Chicago White Sox vs St. Louis Cardinals Picks and Predictions June 18th 2025

Chicago White Sox vs St. Louis Cardinals June 18th 2025

The St. Louis Cardinals take on the Chicago White Sox at Rate Field in Chicago on Wednesday, June 18, 2025. This night game starts at 7:40 PM and will be broadcast on CHSN. The weather forecast predicts heavy intensity rain with mild temperatures and a light breeze blowing in.

The Cardinals, managed by Oliver Marmol, come into this game with a season record of 38-35. They hold a road record of 16-21. Sonny Gray is set to start for the Cardinals, bringing an ERA of 3.84 and a 7-2 win-loss record. Meanwhile, the White Sox, managed by Will Venable, have struggled this season with a 23-50 record. Sean Burke will take the mound for the White Sox, with an ERA of 4.71 and a 3-7 win-loss record.

Cardinals vs White Sox Key Information

• Sport: Baseball
• Teams: St. Louis Cardinals vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Wednesday, June 18, 2025
• Betting Odds: Cardinals MoneyLine -190, White Sox MoneyLine +158

The Cardinals Can Win If…

The St. Louis Cardinals are riding high after a decisive 12-2 win against the Chicago White Sox. Matthew Liberatore pitched six solid innings, allowing only two earned runs. Alec Burleson and Victor Scott II each contributed home runs, showcasing the team’s offensive depth.

The Cardinals’ batting average ranks second in the league at .257, indicating their consistent hitting ability. Brendan Donovan leads the team with a .323 average, while Willson Contreras has driven in 45 runs. Their ability to get on base and drive in runs makes them a formidable offensive force.

Sonny Gray will take the mound for the Cardinals, bringing a 7-2 record and a 3.84 ERA. His experience and skill set give the team a strong chance to control the game. With their solid pitching and powerful lineup, the Cardinals are well-positioned to secure another victory.

The White Sox Can Win If…

The Chicago White Sox are coming off a tough game against the St. Louis Cardinals, losing 12-2. Despite the loss, Edgar Quero showed promise with two hits and one RBI. Miguel Vargas and Lenyn Sosa each contributed with a double, showing they can deliver key hits.

Looking at their season stats, the White Sox have hit 113 doubles, ranking 16th in the league. Their ability to get extra-base hits can be crucial in generating runs. With 235 walks, they also show patience at the plate, which can lead to scoring opportunities.

Sean Burke will take the mound for the White Sox. Although his record is 3-7, he has the potential to keep the team in the game. The team will rely on key hitters like Miguel Vargas and Edgar Quero to support him with runs.

The Lean

The Cardinals are favored with a MoneyLine of -190 against the White Sox at +158. With a strong batting average ranked 2nd in the league, the Cardinals have a better chance to win. My model projects a score of Cardinals 5, White Sox 3. Based on this, the recommendation is to pick the Cardinals to win straight up.

The over/under line is set at 8.5. The Cardinals’ solid hitting and the White Sox’s pitching struggles suggest a higher-scoring game. My model projects a total score of 8, which is close to the line. However, given the Cardinals’ offensive strength, the recommendation is to take the over 8.5.

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Donovan’s Hot Streak Sparks Cardinals Against Skidding White Sox

Brendan Donovan is providing a major spark at the top of the lineup for the St. Louis Cardinals, and they’ll look to him again on Wednesday night as they try to clinch a series win against the struggling Chicago White Sox.

Donovan Delivers at Leadoff

With traditional leadoff man Lars Nootbaar working through a deep slump, Donovan has stepped into the top spot and thrived. He is 6-for-8 in the last two games, including a 4-for-5 performance in Tuesday’s 12-2 rout of Chicago. Donovan currently leads all National League second basemen in hits and doubles, making him one of the most productive players among all MLB teams.

A Duel of Pitchers Seeking Redemption

Wednesday’s game features a compelling matchup of two talented pitchers who are both looking to bounce back from their worst starts of the season. The Cardinals will send out veteran ace Sonny Gray (7-2, 3.84 ERA), who had a streak of four straight quality starts snapped his last time out. However, Gray has a fantastic 3.26 career ERA against the White Sox.

Chicago will counter with rookie right-hander Sean Burke (3-7, 4.71 ERA), who also had a three-start quality streak snapped when he was rocked by the Astros last week. “That’s what it’s all about… performing in this league. You are not going to be good all the time,” said White Sox manager Pedro Grifol. “How do you make the adjustments and get back on track?”

This battle of two pitchers trying to rebound will be a key focus on the scores and odds board.

White Sox Looking to Stop the Skid

The White Sox are currently mired in a six-game losing streak and will need a strong outing from their rookie to have a chance against the Cardinals’ potent offense. How a team navigates a long losing streak is a difficult challenge, a topic often explored in our expert betting guide.

To see if our experts think the Cardinals will make it two in a row, check out our daily MLB picks.