Detroit Tigers vs Chicago White Sox Picks and Predictions September 6th 2025

Detroit Tigers vs Chicago White Sox September 6th 2025

The Chicago White Sox will visit the Detroit Tigers at Comerica Park on Saturday, September 6, 2025. The game is set to begin at 6:10 PM and will be broadcast on FDSDE. The White Sox have a record of 54-88 and are currently on a six-game winning streak. They are ranked fifth in the AL Central division.

The Tigers hold an 81-61 record, sitting at the top of the AL Central. They have lost their last game and have struggled in their last ten, going 3-7. The weather forecast indicates a mild day with a light breeze and broken clouds, setting the scene for an exciting evening of baseball. Tarik Skubal will start for the Tigers, while Martín Pérez will take the mound for the White Sox.

White Sox vs Tigers Key Information

• Sport: Baseball
• Teams: Chicago White Sox vs. Detroit Tigers
• Venue: Comerica Park in Detroit, MI
• Date: Saturday, September 6, 2025
• Betting Odds: White Sox Moneyline +252, Tigers Moneyline -310, White Sox Runline +1.5 (+110), Tigers Runline -1.5 (-131), Total Over 7.5 (+101), Total Under 7.5 (-123)

The White Sox Can Win If…

The Chicago White Sox come into this game with momentum after a 7-5 win over the Detroit Tigers. Colson Montgomery was a standout performer, hitting a home run and driving in four runs. Andrew Benintendi also contributed with a home run, adding to the team’s strong offensive display.

The White Sox have been impressive in their recent games, winning five in a row. Their ability to hit home runs is a key factor, with 147 homers this season, ranking them 18th in the league. The team also ranks 15th in doubles with 220, showing they can generate extra-base hits.

Martín Pérez will start on the mound for the White Sox. He has a strong ERA of 2.16 and a WHIP of 0.98, indicating his ability to keep opponents off the bases. With Pérez’s control and the team’s recent hitting form, the White Sox have a solid chance to win this game.

The Tigers Can Win If…

The Detroit Tigers recently faced the Chicago White Sox and lost 7-5. Despite the loss, Parker Meadows hit a home run, contributing 2 RBIs. Wenceel Pérez and Jahmai Jones also added to the offense with key hits.

The Tigers have a solid team batting average of .251, ranking 7th in the league. Their slugging percentage is .422, which is 9th overall. Spencer Torkelson leads the team with 28 home runs, showing their power potential at the plate.

Tarik Skubal takes the mound for the Tigers with a strong ERA of 2.18 and a WHIP of 0.87. He has a winning record of 12-4, making him a reliable option. Skubal’s ability to keep hitters off balance can lead the Tigers to victory.

The Lean

The Tigers are the pick to win the game with a moneyline of -310. The White Sox have a batting average of .236, ranked 17th, while the Tigers have a better average of .251, ranked 7th. The Tigers also have a stronger pitching staff with an ERA of 3.94, compared to the White Sox’s 4.26.

The total for the game is set at 7.5 runs. The model projects a score of Tigers 5, White Sox 3. Given the Tigers’ solid offense and the White Sox’s pitching struggles, the recommendation is to take the over at 7.5 (+101).

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Skubal’s Historic Season Continues

Detroit Tigers ace Tarik Skubal has been rewriting the franchise record books throughout the 2025 season. His latest milestone came with seven scoreless innings in a 5-0 win over the Kansas City Royals, marking his 11th start of at least six shutout innings this year. That surpassed Denny McLain’s 1969 mark for the most such outings in a single season.

Skubal enters Saturday’s matchup against the Chicago White Sox with a 12-4 record and a 2.18 ERA. If he records double-digit strikeouts, he will tie Mickey Lolich’s 1971 franchise record of 11 games with 10 or more strikeouts in a season. His command and ability to adjust to lineups that make contact instead of chasing strikeouts have made him one of the most complete pitchers in baseball.

For more coverage on matchups like this one, visit the MLB previews page

White Sox Ride Momentum into Detroit

Though the White Sox sit at the bottom of the American League Central, they have become a dangerous opponent in September. Chicago comes into this game on a six-game winning streak, highlighted by the emergence of rookie Colson Montgomery. The infielder powered Friday’s 7-5 win with a two-run homer and four RBIs, giving him 18 home runs in just 51 games.

The White Sox have staged comebacks in each of their recent wins, showing the resilience manager Will Venable has emphasized. Their competitive play could make them a tough spoiler against division-leading Detroit. Bettors following these trends can check the latest MLB picks to see where the value lies.

Pitching Matchup: Skubal vs. Pérez

Saturday’s clash features a duel between left-handers. Skubal has dominated most opponents, but he has not yet faced Chicago this season. In his career, he owns a 7-2 record with a 4.24 ERA against the White Sox.

Opposing him is veteran Martin Pérez, who has impressed since returning from an elbow injury. Pérez has allowed only three earned runs across 21 2/3 innings over his last four outings, including seven scoreless frames against Kansas City. While his 2.16 ERA looks sharp, his career numbers against Detroit tell another story, with a 2-6 record and a 4.73 ERA.

For in-depth betting strategies on how to approach pitching duels like this one, check out the expert MLB betting guide

Tigers Eye Postseason Push

At 81-61, Detroit is firmly in control of the AL Central and looks poised for a playoff run. Skubal’s dominance has been a major reason for their success, and each of his starts carries significance not only for personal milestones but also for solidifying Detroit’s postseason position.

Chicago may not be in the playoff picture, but with momentum on its side, it has the chance to make life more difficult for the Tigers. For those tracking daily outcomes, the latest MLB game results provide up-to-date insights on both teams.

Where to Find the Best Insights

Sports bettors looking to capitalize on the Tigers’ playoff push or the White Sox’s hot streak can explore more than just stats. You can secure premium analysis and expert selections through buy picks or check out the best handicappers leaderboard to see which experts are delivering consistent returns.