NFL Previews 
MLB Previews 
NBA Previews 
NHL Previews 
Soccer Previews 
Prediction 
Odds 
Last Recap 
Game Picks 
Top Handicapper 
Arizona Diamondbacks vs San Francisco Giants September 15th 2025
The San Francisco Giants and Arizona Diamondbacks are set to meet at Chase Field. The Giants have a record of 75-74 and are third in the NL West. They have been struggling recently with a two-game losing streak. Their last ten games show a balanced 5-5 record.
Unlock 3,000 Picks for Only $9
First Month Special!
The Diamondbacks are close behind with a 75-75 record, sitting fourth in the division. They are on a two-game winning streak and have a 6-4 record in their last ten games. The game will start at 9:40 PM under clear skies, but the retractable roof may be in use due to the hot weather.
Giants vs Diamondbacks Key Information
- Sport: Baseball
- Teams: San Francisco Giants vs. Arizona Diamondbacks
- Venue: Chase Field in Phoenix, AZ
- Date: Monday, September 15, 2025
- Betting Odds: Giants Moneyline +121, Diamondbacks Moneyline -144, Giants Runline +1.5 (-166), Diamondbacks Runline -1.5 (+138), Total Over 9.5 (+100), Total Under 9.5 (-122)
The Giants Can Win If…
The San Francisco Giants are aiming to rebound after a 10–2 loss to the Dodgers, but recent signs of life include a 5–1 win over Los Angeles where Justin Verlander shined. Even in defeat, Wilmer Flores went 2-for-4 with an RBI, showing some fight at the plate.
San Francisco ranks 8th in walks with 506 and leads MLB in fewest home runs allowed (127), which could be critical against Arizona’s power hitters. Their ability to manage contact and control the long ball gives them a fighting chance.
Rafael Devers has been a driving force with 31 home runs and 102 RBIs. If he delivers in clutch moments and the Giants can keep the ball in the park, they have the pieces to pull off a needed win.
The Diamondbacks Can Win If…
The Arizona Diamondbacks are surging after a 6–4 win over the Twins. James McCann had a breakout performance with a homer and four RBIs, and Alek Thomas added two hits. Arizona is showing the kind of lineup depth that contending teams need.
Offensively, they rank 3rd in slugging and 6th in home runs with 203. Corbin Carroll has been a key contributor, with 30 homers fueling the offense and giving the D-backs the pop they need in high-stakes matchups.
Zac Gallen will get the start, and while his 11–14 record and 1.28 WHIP suggest inconsistency, he’s capable of delivering quality innings. If he rebounds from his last outing vs the Giants, the Diamondbacks are in a strong position at home.
The Lean
Arizona is favored at –144 on the moneyline, backed by a top-10 offense and home-field edge. The Giants’ .238 batting average ranks 14th, and with rookie Kai-Wei Teng on the mound, they’re at a disadvantage. My model projects a 5–4 win for Arizona, making them the best side pick.
The total is set at 9.5 runs. While Arizona’s 4.47 ERA (23rd) raises concerns, the Giants own a top-10 staff with a 3.86 ERA. My model projects 9 total runs, so the lean is toward the under 9.5 (-122).
For more MLB betting models and in-depth game previews, check out the full MLB picks feed updated daily with sharp analysis and line movement insights.
Game Odds Snapshot
| Market | Line/Odds |
|---|---|
| Moneyline (ARI) | –144 |
| Moneyline (SF) | +122 |
| Total Runs (O/U) | 9.5 |
| Over 9.5 | +100 |
| Under 9.5 | –122 |
Arizona’s recent offensive explosion and home run threat give them a slight edge. San Francisco’s success may depend on whether they can contain the long ball.
Pitching Comparison
| Pitcher | ERA | Record | Last Start vs Opponent |
|---|---|---|---|
| Zac Gallen (ARI) | 4.84 | 11–14 | 6.2 IP, 5 ER vs SF (Sept 10) |
| Kai-Wei Teng (SF) | 7.54 | 2–4 | 4.2 IP, 4 ER vs STL (Sept 6) |
Gallen has had success against San Francisco historically but is coming off a tough outing. Teng is a rookie still finding consistency in his sixth career start.
Wild Card Implications
This series is a pivotal one in the NL Wild Card race. The Giants trail the Mets by 1.5 games for the final spot, while the Diamondbacks are just behind them. Every win counts with just over a week left in the regular season.
James McCann’s recent offensive breakout and the consistent power from Carroll have helped Arizona win four of its last six. Gallen will need to avoid the early mistakes he made against San Francisco last week.
Injury Updates and Lineup Notes
San Francisco will be without first baseman Dominic Smith, who hit the IL with a hamstring strain. Jerar Encarnacion takes his spot on the roster. Meanwhile, Arizona’s Blaze Alexander is day-to-day after taking a pitch to the elbow on Sunday.
If the Giants can work walks and shorten Gallen’s outing, they’ll have a shot. But if Arizona’s power bats strike early, it could be a long night for San Francisco’s bullpen.
