Boston Red Sox vs Baltimore Orioles Picks and Predictions May 22nd 2025

Nor’easter Threatens to Disrupt Fenway Opener

The Baltimore Orioles are looking to build momentum after breaking an eight-game losing streak, but their series opener against the Boston Red Sox may be washed out. A strong nor’easter is forecast to hit Massachusetts, putting Thursday night’s game at risk. The storm has already postponed a Triple-A game in Worcester.

Orioles Snap Losing Streak in Extra Innings

Baltimore ended its longest losing stretch since 2021 with a gritty 8-4, 11-inning win over Milwaukee on Wednesday. Adley Rutschman delivered the knockout blow with a three-run homer in the 11th, his first since April 20.

“I was super proud of our guys today,” said Rutschman. “We stayed in it and kept pushing runs across.”

The win was also the first for interim manager Tony Mansolino, who stepped in after Brandon Hyde’s dismissal. Mansolino credited the players, saying the win was about them and the organization, not himself.

Pitching Concerns Still Linger for Baltimore

While the win was uplifting, issues persist. Closer Felix Bautista, pitching on consecutive days for the first time since Tommy John surgery, struggled with command in the ninth. He walked two and allowed the tying run before the Orioles pulled ahead in extras.

“He just didn’t have command of his fastball,” said Mansolino. “But the velocity looked good.”

Score a Homerun

Premium MLB Membership

Get Free Trial

Red Sox Offense Falters Against Mets

The Red Sox come into this series after a rough 5-1 loss to the Mets, where they struck out 16 times. Ace Garrett Crochet was pulled after 85 pitches, a move manager Alex Cora said was planned in advance to protect the lefty long-term.

“We need him healthy for the full season,” Cora explained. “It was the right decision for the player.”

Probable Starters: Povich vs. Giolito

Baltimore plans to start left-hander Cade Povich (1-3, 5.23 ERA), who has struggled in three previous outings against Boston. The Red Sox counter with Lucas Giolito (1-1, 7.08 ERA), who has had mixed results in five career starts vs. the Orioles.

Betting Insights and Expert Picks

With both teams facing questions and uncertain pitching matchups, this series opener offers intriguing angles for bettors. Get the latest expert predictions at Scores and Stats MLB Picks. Want to go further? Explore premium insights via the Buy Picks section, and track top performers on the Best Handicappers Leaderboard.

If you’re looking to sharpen your strategy, don’t miss the Expert Betting Guide for MLB, offering in-depth breakdowns, trends, and data-driven tips for smarter wagers.

Final Thoughts

The Orioles are trying to regain stability under a new manager, while the Red Sox aim to keep their roster healthy and competitive. Whether Thursday’s game goes ahead will depend on the weather—but if it does, fans can expect a compelling matchup between two teams at a crossroads.