Chicago White Sox vs Arizona Diamondbacks June 25th 2025
The Arizona Diamondbacks will take on the Chicago White Sox at Rate Field in Chicago. This afternoon game is scheduled for Wednesday, June 25, 2025, at 2:10 PM. Fans can catch the game on CHSN, with the weather forecast showing overcast clouds and warm temperatures.
The Diamondbacks, managed by Torey Lovullo, have a season record of 41-38. They stand 7 games back in the NL West. On the other side, the White Sox, led by Will Venable, hold a record of 25-55 and are 25 games back in the AL Central. Zac Gallen will start for Arizona, while Sean Burke takes the mound for Chicago.
Diamondbacks vs White Sox Key Information
- Sport: Baseball
- Teams: Arizona Diamondbacks vs. Chicago White Sox
- Venue: Rate Field in Chicago, IL
- Date: Wednesday, June 25, 2025
- Betting Odds: Diamondbacks MoneyLine -140, White Sox MoneyLine +118
The Diamondbacks Can Win If…
The Arizona Diamondbacks are coming off a 4-1 win against the Chicago White Sox. Ryne Nelson pitched five innings, allowing only one hit and striking out seven. Ketel Marte led the offense with a home run and two hits.
The Diamondbacks have strong hitting stats this season. They rank second in slugging percentage at .449 and fourth in both batting average and home runs. These stats show their ability to score runs and put pressure on opposing pitchers.
Ketel Marte and Eugenio Suárez are key players in the lineup. Marte has a batting average of .320, while Suárez has hit 25 home runs. Their consistent performances are crucial for the team’s success in upcoming games.
The White Sox Can Win If…
The Chicago White Sox are looking to bounce back after a recent 4-1 loss against the Arizona Diamondbacks. In that game, Luis Robert Jr. hit a solo home run, showing his power at the plate. Sean Burke, the starting pitcher for the upcoming game, had a solid outing against the St. Louis Cardinals on June 19th, going 5 1/3 innings with seven strikeouts.
The White Sox have some strong hitters in their lineup, including Miguel Vargas, who leads the team with 10 home runs and 34 RBIs. Chase Meidroth has a batting average of .268 and has been consistent at the plate. The team’s ability to hit doubles, ranking 13th in the league, gives them an edge in creating scoring opportunities.
On the pitching side, Sean Burke will need to keep the Diamondbacks’ hitters in check. His ERA of 4.50 and WHIP of 1.42 suggest he can manage the game effectively. The White Sox’s bullpen has been reliable, with only 14 blown saves, ranking them 8th in the league, which could be crucial in securing a win.
The Lean
The Diamondbacks are favored with a MoneyLine of -140 against the White Sox at +118. Given the Diamondbacks’ strong hitting stats, with a batting average ranked 4th and slugging percentage ranked 2nd, they have an edge. The model projects a score of Diamondbacks 5, White Sox 3, making the Diamondbacks the pick to win straight up.
The current over/under line is set at 9.0. The Diamondbacks’ pitching has an ERA of 4.70, ranked 24th, while the White Sox have an ERA of 4.25, ranked 20th. With the model projecting a total score of 8, the recommendation is to take the under.
Banged-Up Diamondbacks Go For Sweep of White Sox
The wins keep coming for the Arizona Diamondbacks, but so do the injuries. The Arizona Diamondbacks clinched a series victory and a winning road trip with a 4-1 win on Tuesday, but they will enter Wednesday’s finale against the host Chicago White Sox with a severely depleted roster as they aim for a sweep.
The Walking Wounded
Arizona’s training room is getting crowded. The team lost infielder Ildemaro Vargas to a fractured foot after he was hit by a pitch on Tuesday. This comes just a day after third baseman Eugenio Suarez suffered a significant hand contusion, and just a week after star outfielder Corbin Carroll was placed on the injured list with a fractured wrist. It’s a brutal string of injuries for a team that has been playing its best baseball of the season. How a team’s odds are affected by a sudden injury cluster is a key topic in our expert betting guide.
Marte Leads the Charge
Despite the injuries, the Diamondbacks’ offense keeps producing, largely thanks to the red-hot Ketel Marte. Marte has homered in two straight games and is hitting a blistering .577 (15-for-26) with three home runs and nine RBIs over his past six games. His performance has carried the lineup and has been a key reason for the team winning eight of its last twelve games.

A Duel of Pitchers Seeking Form
Wednesday’s pitching matchup features two right-handers looking for a strong outing. The Diamondbacks will start their ace, Zac Gallen (5-8, 5.60 ERA). While Gallen got the win in his last start, it was an unusual performance where he allowed seven runs. He’ll be looking for a much sharper, more dominant outing, and he has a history of success against the White Sox, having thrown seven shutout innings against them in his only career meeting.
The White Sox will counter with rookie Sean Burke (3-7, 4.50 ERA), who is trying to recapture his excellent May form after struggling in June. This matchup will be a major focus on the scores and odds board.
Chicago’s Search for Positives
The White Sox have lost 11 of their last 13 games and own the most losses in the American League. The organization is focused on finding small victories and positive signs from their young players. “There are some positives that we can hang our hat on and continue to move forward,” general manager Chris Getz said. For two MLB teams at different points in their season, the goals for Wednesday are vastly different. To see if our experts think the D-backs can complete the sweep despite their injuries, check out our daily MLB picks.