Cleveland Guardians vs Baltimore Orioles Picks and Predictions July 22nd 2025

Cleveland Guardians vs Baltimore Orioles July 22nd 2025

The Baltimore Orioles will play against the Cleveland Guardians at Progressive Field on Tuesday, July 22, 2025. The game is set to start at 6:40 PM and will be broadcast on CLEG. The weather forecast predicts a warm night with a clear sky and a light breeze blowing out.

The Orioles have a record of 44-55 this season and are 14 games behind in the AL East. Interim manager Tony Mansolino leads the team, with Brandon Young starting on the mound. Young has an ERA of 7.52 and a WHIP of 1.78. The Guardians have a record of 49-50 and are 10 games back in the AL Central. Managed by Stephen Vogt, the Guardians will start Joey Cantillo, who holds a 4.17 ERA and a WHIP of 1.44.

Orioles vs Guardians Key Information

• Sport: Baseball
• Teams: Baltimore Orioles vs. Cleveland Guardians
• Venue: Progressive Field in Cleveland, OH
• Date: Tuesday, July 22, 2025
• Betting Odds: Orioles Moneyline +117, Guardians Moneyline -138, Orioles Runline +1.5 (-183), Guardians Runline -1.5 (+152), Total Over 8.5 (-110), Total Under 8.5 (-110)

The Orioles Can Win If…

The Baltimore Orioles are coming off a 5-10 loss against the Cleveland Guardians. Despite the loss, Ramón Laureano showed power with a home run and four RBIs. Jackson Holliday also contributed with two hits, highlighting the potential in their lineup.

The Orioles have shown they can hit for power, ranking 11th in the league with 115 home runs this season. Their ability to hit the long ball can change the momentum of a game quickly. With players like Jackson Holliday and Ryan O’Hearn, who have combined for 25 home runs, they have the tools to score runs in bunches.

Brandon Young will start for the Orioles, and while his ERA is high, he has the chance to turn things around. The Orioles’ bullpen has been solid in avoiding blown saves, ranking 4th in the league. If the Orioles can get an early lead, their bullpen can help secure a win.

The Guardians Can Win If…

The Cleveland Guardians are coming off a strong win against the Baltimore Orioles, taking the game 10-5. In that game, they had 14 hits with 3 home runs. José Ramírez stood out with a home run and 3 RBIs, while Kyle Manzardo and Bo Naylor also contributed with home runs.

Key stats show the Guardians have power in their lineup. They rank 18th in home runs this season with 105. Their pitching staff has been solid too, with a team ERA of 3.95, which is 17th in the league.

Joey Cantillo will start on the mound for Cleveland. He has a 4.17 ERA and has shown he can handle pressure. With the Orioles starting Brandon Young, who has struggled with a 7.52 ERA, the Guardians have a good chance to capitalize.

The Lean

The moneyline pick for this game is the Guardians at -138. The Orioles have a batting average of .239, ranking 16th, while the Guardians sit at .225, ranking 21st. However, the Guardians’ pitching has a better earned run average of 3.95, compared to the Orioles’ 5.01, which gives them an edge in this game. The model projects the Guardians to win with a score of 5-3.

For the over/under pick, the recommendation is to take the under at 8.5 runs (-110). The Orioles have given up 140 home runs, ranking 24th, and the Guardians have given up 106, ranking 8th. With both teams having some struggles in hitting, the total runs are projected to stay under 8.5. The model projects a total of 8 runs in this game.

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Jose Ramirez’s Historic Season Leads Surging Guardians Against Orioles

Just a few weeks ago, the Cleveland Guardians were in the middle of a 10-game losing streak. Now, they are one of the hottest teams in baseball, and their superstar third baseman, Jose Ramirez, is making history. The surging Cleveland Guardians will look to win their 10th game in 12 tries on Tuesday night as they continue their series against the visiting Baltimore Orioles.

A Living Legend

Jose Ramirez continues to cement his legacy as one of the best players in franchise history. With his three-run homer in Monday’s 10-5 victory, he became just the sixth player in major league history with seven career 20-homer and 20-steal seasons, joining a list that includes Barry Bonds and Eric Davis. His performance has been the catalyst for the Guardians’ incredible turnaround.

“We talk a lot about Josey and we run out of adjectives because we all love watching him play,” a beaming Cleveland manager Stephen Vogt said. “That’s one of the big reasons we love our jobs here is we get to watch him play.”

Baltimore’s Trade Deadline Questions

While the Guardians are surging, the Orioles are dealing with a struggling veteran and trade deadline questions. Tomoyuki Sugano, their big offseason signing from Japan, has pitched poorly since June and is now the subject of trade speculation. However, the 35-year-old made it clear he does not want to leave. “I really want to stay with this team,” he said. How teams handle underperforming veterans at the deadline is a key topic in our expert betting guide.

A Duel of Rookies

Tuesday’s pitching matchup features a battle of two rookies. The Guardians will start lefty Joey Cantillo (1-0, 4.17 ERA), while the Orioles will counter with right-hander Brandon Young (0-4, 7.52). Young is coming off a start where he allowed a season-high seven runs. This pitching matchup will be a key focus on the scores and odds board.

The Guardians are also getting good news on the horizon, as former Cy Young winner Shane Bieber is nearing a return from Tommy John surgery. For two MLB teams looking toward the future, the development of their young players is key. To see who our experts are backing in this matchup, check out our daily MLB picks.