Chicago Cubs vs Milwaukee Brewers Picks and Predictions August 20th 2025

Chicago Cubs vs Milwaukee Brewers August 20th 2025

The Milwaukee Brewers will take on the Chicago Cubs at Wrigley Field. The Brewers hold a record of 79-47, leading the NL Central division. They have lost their last two games but have won seven out of their last ten. Pat Murphy manages the Brewers, with Al LeBoeuf as the hitting coach and Chris Hook as the pitching coach.

The Cubs, with a 72-54 record, are second in the NL Central, trailing the Brewers by seven games. They have won their last two games and have a 5-5 record in their last ten. Craig Counsell manages the Cubs, with Dustin Kelly as the hitting coach and Tommy Hottovy as the pitching coach. The game is scheduled for 8:05 PM under clear skies with a mild breeze. Jacob Misiorowski will start for the Brewers, while Colin Rea will take the mound for the Cubs.

Brewers vs Cubs Key Information

• Sport: Baseball
• Teams: Milwaukee Brewers vs. Chicago Cubs
• Venue: Wrigley Field in Chicago, IL
• Date: Wednesday, August 20, 2025
• Betting Odds:
  • Brewers Moneyline: -113
  • Cubs Moneyline: -104
  • Brewers Runline: -1.5 (+161)
  • Cubs Runline: +1.5 (-195)
  • Total Over: 7.0 (-103)
  • Total Under: 7.0 (-118)

The Brewers Can Win If…

The Milwaukee Brewers aim to bounce back after a recent 4-1 loss to the Chicago Cubs. In that game, Brandon Woodruff pitched 4 1/3 innings with six strikeouts. William Contreras was a bright spot, scoring the lone run for the Brewers.

The Brewers have strong season stats that show their potential. They have the second-best batting average in the league at .258 and a solid on-base percentage of .331. Their earned run average ranks second at 3.58, showing their pitching strength.

Key players like Christian Yelich and Brice Turang can make a difference. Yelich has hit 26 home runs this season, while Turang has a batting average of .279. With Jacob Misiorowski starting on the mound, the Brewers have a good chance to secure a win.

The Cubs Can Win If…

The Chicago Cubs are coming off a 6-4 win against the Milwaukee Brewers. Owen Caissie and Willi Castro were key players, each hitting a home run and driving in three runs. Matthew Boyd pitched 5 1/3 innings, allowing four runs, but the bullpen held strong to secure the win.

The Cubs have shown strength in their hitting stats this season. They rank 5th in slugging percentage at .429 and are 6th in home runs with 172. Their ability to hit for power gives them an edge in any game.

Colin Rea will start for the Cubs with a 3.99 ERA and a 9-5 record. He has been reliable on the mound, which is important against tough opponents. With their lineup and Rea’s pitching, the Cubs have a strong chance to win.

The Lean

The Brewers are favored on the moneyline at -113, while the Cubs are at -104. The Brewers have a strong pitching staff with a 3.58 ERA, ranked 2nd, and a batting average against of .229, ranked 3rd. Our model projects the Brewers to win with a score of 4-3. Based on these factors, the recommendation is to pick the Brewers to win straight up.

The total for the game is set at 7.0, with the over at -103 and the under at -118. The Brewers and Cubs both have solid pitching, with the Brewers ranked 2nd in ERA and the Cubs ranked 11th. Our model projects a total score of 7 runs. Given the strong pitching, the recommendation is to pick the under 7.0.

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Castro Shines as Cubs Aim to Take 5-Game Set vs Brewers

After sweeping a doubleheader against their division rivals, the Chicago Cubs are looking to claim the five-game set against the Milwaukee Brewers Wednesday night at Wrigley Field. Chicago still trails by seven games in the NL Central, but Tuesday’s wins were a major boost.

For sharp pregame insight and picks, check out the expert MLB betting guide and track every angle with updated MLB picks.

Willi Castro Steps Up Big

Trade deadline pickup Willi Castro was the star of Tuesday’s double dip. He crushed his first home run as a Cub—a three-run shot in Game 1—and later threw out Brice Turang at the plate in Game 2.

“It’s been tough for me since I got here,” Castro said. “But whenever I get the opportunity, I’ll get the job done.”

Rea Returns Against Former Team

Veteran righty Colin Rea (9-5, 3.99 ERA) starts Game 4 for Chicago. He pitched for Milwaukee from 2021 to 2024 and faces his old team for the second time this season.

Rea was solid in his last outing, allowing one run over five innings vs Pittsburgh, though the Cubs dropped the game 3–2.

Misiorowski Looks to Regroup

The Brewers send Jacob Misiorowski, their 23-year-old All-Star, to the mound. He’s 4–1 with a 3.89 ERA this year but struggled in his first start off the injured list last Friday, giving up five runs in just 1 1/3 innings vs the Reds.

“He wasn’t in sync,” said Brewers manager Pat Murphy. “But it’s all part of his growth.”