Chicago Cubs vs Milwaukee Brewers Picks and Predictions October 9th 2025

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The Milwaukee Brewers are set to take on the Chicago Cubs in Game 4 of the NLDS. The game will be held at Wrigley Field in Chicago, IL. The Brewers lead the series 2–1 and aim to close it out with a win.

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The Cubs will fight to extend the series to a decisive Game 5. The weather forecast for the game is clear skies with a light breeze. Fans can catch the action on TBS at 9:08 PM on October 9, 2025.

Brewers vs Cubs Key Information

  • Sport: MLB
  • Teams: Milwaukee Brewers vs. Chicago Cubs
  • Venue: Wrigley Field in Chicago, IL
  • Date: Thursday, October 9, 2025
  • Betting Odds: Brewers Moneyline -115, Cubs Moneyline -105, Brewers Runline -1.5 (+155), Cubs Runline +1.5 (-187), Total Over 7.5 (+100), Total Under 7.5 (-120)

Milwaukee Brewers vs Chicago Cubs – NLDS Game 4 Betting Preview

The Milwaukee Brewers have a chance to advance to the National League Championship Series as they visit the Chicago Cubs for Game 4 of the NLDS. Milwaukee dropped a tight 4-3 decision in Game 3 but still leads the best-of-five series 2-1.

The Cubs jumped out to another early lead thanks to Michael Busch’s first-inning homer — his third of the postseason — while the Brewers’ late rally came up short. Now, the matchup turns to a rematch between Freddy Peralta and Matthew Boyd, both of whom started Game 1.

Peralta tossed 5 2/3 strong innings in that opener, giving up two runs in a 9-3 Brewers win. Boyd, meanwhile, was chased in the first inning after allowing six runs, two earned, and will look to bounce back under immense pressure.

Milwaukee Brewers can win if

The Brewers get another composed outing from Peralta and maintain offensive pressure early. Peralta finished the regular season with a 17-8 record and a 3.18 ERA, and he’s been dominant against Chicago, going 9-3 with a 3.21 ERA over 22 career appearances.

Offensively, Milwaukee’s lineup has been quietly effective, ranking second in batting average and on-base percentage this season. Christian Yelich remains a reliable table-setter, while William Contreras and Brice Turang provide production across multiple spots in the order.

If Milwaukee continues to capitalize on runners in scoring position and keeps the Cubs’ first-inning momentum in check, they have the experience and pitching edge to move on to the next round.

Chicago Cubs can win if

The Cubs’ early offense translates into sustained production. Chicago has scored in the first inning of every game this series, but closing out wins has been the challenge. Busch has become the focal point of the lineup with three postseason homers, and Seiya Suzuki’s power (32 HR, 103 RBI) remains critical in the middle order.

On the mound, Boyd must find command early. His 5.40 ERA this postseason reflects struggles with pitch location, but if he can attack Milwaukee’s hitters and generate weak contact, the Cubs’ bullpen can keep the game tight. Chicago ranks fifth in slugging percentage (.430) and sixth in home runs (223), giving them enough firepower to even the series.

If Boyd limits damage and the Cubs’ top four hitters produce, they can extend the series to a decisive Game 5.

Line Movement and Odds

Opening: Brewers -115 / Cubs -105
Current: Brewers -120 / Cubs +100
Run Line: Brewers -1.5 (+160) / Cubs +1.5 (-180)
Total: 7.5 runs (Over -105 / Under -115)

Oddsmakers still give Milwaukee a slight edge due to Peralta’s consistency and bullpen reliability. Track all updated prices and live totals on the MLB odds page.

Matchup Breakdown

Milwaukee has leaned on elite pitching throughout 2025, ranking second in team ERA and limiting opponents to a .231 batting average. Their bullpen has also delivered under pressure, holding a 2.61 postseason ERA entering Game 4.

Chicago’s lineup continues to flash early power, but sustaining it against Milwaukee’s rotation depth is a challenge. Busch’s breakout is a bright spot, while Nico Hoerner’s consistency (.297 average, 89 runs) adds stability.

For deeper team performance data, visit the MLB teams page, and explore postseason betting trends in the MLB Betting Guide. You can also check the National League odds blog for futures context on both clubs.

Injuries and Conditions

Milwaukee Brewers

  • No major injuries reported
  • Bullpen fully available

Chicago Cubs

  • Cody Bellinger (wrist) – day-to-day
  • Matthew Boyd (fatigue) – cleared to start

Weather at Wrigley Field should be mild, around 68°F, with slight wind blowing out to right, potentially helping left-handed hitters like Yelich and Busch.

Best Bets and Prediction

The Brewers’ superior pitching depth gives them the advantage in Game 4, though the Cubs’ hot starts make this matchup less predictable. Milwaukee’s bullpen and clutch hitting have been difference-makers throughout the series.

Prediction: Brewers 4, Cubs 3
Best Bet: Brewers moneyline (-120)
Secondary Lean: Under 7.5 runs (-115)

Compare expert predictions and player prop trends on the best handicappers leaderboard before placing your bets.

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