Cardinals Look to Rebound in Series vs. White Sox

Chicago White Sox vs St. Louis Cardinals June 17th 2025

The St. Louis Cardinals will take on the Chicago White Sox at Rate Field on Tuesday, June 17, 2025. The game is set to start at 7:40 PM and will be broadcast on CHSN. The weather forecast predicts a very hot day with light rain and a breeze blowing in.

The Cardinals come into this game with a 37-35 record, sitting 7 games back in the NL Central. They have struggled on the road with a 15-21 record. Meanwhile, the White Sox hold a 23-49 record and are 22 games back in the AL Central. Their home record stands at 16-18. The starting pitchers are Matthew Liberatore for the Cardinals and Shane Smith for the White Sox.

Cardinals vs White Sox Key Information

Sport: Baseball
Teams: St. Louis Cardinals vs. Chicago White Sox
Venue: Rate Field in Chicago, IL
Date: Tuesday, June 17, 2025
Betting Odds: Cardinals MoneyLine -154, White Sox MoneyLine +130

The Cardinals Can Win If…

The St. Louis Cardinals are coming off a narrow 2-3 loss to the Milwaukee Brewers. Despite the defeat, Miles Mikolas had a strong performance on the mound with 7 strikeouts over 6 innings. Iván Herrera stood out at the plate, hitting a home run and driving in a run.

The Cardinals have a solid batting average of .255, ranking third in the league. Their ability to get on base is supported by their .324 on-base percentage, placing them sixth. With hitters like Brendan Donovan and Iván Herrera, the Cardinals have the potential to score runs against the White Sox.

Matthew Liberatore will be the starting pitcher for the Cardinals. He has a 4.17 ERA and a WHIP of 1.19 this season. If Liberatore can keep the White Sox hitters in check, the Cardinals have a good chance to win this game.

The White Sox Can Win If…

The Chicago White Sox are looking to bounce back after a narrow 2-1 loss to the Texas Rangers. In that game, Miguel Vargas stood out with a solo home run, his 10th of the season. Josh Rojas also contributed with two hits, showing that the team has potential at the plate.

Despite recent losses, the White Sox have strengths that can lead to a win. Their starting pitcher, Shane Smith, has an impressive ERA of 2.37 and a WHIP of 1.17. His ability to keep runs off the board could be key in their upcoming game against the St. Louis Cardinals.

The White Sox’s batting lineup has potential to score. Miguel Vargas leads with 10 home runs, and Edgar Quero has a solid batting average of .278. With these players stepping up, the White Sox have the capability to turn their fortunes around.

The Lean

The Cardinals are favored to win with a moneyline of -154. Their batting average ranks 3rd in the league, while the White Sox rank 20th. Based on these stats, the Cardinals are projected to win 5-3.

The over/under line is set at 8.5. The Cardinals’ pitching has an ERA of 4.02, while the White Sox have an ERA of 4.13. Given the projected score of 5-3, the recommendation is to take the under.

Cardinals Look to Reset in Chicago

After trudging through a grueling 11-day stretch with a 4-8 record, the St. Louis Cardinals are hoping a much-needed off day in Chicago on Monday will provide the reset they need. The Cardinals open a three-game set Tuesday against the struggling Chicago White Sox, aiming to get back on track in the National League Central race.

St. Louis slipped three games in the standings over the past week and now trails the division-leading Chicago Cubs by seven. Still, spirits in the clubhouse remain high.

“Last month was a great month, and this month has been a tough month so far,” said third baseman Nolan Arenado. “Obviously, with no days off, that makes it even tougher, but there are no excuses because everyone has to go through it. But the attitude is the same as when we were playing well, and that’s great.”

A series sweep over the White Sox, who own the fewest wins in the American League, would give the Cardinals a winning road trip. To track how teams are trending and identify value picks, visit the MLB betting picks section.

Missed Chances in Milwaukee

The Cardinals hoped to split their four-game set with the Brewers over the weekend but came up short in the finale. Down 3-2 in the ninth, St. Louis put two runners in scoring position before Brewers closer Trevor Megill struck out Victor Scott II and Masyn Winn to end the game.

Though the team exploded for eight runs on Saturday, the offensive output has lacked consistency. The return of second baseman Brendan Donovan could be a boost. Donovan had two hits Sunday in his first game back after exiting a June 10 game with toe discomfort.

Left-hander Matthew Liberatore (3-6, 4.17 ERA) is slated to start Tuesday and will try to break a three-game losing streak. He allowed five runs over five innings in his most recent start against Toronto. For more analysis on upcoming pitcher matchups, see our MLB game previews.

White Sox Return After Rocky Road Trip

The White Sox head home after a 1-5 road trip that saw them drop games in Houston and Texas. They opened the stretch with a 4-2 win over the Astros on June 10 but quickly fell into a funk, losing three of their final four games by just one run.

Chicago is expected to have center fielder Luis Robert Jr. back in the lineup Tuesday. Robert, dealing with right thumb soreness, sat out Sunday’s game but pinch-ran in the eighth and remained in to play defense. Manager Will Venable confirmed Robert is penciled in for the opener against St. Louis.

Venable himself was ejected in the first inning of Sunday’s 2-1 loss for arguing balls and strikes, a move that pitcher Aaron Civale saw as a rallying point for the team.

“Anytime a manager goes and fights for the players, that’s an awesome sign,” Civale said. “When you’re fighting for each other, that’s what’s important.”

Rookie Duel on the Mound

Right-hander Shane Smith (3-3, 2.37 ERA) will start for the White Sox and look to build on a strong outing against the Astros, where he allowed just one run on seven hits over six innings.

The pitching duel between Smith and Liberatore sets the tone for a pivotal series where both teams are desperate to find rhythm. To enhance your wagering decisions, check out our expert MLB betting guide for data-driven insight and trends.

Betting Insight and Final Word

The Cardinals have a chance to close ground in the NL Central if they can take care of business against a last-place White Sox team. With key players returning and morale staying strong, the pieces are in place for a rebound. Meanwhile, the White Sox are seeking positives in a season filled with close losses.

For premium betting predictions, visit the buy picks page and follow the top MLB handicappers to see which experts are hot going into this matchup.

Chicago White Sox vs St. Louis Cardinals Picks and Predictions June 17th 2025