Baltimore Orioles vs Houston Astros Picks and Predictions August 21st 2025

Baltimore Orioles vs Houston Astros August 21st 2025

The Houston Astros will take on the Baltimore Orioles at Oriole Park at Camden Yards. The game is set for Thursday, August 21, 2025, at 7:15 PM. Fans can catch the game on FOX.

The Astros have a record of 69-58 and are ranked first in the AL West. They have lost their last four games. The Orioles hold a record of 59-67 and are fifth in the AL East. They have won their last three games.

Astros vs Orioles Key Information

• Sport: Baseball
• Teams: Houston Astros vs. Baltimore Orioles
• Venue: Oriole Park at Camden Yards in Baltimore, MD
• Date: Thursday, August 21, 2025
• Betting Odds: Astros Moneyline -106, Orioles Moneyline -112, Astros Runline -1.5 (+151), Orioles Runline +1.5 (-186), Total Over 9.0 (+101), Total Under 9.0 (-123)

The Astros Can Win If…

The Houston Astros are looking to bounce back after a tough 7-2 loss to the Detroit Tigers. Mauricio Dubón stood out with a home run and two RBIs. Yainer Diaz also contributed with two hits, showing promise in the lineup.

Despite recent losses, the Astros have strong stats that can help them secure a win. Their team batting average is .253, ranking 5th in the league. They also have a solid pitching lineup, with their batting average against ranked 4th at .233.

Key players like Jeremy Peña and Christian Walker are crucial to the Astros’ success. Peña boasts a .310 average, while Walker has hit 16 home runs this season. With Jason Alexander on the mound, who has a 3-1 record, the Astros have a good chance to turn things around against the Orioles.

The Orioles Can Win If…

The Baltimore Orioles recently won against the Boston Red Sox with a score of 4-3. Tomoyuki Sugano pitched five innings, allowing no earned runs and striking out three. Key hitters like Colton Cowser and Jackson Holliday contributed with doubles, helping the team secure the win.

The Orioles have shown strong hitting stats this season. They rank 12th in home runs with 151 and 10th in doubles with 205. This power at the plate can be a game-changer against any opponent.

Brandon Young will start for the Orioles with an ERA of 5.68. Despite past struggles, he recently pitched eight innings of one-hit ball against the Astros. With support from hitters like Gunnar Henderson and Jackson Holliday, the Orioles have a solid chance to win.

The Lean

The Astros are slightly favored on the moneyline at -106. My model projects the Astros to win with a score of 5-4. The Astros have a stronger pitching staff, ranking 13th in ERA compared to the Orioles’ 26th. This gives them an edge in this game.

The total for the game is set at 9.0. My model projects a combined score of 9 runs. With both teams having solid hitting but the Astros’ pitching being stronger, I recommend taking the under at 9.0 (-123). The Orioles’ pitching struggles could limit their scoring opportunities.

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Orioles’ Dylan Beavers, Samuel Basallo Eye Home Debuts vs. Astros

The buzz is back in Baltimore. Riding a strong run of form and a surge of young talent, the Baltimore Orioles are set to open a four-game series against the Houston Astros Thursday night at Camden Yards, with plenty of excitement surrounding the home debuts of prospects Dylan Beavers and Samuel Basallo.

Both players were recently called up during the Orioles’ road trip. Beavers, an outfielder, is hitting .286 through four games with an RBI. Catcher Basallo has been even more electric, slashing .300 and driving in five runs across his first three MLB games.

“I’ve had this really good ability to put the bat on the ball ever since I was a little kid,” Basallo said. “So I think that’s something I’ve taken a lot of pride in.”

Their additions couldn’t come at a better time for the Orioles, who have won six of their last seven and sit firmly in contention for the top spot in the AL East. The only blemish during that stretch was a 12-inning loss to the Astros last Saturday — a team they now have another shot to overcome.

Meanwhile, Houston limps into Baltimore on a four-game losing streak, including a 7-2 loss to the Detroit Tigers on Wednesday. The Astros were held scoreless for 31 straight innings before finally breaking through.

“We’re still in a really good position,” said Houston manager Joe Espada. “Baseball is a long, long, long season.”

Houston leads the AL West by just 1.5 games, with Seattle breathing down their neck.

Injury Concerns Loom for Both Clubs

Baltimore is dealing with its own injury issues. Star catcher Adley Rutschman hasn’t played since Sunday due to abdominal soreness, and infielder Jordan Westburg is battling an ankle injury. Interim manager Tony Mansolino said they’re taking it day-by-day.

The Astros may also be without center fielder Taylor Trammell, who had a hard fall and was carted off the field Wednesday after hitting the outfield wall. He’s being evaluated for a concussion.

Projected Starting Pitchers

• Orioles: Brandon Young (1-6, 5.68 ERA) — coming off eight shutout innings in a dominant 7-0 win vs. Houston.
• Astros: Jason Alexander (3-1, 4.74 ERA) — tossed six innings of three-hit, two-run ball vs. Baltimore last weekend.

Young nearly threw a perfect game last Friday, holding Houston hitless until an infield single with two outs in the 8th.

Recent Team Trends

Young Talent Impact

As Baltimore continues to integrate young talent into its playoff push, the timing couldn’t be more pivotal. Both clubs are in the thick of postseason chases, but the energy in Camden Yards feels different.

For more insights on this series and beyond, check the MLB Picks and the Expert Betting Guide to stay ahead of the action.