Chicago White Sox vs Detroit Tigers Picks and Predictions June 5th 2025

Chicago White Sox vs Detroit Tigers June 5th 2025

The Detroit Tigers will take on the Chicago White Sox at Rate Field in Chicago. This afternoon game is set for Thursday, June 5, 2025, at 2:10 PM. Fans can watch the action on FDSDE, with the weather expected to be mild and a light breeze blowing out.

The Tigers, managed by A.J. Hinch, have a strong record of 40-22 this season. They will rely on Casey Mize, who has an ERA of 2.82, to lead the pitching. On the other side, the White Sox, led by Will Venable, have struggled with a 19-42 record. Sean Burke will be on the mound for them, carrying an ERA of 4.20 into the game.

Tigers vs White Sox Key Information

• Sport: Baseball
• Teams: Detroit Tigers vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Thursday, June 5, 2025
• Betting Odds: Tigers MoneyLine -214, White Sox MoneyLine +177

The Tigers Can Win If…

The Detroit Tigers are coming off a tough 8-1 loss against the Chicago White Sox. Despite the outcome, Riley Greene showed consistency with a 2-for-3 performance at the plate. Beau Brieske had a brief but effective outing, allowing no hits in 1 1/3 innings with two strikeouts.

The Tigers have a solid chance to win with their strong pitching stats this season. They hold a team ERA of 3.22, ranking 5th in the league. Casey Mize, with a 2.82 ERA, leads the mound for Detroit, aiming to add to his 6-1 record.

Offensively, the Tigers have power hitters like Spencer Torkelson and Riley Greene, both with 13 home runs. Their team slugging percentage is .410, ranking 8th in the league. With players like Kerry Carpenter and Dillon Dingler contributing, the Tigers have the lineup depth to secure a win.

The White Sox Can Win If…

The Chicago White Sox are coming off a strong win against the Detroit Tigers, with a score of 8-1. Shane Smith pitched well, allowing just three hits and no runs in over five innings. Michael A. Taylor was key on offense, hitting a home run and driving in four runs.

The White Sox have some stats that show their potential to win. Their pitching staff ranks 12th in home runs given up, which can help keep the Tigers’ bats quiet. They also have 19 quality starts this season, showing they can get good outings from their starters.

Miguel Vargas is a player to watch, with eight home runs and a .243 batting average. His power can change the game in a hurry. The team is also strong in stolen bases, ranking 11th, which can create scoring chances on the base paths.

The Lean

The Tigers are favored with a moneyline of -214 against the White Sox at +177. The Tigers have a strong pitching staff with a 3.22 ERA, ranking 5th in the league. My model projects the Tigers to win with a score of 5-3, making them a solid pick to win straight up.

The over/under line is set at 8.5 runs. The Tigers’ pitching is strong, and the White Sox struggle at the plate with a .221 batting average, ranking 20th. My model projects a total score of 8 runs, so the recommendation is to take the under 8.5.

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Tigers’ Casey Mize Looks to Break Through Against White Sox

The Detroit Tigers will look to clinch a series win Thursday as they wrap up their four-game road set against the struggling Chicago White Sox. With Casey Mize on the mound, Detroit has a chance to secure its sixth win in seven matchups this season against Chicago — but for Mize, there’s more on the line: his first career win against the division rival.

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Tigers Getting Creative With Colt Keith

Wednesday’s 7-6 win saw second-year infielder Colt Keith deliver the go-ahead double in the eighth, adding to his recent momentum at the plate. But Keith’s future impact may also come defensively, as manager A.J. Hinch revealed the team is experimenting with him at third base.

“We’re curious about how we can maximize this roster,” Hinch said. “You may see him there from time to time. We’ll see.”

Riley Greene continued to thrive as well, collecting three hits and driving in two runs. Despite a rocky middle stretch that allowed the White Sox to erase a four-run first-inning deficit, Detroit closed out late to improve to 5-1 against Chicago this season.

Mize Seeks Elusive First Win vs. White Sox

Right-hander Casey Mize (6-1, 2.82 ERA) takes the ball Thursday following his shortest start of the season — a 3 1/3-inning no-decision against Kansas City in which he allowed eight hits and three runs. Despite his stellar 2024 record and sub-3.00 ERA, Mize has yet to solve the White Sox. In seven career appearances, he is 0-4 with a 5.34 ERA.

Mize has allowed a home run in six of his past seven outings, something he’ll need to clean up if he hopes to finally crack the win column against Chicago.

MLB Picks and Pitching Matchups like this one often highlight breakout or turnaround performances — and this could be a key spot for bettors following MLB Predictions and Betting Tips.

Burke Trending Up for Chicago

Rookie right-hander Sean Burke (3-6, 4.20 ERA) will try to match his recent form for Chicago. After a rocky April, Burke turned it around in May, going 2.73 ERA across six appearances and delivering back-to-back quality starts.

“That was probably the best I felt in terms of how the stuff felt and the smoothness of the delivery,” Burke said after last weekend’s solid outing against Baltimore.

Burke previously shut down Detroit on September 28, 2024, tossing five scoreless innings with six strikeouts.

White Sox Continue to Spiral

Chase Meidroth had three hits on Wednesday, but the White Sox have now dropped eight of their last 10. Slugger Luis Robert Jr. has been benched for two straight games to focus on adjustments, despite being physically healthy.

“Just want to give him a couple of days here to lock in some of these adjustments,” manager Will Venable said of Robert, who still leads the American League with 21 stolen bases.

Chicago is searching for stability while Detroit continues to make subtle roster tweaks in an effort to stay in the AL Central race.

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