Chicago White Sox vs St. Louis Cardinals Picks and Predictions June 19th 2025

Chicago White Sox vs St. Louis Cardinals June 19th 2025

The St. Louis Cardinals will take on the Chicago White Sox at Rate Field in Chicago, IL. The game is set for Thursday, June 19, 2025, at 5:40 PM. Fans can catch the action on CHSN. The weather forecast predicts a warm day with light rain and a breeze.

The Cardinals enter this game with a 38-35 record, standing 7 games back in the NL Central. They have a road record of 16-21. The White Sox have a 23-50 record and are 23 games back in the AL Central. Their home record stands at 16-19. Michael McGreevy will start for the Cardinals, while Mike Vasil will pitch for the White Sox.

Cardinals vs White Sox Key Information

• Sport: Baseball
• Teams: St. Louis Cardinals vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Thursday, June 19, 2025
• Betting Odds: Cardinals MoneyLine -165, White Sox MoneyLine +138

The Cardinals Can Win If…

The St. Louis Cardinals are coming off a big win against the Chicago White Sox, taking the game 12-2. Matthew Liberatore pitched six innings, allowing only two runs. Alec Burleson and Victor Scott II each hit a home run, contributing to the team’s 13 hits.

The Cardinals have a strong batting average, ranking 2nd in the league at .257. Their ability to hit doubles is notable, with 127 on the season, placing them 5th in the league. With Brendan Donovan hitting .323 and Willson Contreras driving in 45 runs, their lineup is a threat.

Michael McGreevy will start for the Cardinals, holding a 3.09 ERA and a WHIP of 0.86. His control on the mound could be key against the White Sox. With a solid mix of hitting and pitching, the Cardinals have the tools needed to win this game.

The White Sox Can Win If…

The Chicago White Sox are looking to bounce back after their recent 12-2 loss to the St. Louis Cardinals. Despite the loss, Edgar Quero had a solid performance with two hits and one RBI. Lenyn Sosa also contributed with a double and a run scored.

One reason the White Sox can win is their strong starting pitcher, Mike Vasil. Vasil has an impressive ERA of 1.99 this season, which gives the team a good chance to keep the Cardinals’ offense in check. The White Sox also rank 14th in doubles, showing they can hit for extra bases.

Miguel Vargas is another key player for the White Sox. He leads the team with 10 home runs and has a batting average of .242. With Vasil on the mound and Vargas at the plate, the White Sox have the tools to secure a win.

The Lean

The Cardinals are favored with a moneyline of -165 against the White Sox at +138. The Cardinals have a higher batting average and on-base percentage, which gives them an edge. My model projects the Cardinals to win with a score of 5-3. Based on this, the recommendation is to pick the Cardinals to win straight up.

The current over/under line is set at 9.0 runs. The model’s projected total score is 8 runs. Both teams have average pitching, but the hitting stats suggest a lower scoring game. Therefore, the recommendation is to take the under 9.0 runs.

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Rookie Starters and Rain Delay Set the Stage for Twin Bill

A rainout on Wednesday has set the stage for a Thursday doubleheader between the Chicago White Sox and St. Louis Cardinals. With three rookie pitchers expected to start across the two games, both teams are leaning into development as they navigate the midseason grind.

Chicago will turn to Sean Burke and Mike Vasil, while St. Louis will counter with veteran Erick Fedde and rookie Michael McGreevy. Each starter brings a unique storyline to a day where opportunities for young arms could shape the series.

Get more matchup insights at the MLB previews section and keep up with all the latest betting lines and predictions at Scores and Stats MLB picks.

Contreras Sparks Cardinals While White Sox Catchers Develop

The Cardinals opened the series with a dominant 12-2 win on Tuesday, powered by a four-hit effort from Brendan Donovan and four RBIs from Ivan Herrera. Yet, the highlight of the night came from Willson Contreras, who stole home for the first time in his career. The daring play came in the fifth inning and was confirmed after a replay review, narrowly beating the tag of White Sox rookie catcher Edgar Quero.

Quero also chipped in with two hits and an RBI, continuing his on-the-job development alongside fellow rookie catcher Kyle Teel. Both players are getting regular opportunities behind the plate as part of the White Sox’s long-term rebuilding strategy.

Manager Will Venable praised their preparation and drive, emphasizing how in-game reps are a critical part of their learning curve.

For insight on how young rosters can affect betting outcomes, visit the MLB expert betting guide.

Game 1 Preview: Burke vs. Fedde

Game 1 of the doubleheader will feature White Sox rookie Sean Burke against Cardinals veteran Erick Fedde. Burke enters with a 3-7 record and a 4.71 ERA. He struggled in his last outing, allowing seven runs and eight hits over 3 2/3 innings against Houston. Thursday marks his first career appearance versus St. Louis.

Fedde, who pitched for the White Sox last season, has been solid if unspectacular since joining the Cardinals. He’s 3-6 with a 3.65 ERA and has posted a 3.34 ERA over his last six starts, though he hasn’t registered a win during that stretch. His familiarity with Chicago’s hitters adds an extra layer of intrigue to the matchup.

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Game 2 Preview: Vasil vs. McGreevy

The second game will pit two rookies against each other in what could be a glimpse into the future for both clubs.

Mike Vasil, who holds a 3-2 record with a stellar 1.99 ERA, will get the ball for the White Sox. In his most recent outing, he threw four shutout innings against the Texas Rangers, allowing just two hits while working around four walks and a hit batter. Though he didn’t factor into the decision, Vasil showed resilience despite command issues.

St. Louis will counter with Michael McGreevy, who will be recalled from Triple-A Memphis. He last appeared in the majors on June 8, giving up four runs over six innings to the Dodgers. However, he bounced back with six scoreless innings in the minors and will look to carry that momentum into Thursday’s appearance.

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Final Thoughts

Thursday’s doubleheader between the White Sox and Cardinals brings an opportunity to see multiple rookies in high-leverage roles. With both teams focused on player development and lineup experimentation, bettors should approach these games with a nuanced strategy.

Whether you’re following pitching trends, scouting rookies, or looking for betting value, this doubleheader offers a compelling midweek slate. For full breakdowns, picks, and analysis across every MLB series, visit the MLB betting picks and previews hub.