Los Angeles Angels vs Houston Astros Picks and Predictions September 28th 2025

Los Angeles Angels vs Houston Astros September 28th 2025

The Houston Astros will take on the Los Angeles Angels at Angel Stadium of Anaheim. The Astros hold an 86-75 record and are ranked second in the AL West. They are coming off a win and have gone 4-6 in their last ten games. Their manager, Joe Espada, will look to guide the team to another victory.

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The Angels have a 72-89 record and are fifth in the AL West. They are on a one-game losing streak and have a 3-7 record in their last ten games. Ron Washington, the Angels’ manager, will aim to end the season on a positive note. The game is scheduled for Sunday, September 28, 2025, at 3:07 PM and will be broadcast on SCHN. The weather is expected to be mild with scattered clouds.

Astros vs Angels Key Information

• Sport: Baseball
• Teams: Houston Astros vs. Los Angeles Angels
• Venue: Angel Stadium of Anaheim, Anaheim, CA
• Date: Sunday, September 28, 2025
• Betting Odds: Astros Moneyline -125, Angels Moneyline +105

Astros vs Angels MLB Betting Preview

The Houston Astros (86-75) and Los Angeles Angels (72-89) finish their disappointing seasons on Sunday in Anaheim. For team stats and season breakdowns, visit the Astros team page and the Angels team page.

Houston snapped a playoff streak dating back to 2016, while the Angels extended theirs to 11 seasons without October baseball. Both clubs are aiming to close 2025 with momentum.

The Astros Can Win If…

Lance McCullers Jr. finds his command. The veteran righty owns a 6.71 ERA this season but has a strong career line against Los Angeles, going 7-5 with a 3.09 ERA. Houston’s bats must carry the rest. Christian Walker leads the team with 27 homers and Jeremy Peña adds balance with a .304 average.

The Astros’ staff leads MLB in strikeouts (1,495), giving them a clear edge if McCullers can settle in. Power support from Zach Cole and Walker, who both homered Saturday, would make Houston’s offense tough to match.

The Angels Can Win If…

Sam Aldegheri delivers a stable start. The rookie lefty (0-1, 8.00 ERA) showed improved command in his return from the minors, allowing three runs across 4 2/3 innings Tuesday. If he keeps the ball in the park, Los Angeles’ lineup can do the rest.

The Angels rank fourth in MLB with 225 homers, powered by Mike Trout, Taylor Ward, and Jo Adell. Trout already burned Houston with two homers in a Sept. 26 win. If the middle of the order drives runners in, the Angels can close with a victory.

Matchup Breakdown

• Astros: Houston ranks 8th in batting average (.251) and has enough offensive depth to pressure Aldegheri early. Their bullpen has been inconsistent but carries more reliability than the Angels’ staff.
• Angels: Power is their biggest weapon, ranking top five in HRs, but their ERA sits 28th overall. If Aldegheri falters, it will likely fall apart quickly.

For full numbers and line tracking, check the MLB odds board.

Best Bets and Prediction

Houston is favored at -125, while Los Angeles is +105. The total sits at 9.5 runs.

• Projected Score: Astros 6, Angels 4
• Best Bet: Astros moneyline -125
• Lean: Over 9.5 (-115) — both staffs allow runs, and home-run power should push this total higher.

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