Los Angeles Angels vs Houston Astros Picks and Predictions September 26th 2025

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Houston Astros vs Los Angeles Angels Betting Preview

The Houston Astros open a must-win series against the Los Angeles Angels on Friday night at Angel Stadium. Houston (85–74) is clinging to postseason hopes, one game behind Detroit for the final AL wild-card berth. The Angels (71–88) are locked into last place in the AL West but would relish playing spoiler.

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Houston snapped a five-game skid with an 11–5 win over Oakland on Thursday, fueled by Christian Walker’s homer and three RBIs. Manager Joe Espada said, “We’ve got three big games in Anaheim, and hopefully that momentum carries over.” The Angels counter with veteran Kyle Hendricks, possibly making his final MLB start. He denied retirement rumors, saying, “I’ve still got one more in the season. I’ll try and finish as strong as I can.”

Houston turns to Jason Alexander (4–2, 4.83 ERA), who struggled in his last outing against Seattle. Hendricks (8–10, 4.79 ERA) comes off seven scoreless innings against Colorado.

For context on recent team performance, review the MLB scoreboards to see how each side has fared leading up to this matchup.

Line Movement and Odds

  • Moneyline: Astros -148, Angels +126
  • Total: Over 9.0 (-108) / Under 9.0 (-113)

Books installed Houston as a road favorite given their playoff urgency and stronger statistical profile. The public is backing the Astros on both tickets and money, but sharper plays have appeared on the Angels’ moneyline at home. The total opened at 9.0, with early money shading to the over.

“Every one of these games matters. That’s no secret. We’ve got to win them all.” — Astros first baseman Christian Walker

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Matchup Breakdown

Houston Outlook
The Astros remain alive but cannot afford any slipups. Their lineup ranks top 10 in average (.250) and features pop from Christian Walker (24 HR, 85 RBIs) and consistency from Jeremy Peña (.304 BA). Houston’s staff has held opponents to a .233 batting average, fifth in MLB, but Jason Alexander’s recent form is shaky. If he can provide five innings, the bullpen and offense give Houston a real chance. The key will be avoiding early holes against Hendricks.

Los Angeles Outlook
The Angels are playing out the string but still have thump in the lineup. Taylor Ward and Jo Adell both sit at 36 homers, while the team ranks fifth in MLB with 220 total long balls. Hendricks, despite retirement chatter, silenced Colorado in his last start and can still frustrate lineups with his command. The Angels’ pitching staff overall has been an issue, with a team ERA of 4.86, but Hendricks’ swan song narrative adds energy to this spot.

Key Battle
Astros’ playoff desperation versus Hendricks’ veteran guile. Houston must jump on Hendricks early, as his best starts come when he settles into rhythm. If Hendricks can navigate the first trip through the order, the Angels’ bats have enough firepower to back him up. For Houston, keeping Angels sluggers in the park is essential.

Injuries and Conditions

AstrosAngels
• No new major injuries reported• No major injuries reported
• Jason Alexander starting• Kyle Hendricks starting
• Christian Walker hot at the plate• Taylor Ward, Jo Adell active and producing

Weather: Mild temperatures with broken clouds. Neutral hitting conditions expected in Anaheim.

Best Bets and Prediction

The Astros are the rightful favorite with everything to play for, but Hendricks’ command and Los Angeles’ home run power make this a dangerous matchup. Expect Houston’s offense to create chances against the Angels’ bullpen late.

  • Pick: Astros moneyline (-148)
  • Projected Score: Astros 6, Angels 4
  • Reasoning: Houston’s urgency and lineup depth outweigh Hendricks’ farewell start.
  • Lean: Over 9.0 — both teams feature power, and Alexander’s volatility makes high scoring more likely.
  • Market Split: ~67% tickets Astros, ~60% money Astros.
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CategoryDetail
Best BetAstros ML -148
Confidence★★★★☆
Projected ScoreAstros 6, Angels 4
Total LeanOver 9.0
Market Split67% tickets Astros, 60% money Astros

Handicappers and Picks

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For free actionable content, the MLB Picks page provides sides, totals, and props daily. And if you’re building your own approach, the Bettors Handbook teaches you how to manage your bankroll and spot line moves before they shift.

Stay disciplined in the final stretch — playoff baseball is all about sharp adjustments. Bet smarter with SAS.