Chicago White Sox vs Arizona Diamondbacks Picks and Predictions June 23rd 2025

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Confident White Sox Look to Tame Diamondbacks in Series Opener

For one of the few times this season, the Chicago White Sox are coming home with a genuine sense of accomplishment and momentum. Fresh off an impressive series victory on the road against the Toronto Blue Jays, the Chicago White Sox will look to carry that good feeling into Monday night’s series opener against a tough opponent, the visiting Arizona Diamondbacks. The challenge for Chicago will be to prove their recent success is sustainable and to overcome a long history of struggles against this specific club.

A Newfound Confidence in Chicago

While the White Sox still own one of the worst records in the American League, their weekend in Toronto was a massive step in the right direction. Sunday’s come-from-behind 4-2 victory, which clinched their first series win in Toronto since 2019, was a showcase in clutch performance. The hero was Miguel Vargas, who delivered a go-ahead, two-run double with two outs in the eighth inning. For Vargas, performing in high-leverage situations has become his specialty. This season with two outs and runners in scoring position, he is batting an incredible .428 with 19 RBIs. It’s that kind of performance that can lift an entire clubhouse and instill a belief that no game is out of reach.

The D-backs’ Quiet Dominance

The Diamondbacks arrive in Chicago as a confident team themselves, having won eight of their last twelve games to climb back over the .500 mark. While they lost their series finale to the Rockies on Sunday, they possess a significant historical advantage in this matchup. Arizona has won the last five consecutive series against the White Sox dating back to 2014 and holds a dominant 17-7 all-time record in their meetings. Their offense has been led by the hot bats of Ketel Marte, who has 10 hits in his last four games, and Lourdes Gurriel Jr., who carries an 11-game hitting streak into the series. They are a veteran team that knows how to win and will not be intimidated by the White Sox’s recent success.

A Rookie’s Rebound Mission

The White Sox will hand the ball to rookie right-hander Shane Smith (3-4, 2.85 ERA), who has been one of the few consistent bright spots for the team this year. However, he is coming off the first truly bad start of his young career, a 12-2 loss to the Cardinals in which he was shelled for six runs. It was the first time in 14 career starts that Smith had allowed more than three earned runs. The rookie is also adjusting to working on extended rest, a new challenge for a young pitcher used to a strict five-day routine.

“Making sure the back half of the week still has work involved and not as much recovery,” Smith said of his new approach. “Making sure that balance is there.” How young players bounce back from their first taste of adversity is a key factor in their development, a topic often discussed in our expert betting guide.

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Can E-Rod Continue His Sox Dominance?

The Diamondbacks will counter with veteran lefty Eduardo Rodriguez (2-4, 5.93 ERA), whose season has been a story of frustration. While his overall numbers are poor, he brings an incredible track record against this specific opponent. In 10 career starts against the White Sox, Rodriguez is a perfect 4-0 with a stellar 3.36 ERA, racking up 59 strikeouts in 59 innings. The question for Monday is simple: will his season-long struggles continue, or will his career-long dominance over Chicago prevail? This fascinating duel of a struggling rookie versus a veteran with a lopsided history will be a major focus on the scores and odds board.

The Bigger Picture

This series opener pits two MLB teams with very different short-term momentums and long-term goals. The White Sox are trying to prove their weekend win was the start of a respectable stretch of baseball, not just a fluke. The Diamondbacks are looking to continue their steady play and keep pace in the crowded NL Wild Card race. To see who our experts think will win this intriguing matchup, check out our daily MLB picks.

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Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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