Chicago White Sox vs San Francisco Giants Picks and Predictions June 28th 2025

Chicago White Sox vs San Francisco Giants June 28th 2025

The San Francisco Giants will visit the Chicago White Sox at Rate Field in Chicago, IL, on Saturday, June 28, 2025. This afternoon game is set to start at 4:10 PM and will be broadcast on CHSN. The weather forecast predicts a warm day with a calm crosswind and scattered clouds.

The Giants, managed by Bob Melvin, hold a 45-37 record and are 6 games behind in the NL West. They have a balanced road record of 20-20. On the mound for the Giants will be Robbie Ray, who has an ERA of 2.83 and a WHIP of 1.16. The White Sox, led by Will Venable, have a 26-56 record and are 24 games behind in the AL Central. Adrian Houser, with an ERA of 2.27 and a WHIP of 1.26, will start for the White Sox.

Giants vs White Sox Key Information

• Sport: Baseball
• Teams: San Francisco Giants vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Saturday, June 28, 2025
• Betting Odds: Giants MoneyLine -170, White Sox MoneyLine +142

The Giants Can Win If…

The San Francisco Giants recently won against the Chicago White Sox, 3-1. Landen Roupp pitched well, allowing only one unearned run over 5 1/3 innings. Patrick Bailey contributed with a triple and two RBIs, helping the team secure the win.

The Giants’ pitching has been strong this season, with a team ERA of 3.41, ranking third in the league. Robbie Ray, their starting pitcher for the next game, has an impressive ERA of 2.83. This solid pitching performance gives them a good chance to win.

Rafael Devers is a key player for the Giants, with a batting average of .270 and 17 home runs. His ability to get on base and drive in runs is crucial for their offense. The Giants also rank third in walks, showing their patience at the plate, which can be a significant advantage.

The White Sox Can Win If…

The Chicago White Sox recently played against the San Francisco Giants and lost 1-3. Aaron Civale pitched for 4 innings, allowing just 1 earned run. Despite the loss, the White Sox managed 7 hits, showing they can get on base against tough pitching.

Chicago’s offense has shown potential with games like their 7-3 win over the Arizona Diamondbacks. In that game, they collected 12 hits, including 3 home runs. Lenyn Sosa was a standout, hitting 2 home runs and driving in 4 runs, demonstrating the power in their lineup.

The White Sox’s pitching can be a key factor in their success. Adrian Houser, the starting pitcher for the next game, holds a strong ERA of 2.27. With his solid performance on the mound, the White Sox have a chance to limit the Giants’ offense and secure a win.

Old Teammates Collide Again as Giants Face White Sox in Chicago

Two former Red Sox teammates face off once again as Rafael Devers and Andrew Benintendi square off Saturday afternoon in Game 2 of the weekend series between the San Francisco Giants and Chicago White Sox at Guaranteed Rate Field.

The Giants claimed a 3-1 win in Friday’s opener—marking Chicago’s 23rd game this season scoring one run or fewer. Though both Devers and Benintendi managed hits, neither played a major role in their teams’ low-output performances.

Benintendi Navigating Rebuild in Chicago

For Benintendi, his second season with the White Sox has been a frustrating ride in what’s clearly become a rebuilding campaign. He raised his batting average to .237 with a 1-for-3 outing on Friday, but his $75 million deal—the largest in White Sox history—has yet to produce a turnaround for a franchise coming off 101- and 121-loss seasons.

“When I signed here, there were some big names,” Benintendi said. “Then they got rid of everybody. Last year was terrible for all of us. But you hope the future gets better with young talent learning and growing.”

Despite the White Sox’s struggles, Benintendi remains a respected veteran presence in a clubhouse undergoing a reset. Fans looking for player-specific betting angles and props can stay up to date through the latest MLB betting lines and match breakdowns.

Devers Looks to Heat Up as Giants Seek Consistency

Devers, who played alongside Benintendi from 2017–2020 in Boston (including their 2018 World Series run), now suits up for a Giants team in far better standing than the White Sox—but still in search of offensive rhythm.

While Devers has launched two home runs in his first 10 games with San Francisco, the Giants have gone 4-6 during that stretch and scored three or fewer runs in six of those contests. On Friday, the team left several key opportunities on the table, going just 2-for-9 with runners in scoring position.

“We had chances to really break it open and didn’t do it again,” said Giants manager Bob Melvin. “That part is frustrating.”

The offensive inconsistency comes at a critical time, as San Francisco embarks on a 10-game road trip. For bettors and DFS players, consult our full MLB expert guide for insights on current offensive trends and road splits.

Pitching Matchup: Ray vs. Houser

Saturday’s game features a compelling pitching duel between left-hander Robbie Ray for the Giants and right-hander Adrian Houser for the White Sox.

• Robbie Ray (8-2, 2.83 ERA) has been a steady force in the Giants’ rotation. In four career starts against the White Sox, he’s 1-1 with a 3.08 ERA. This will be his fifth career appearance versus Chicago.
• Adrian Houser (2-2, 2.27 ERA) has been a solid addition since joining Chicago last month. The 32-year-old owns a 1-0 record and a 3.38 ERA across three career outings (one start) against the Giants.

Benintendi will be looking for his first career hit off Robbie Ray, while Devers, who went hitless with runners in scoring position Friday, will look to break through against a White Sox bullpen that has struggled to hold leads all season.

Track all pitcher vs. batter matchups and current splits in the daily MLB picks section for more actionable betting intel.

The Lean

The Giants are favored with a MoneyLine of -170 against the White Sox at +142. The Giants have a stronger pitching staff, ranking 3rd in ERA, while the White Sox rank 21st. My model projects the Giants to win with a score of 5-3, making the Giants a solid pick for the MoneyLine.

The over/under line is set at 8.5 runs. The Giants’ pitching is strong, and the White Sox have struggled offensively, ranking 21st in batting average. My model projects a total score of 8 runs, so taking the under is the recommendation here.

Red Sox Roots Run Deep in This Matchup

Devers and Benintendi were once key figures in Boston’s 2018 World Series run, combining for 45 home runs and 183 RBIs in 2019 alone. Since then, each has taken different career paths—Benintendi through Kansas City and now Chicago; Devers still producing but now wearing orange and black in San Francisco.

While both teams are far removed from that Red Sox title, their reunion adds intrigue to an otherwise uneven cross-league battle between a rebuilding team and a postseason hopeful.

Fans tracking long-term player trends can follow individual profiles in the MLB team hub for advanced stats, injuries, and lineup history.

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