Los Angeles Angels vs Kansas City Royals Picks and Predictions September 23rd 2025

The Kansas City Royals will take on the Los Angeles Angels at Angel Stadium of Anaheim. The Royals have a record of 78-78 and rank third in the AL Central. They are coming off a loss and have gone 4-6 in their last ten games.

The Angels hold a 70-86 record, placing them fifth in the AL West. They have struggled recently, with a 1-9 record in their last ten games. The game is set for Tuesday, September 23, 2025, at 9:38 PM, with clear skies expected.

Royals vs Angels Key Information

• Sport: Baseball
• Teams: Kansas City Royals vs. Los Angeles Angels
• Venue: Angel Stadium of Anaheim in Anaheim, CA
• Date: Tuesday, September 23, 2025
• Betting Odds: Royals Moneyline -152, Angels Moneyline +129, Royals Runline -1.5 (+108), Angels Runline +1.5 (-130), Total Over 8.5 (-116), Total Under 8.5 (-104)

The Royals Can Win If…

The Kansas City Royals are coming off a recent 8-5 loss to the Toronto Blue Jays. Despite the loss, the Royals’ offense showed promise with 10 hits. Mike Yastrzemski and Maikel Garcia each contributed two hits, while Jac Caglianone added a triple.

The Royals have a strong lineup that can deliver results. They rank 4th in the league with 277 doubles this season. Vinnie Pasquantino is a key player, leading the team with 31 home runs and 107 RBIs.

Cole Ragans will start for the Royals with a 5.16 ERA. He faces off against Sam Aldegheri, who has a 10.38 ERA. The Royals have a better chance with their pitching matchup, as Aldegheri has struggled in his appearances.

The Angels Can Win If…

The Los Angeles Angels are coming off a close 3-1 loss to the Colorado Rockies. Despite the loss, the Angels had seven hits, with Mike Trout and Jo Adell contributing. Caden Dana pitched six innings, allowing only three hits and striking out five batters.

The Angels have a strong power game, ranking 4th in the league with 217 home runs this season. Taylor Ward and Jo Adell are key contributors, with 34 and 36 home runs, respectively. This power gives the Angels the ability to score quickly and change the game’s momentum.

Looking ahead, the Angels will rely on Sam Aldegheri as their starting pitcher. While his ERA is high, the Angels’ offense can provide the support needed. With hitters like Mike Trout and Nolan Schanuel in the lineup, the Angels have the potential to put runs on the board against the Royals.

Latest Betting Trends

• Kansas City enters the series at .500 but has dropped four of its last five road games.
• The Royals are 2-6 in Cole Ragans’ last eight starts dating back to May.
• Los Angeles is just 1-9 in its last 10 games, including a series loss to Colorado.
• The Angels have gone under the total in six of their last eight home games.
• Kansas City has won six of its last eight meetings with the Angels.

The Lean

The Royals have a moneyline of -152, while the Angels are at +129. The Royals have a stronger pitching staff with a 3.77 ERA, ranked 6th, compared to the Angels’ 4.86 ERA, ranked 28th. With this advantage, the model projects a Royals win with a score of 5-3. Thus, the recommendation is to pick the Royals to win straight up.

The total line is set at 8.5 runs. The Royals’ pitching strength suggests a lower scoring game, while the Angels’ batting average ranks 23rd. The model projects a total of 8 runs. Therefore, the recommendation is to take the under at 8.5 runs.

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Royals Facing Long Odds in Final Week

The Kansas City Royals begin their final six-game road trip on Tuesday against the Los Angeles Angels, knowing their postseason hopes are hanging by a thread. At 78-78, the Royals are six games back of the last American League wild-card spot with six to play. To even have a chance, Kansas City must sweep the Angels and then the Oakland Athletics. Even then, a single win by either Houston or Cleveland would officially eliminate them.

For bettors following the race closely, you can track updated matchups and insights on the MLB previews page

Cole Ragans Returns From Injury

Left-hander Cole Ragans (2-3, 5.16 ERA) takes the mound in Tuesday’s opener for Kansas City. The 2024 breakout star, who struck out 223 batters over 186 1/3 innings last season, has battled multiple injuries in 2025. After missing three months with a rotator cuff strain, Ragans returned last week against Seattle, flashing his dominant fastball by striking out Randy Arozarena, Cal Raleigh, and Julio Rodriguez on 11 pitches in the first inning.

He allowed two runs in 3 2/3 innings and will look to stretch out further against the Angels. With his focus on preparing for 2026, Kansas City hopes Ragans can reestablish himself as the ace of the staff. Fans and bettors can follow his performance through the latest MLB game results

Angels Give Sam Aldegheri the Ball

The Angels will counter with left-hander Sam Aldegheri (0-0, 10.38 ERA). He struggled earlier this season in two relief appearances, including a disastrous outing against Texas where he allowed five runs in two innings. After refining his approach in the minors, Aldegheri posted a 2.52 ERA over nine Double-A starts and one Triple-A outing, earning another shot at the big-league level.

For a deeper look at betting strategies on developing pitchers like Aldegheri, visit the MLB expert betting guide

Teams Playing Out the String

While Kansas City is clinging to faint postseason math, the Angels have long been out of contention. Sitting at 70-86, they’ve secured their 10th straight losing season and will miss the playoffs for the 11th year in a row. Los Angeles comes home after a 1-9 road trip that included losing two of three to the lowly Rockies.

For those seeking daily predictions on teams finishing the season, check the updated MLB picks page

Betting Perspective and What’s Next

From a wagering standpoint, this matchup highlights two organizations evaluating talent for the future rather than competing for playoff position. Ragans will make one more start against Oakland to close the year, while Aldegheri aims to prove he belongs in the Angels’ rotation plans for 2026.

Bettors looking for stronger insights can find top-rated selections from leading handicappers on the MLB buy picks page and the best handicappers leaderboard