Houston Astros vs Minnesota Twins Picks and Predictions June 14th 2025

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The Minnesota Twins will take on the Houston Astros at Daikin Park in Houston, TX. The game is scheduled for Saturday, June 14, 2025, at 4:10 PM. This afternoon game will be broadcast on MNNT. The weather forecast predicts a very hot day with a light breeze, but the retractable roof may limit the wind’s impact.

The Twins enter with a 36-33 record, sitting 9 games back in the AL Central. On the road, they have struggled with a 16-21 record. The Astros hold a 39-30 record and have been strong at home with a 25-13 record. Starting pitchers for the game are Joe Ryan for the Twins and Hunter Brown for the Astros. Ryan has a 2.96 ERA, while Brown has a 1.82 ERA this season.

Twins vs Astros Key Information

  • Sport: Baseball
  • Teams: Minnesota Twins vs. Houston Astros
  • Venue: Daikin Park in Houston, TX
  • Date: Saturday, June 14, 2025
  • Betting Odds: Twins +106, Astros -125

The Twins Can Win If…

The Minnesota Twins are looking to bounce back from a recent loss to the Houston Astros, where they fell 10-3. Despite the loss, the Twins showed power with three home runs. Royce Lewis, Ty France, and Willi Castro each contributed a home run, demonstrating their ability to generate runs quickly.

Key stats for the Twins indicate their potential to win. They have a batting average of .244, ranking 11th in the league, and have hit 110 doubles, placing them 10th. Their pitching staff, with an ERA of 3.83, shows they can limit opposing teams’ scoring opportunities.

Joe Ryan will be on the mound for the Twins, bringing an impressive ERA of 2.96 and a WHIP of 0.93. His strong performance this season with a 7-2 record gives the Twins a solid chance to control the game. With hitters like Byron Buxton and Willi Castro in the lineup, the Twins have the tools to secure a win.

The Astros Can Win If…

The Houston Astros are coming off a strong win against the Minnesota Twins, with a final score of 10-3. Jose Altuve led the way with a home run and three RBIs. Jeremy Peña also contributed with four hits, helping the Astros to a total of 14 hits in the game.

The Astros have been solid at the plate, with a team batting average of .254, ranking them 5th in the league. Their ability to make contact is evident, with 517 strikeouts, the 4th fewest in the league. This disciplined approach at the plate gives them a good chance to score runs in their upcoming game.

On the mound, Hunter Brown will start for the Astros, bringing an impressive ERA of 1.82. The Astros’ pitching staff has been strong, with a team ERA of 3.50, ranking 7th. Their ability to limit home runs, with only 64 given up, also ranks them 4th, making them a tough team to score against.

The Lean

The Astros are favored with a moneyline of -125, while the Twins are at +106. My model projects the Astros to win with a score of 4-3. The Astros have a stronger pitching staff, ranking 7th in ERA and 2nd in batting average against, which gives them an edge over the Twins.

The over/under line is set at 7.0. My model predicts a total score of 7 runs. Given the strong pitching from both teams, especially the Astros, taking the under is a solid choice. Both teams have mid-tier slugging percentages, which suggests a lower-scoring game.

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Astros Offense Thrives Despite Injuries

The Houston Astros opened their three-game series against the Minnesota Twins with a convincing 10-3 win on Friday night, showcasing the depth of their batting order. With Isaac Paredes sidelined due to a hamstring strain, the Astros shifted Yainer Diaz into the second spot in the lineup, sandwiched between Jeremy Peña and Jose Altuve. The move paid off.

Peña delivered a four-hit night, while Altuve drove in three runs. Diaz chipped in with a hit and a run scored, helping maintain the offensive momentum despite the lineup shuffle. Manager Joe Espada credited the lineup configuration for creating comfort and production around his core hitters.

Stay on top of the latest MLB insights and projected matchups by visiting the MLB previews page.

Hunter Brown Set for Start With League-Leading ERA

Right-hander Hunter Brown is scheduled to start Game 2 of the series on Saturday and enters the matchup with an 8-3 record and a league-best 1.82 ERA. Brown has been one of the most consistent starters in the American League this season, tied for first with 10 quality starts.

In his last outing, Brown allowed just one run over 5 1/3 innings against Cleveland, striking out nine despite issuing five walks. While he didn’t get the decision, he once again demonstrated his ability to limit damage and keep the Astros in the game.

Against Minnesota, Brown has been more hittable in his career, posting a 2-2 record and 5.16 ERA in five starts. However, he earned a win over the Twins earlier this season by allowing just two runs over six innings.

Want expert breakdowns and betting strategies for matchups like this one? Check out our MLB expert betting guide.

Joe Ryan Aims to Reverse Astros Struggles

The Twins will counter with right-hander Joe Ryan, who owns a strong 7-2 record and 2.96 ERA this season. Ryan has been especially sharp lately, going 6-0 with a 2.35 ERA over his last eight starts. He last pitched Sunday, allowing two earned runs in a 6-3 victory over the Blue Jays.

But the Astros have been a tough opponent for Ryan. In six career starts against Houston, he is 2-4 with a 7.58 ERA. In their April 3 meeting, he gave up four runs across five innings in a 5-2 loss.

If you’re looking to gain an edge on MLB picks and pitcher splits, browse our updated MLB picks section.

Lineup Adjustments Ahead for Minnesota

The Twins have been forced to adjust their lineup in response to facing three straight Astros left-handers this weekend. On Friday, only designated hitter Matt Wallner represented a strictly left-handed bat in the starting lineup. With another southpaw, Brandon Walter, expected to pitch in Sunday’s finale, Minnesota may continue with a righty-heavy look.

Twins manager Rocco Baldelli acknowledged the difficulty in keeping his left-handed hitters involved during a stretch dominated by opposing left-handed starters. He emphasized the importance of keeping those bats fresh and engaged, especially with a road series in Cincinnati up next.

Explore premium MLB picks and expert advice tailored to your betting needs at the Scores and Stats pick center.

Betting Outlook and Key Matchup Trends

Saturday’s game between Brown and Ryan offers a compelling pitching duel with contrasting historical trends. While Brown continues to solidify his Cy Young candidacy, Ryan will look to silence an Astros lineup that has given him trouble in the past. With Houston’s bats heating up and the Twins searching for lineup balance, this matchup could impact both team’s standings and momentum.

For those tracking top-performing MLB handicappers, visit our leaderboard of the best handicappers to see who’s trending up.

By T. Franklin Smith | April 8, 2025
By T. Franklin Smith | April 1, 2025
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Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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