Houston Astros vs Philadelphia Phillies June 25th 2025
The Philadelphia Phillies travel to Daikin Park to take on the Houston Astros. The game is set for Wednesday, June 25, 2025, at 8:10 PM. The Phillies, managed by Rob Thomson, hold a record of 47-32 this season. They have been strong on the road with a 21-18 record.
The Astros, led by manager Joe Espada, have a 46-33 record. Their home performance has been impressive with a 28-13 record. The Phillies will start Zack Wheeler, who has an ERA of 2.61, while the Astros will counter with Colton Gordon, who has an ERA of 4.54.
Phillies vs Astros Key Information
- Sport: Baseball
- Teams: Philadelphia Phillies vs. Houston Astros
- Venue: Daikin Park in Houston, TX
- Date: Wednesday, June 25, 2025
- Betting Odds: Phillies MoneyLine -163, Astros MoneyLine +137
The Phillies Can Win If…
The Philadelphia Phillies are coming off a narrow 0-1 loss to the Houston Astros. Ranger Suárez delivered a strong performance on the mound, pitching 7 2/3 innings with 7 strikeouts. Edmundo Sosa led the Phillies’ offense with two hits, including a double.
The Phillies have shown they can compete with their strong batting lineup. They rank 3rd in the league for both batting average (.256) and on-base percentage (.330). Kyle Schwarber is a key player, hitting 24 home runs and driving in 55 runs this season.
Philadelphia’s pitching is another strength. Zack Wheeler, their starting pitcher for the next game, has an ERA of 2.61 and a WHIP of 0.91. With Wheeler on the mound, the Phillies have a solid chance to secure a win against the Astros.
The Astros Can Win If…
The Houston Astros recently won a tight game against the Philadelphia Phillies, 1-0. Framber Valdez was key, pitching seven innings and allowing no runs. Cooper Hummel’s home run provided the only score, showing the team’s ability to win close games.
The Astros have a strong batting average, ranked second in the league at .257. Their pitching staff is also solid, with a 3.48 ERA, ranking fifth. These stats show that they have the tools to succeed on both offense and defense.
Jeremy Peña is a standout player, with a batting average of .326 and 11 home runs. Isaac Paredes adds power with 16 home runs, leading the team. With Colton Gordon on the mound, the Astros look to continue their winning ways against the Phillies.
The Lean
The Phillies are favored with a moneyline of -163, while the Astros are at +137. The Phillies have a strong batting average and on-base percentage, both ranked 3rd. With these stats, the model projects the Phillies to win with a score of 5-3.
The current over/under line is set at 7.5. The model projects a total score of 8 runs, suggesting the over is the better pick. Both teams show solid hitting stats, which supports the expectation for a higher scoring game.
Thriving Without Alvarez, Astros Face Phillies’ Ace Zack Wheeler
The Houston Astros are proving that their success is about the whole roster, not just one superstar. Despite being without slugger Yordan Alvarez for 48 games, the Houston Astros continue to win, showcasing incredible depth. They’ll face one of their toughest tests yet on Wednesday when they host the Philadelphia Phillies and their ace, Zack Wheeler.
The “Next Man Up” Mentality
The Astros have an impressive 30-18 record without Alvarez, who is recovering from a fractured hand. Tuesday’s 1-0 victory was a perfect example of their resilience, with utility player Cooper Hummel providing the game’s only run on a solo home run. It’s a culture that starts at the top.
“I feel like it’s the next-man-up mentality,” Astros manager Joe Espada said. “It’s everyone finding a way to help win games. Good teams do that, and we need that. It’s contagious.” How teams manage to thrive despite major injuries is a key topic in our expert betting guide.

The Wheeler Wall
Houston’s scrappy offense will have its hands full with Phillies ace Zack Wheeler (7-2, 2.61 ERA). The right-hander has been absolutely dominant in June, posting a minuscule 1.06 ERA over three starts this month while racking up 24 strikeouts in just 17 innings. He has a strong 1.50 career ERA against the Astros and will look to shut down their momentum.
A Duel of Opposites
While the Phillies have their established ace on the mound, the Astros will counter with rookie left-hander Colton Gordon (2-1, 4.54 ERA). Gordon has been a solid contributor for a Houston rotation that has dealt with its own season-ending injuries. He’ll be making his first career start against the Phillies. This matchup between a dominant ace and a serviceable rookie will be a major focus on the scores and odds board.
Philly’s Own Injury Watch
The Phillies are dealing with the absence of their own superstar, as first baseman Bryce Harper continues to work his way back from a wrist injury. While he is making progress, he is not expected to return during this series. The success of these MLB teams in the second half may depend on which one gets their slugger back to full health first. To see who our experts think will win this fantastic pitching matchup, check out our daily MLB picks.