won six straight series, including taking two of three from the Dodgers earlier this week. Meanwhile, the Diamondbacks are 26-18 since the trade deadline, the fifth-best record in the majors, and have won seven of their last nine series.

As Lovullo noted, Arizona cannot afford to be overpowered by Philadelphia’s depth and must focus on executing their style of play. Bettors can track outcomes and updates via the MLB game results page as this series unfolds.

Latest Betting Trends

• The Phillies are 30-15 since the trade deadline, the best mark in baseball during that span.
• Philadelphia has won six consecutive series and nine of its last 11.
• Kyle Schwarber has homered in four of his last seven games, adding to his league-leading totals.
• Arizona is 26-18 since the deadline and has claimed seven of its last nine series.
• Ryne Nelson has posted five straight quality starts, lowering his ERA to 3.34 on the season.
• The Phillies are 11-3 in games decided by two runs or fewer since September 1.

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