Los Angeles Angels vs Minnesota Twins Picks and Predictions September 10th 2025

Los Angeles Angels vs Minnesota Twins September 10th 2025

The Minnesota Twins will take on the Los Angeles Angels at Angel Stadium of Anaheim. The Twins have a record of 64-80 and are ranked fourth in the AL Central. They are on a two-game winning streak but have struggled in their last 10 games, going 3-7. Manager Rocco Baldelli will look to improve their road record, which currently stands at 29-44.

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The Angels hold a record of 67-77, also sitting fourth in their division, the AL West. They have split their last 10 games, going 5-5, and are coming off a loss. Ron Washington’s team will aim to leverage their home-field advantage, where they have a 35-38 record. The game is set for Wednesday, September 10, 2025, at 4:07 PM, and will be aired on MNNT.

Twins vs Angels Key Information

• Sport: Baseball
• Teams: Minnesota Twins vs. Los Angeles Angels
• Venue: Angel Stadium of Anaheim, Anaheim, CA
• Date: Wednesday, September 10, 2025
• Betting Odds:
  • Twins Moneyline: +117
  • Angels Moneyline: -138
  • Twins Runline: +1.5 (-179)
  • Angels Runline: -1.5 (+150)
  • Total Over: 9.0 (-106)
  • Total Under: 9.0 (-114)

The Twins Can Win If They Stay Aggressive at the Plate

The Minnesota Twins showed flashes of their offensive potential with a 12-3 blowout win in the series opener, thanks to two home runs from Royce Lewis and a three-hit night from Luke Keaschall. This is a team that ranks 11th in the league in home runs and 12th in on-base percentage — enough to put pressure on any opposing pitcher when the bats are hot.

Byron Buxton, who is having a quietly strong year with a .271 average and 30 home runs, could be the X-factor. If Taj Bradley can keep the game under control early, Minnesota’s power-hitting lineup has the tools to put up another crooked number and walk away with a road series win.

The Angels Can Win If Soriano Settles In

The Los Angeles Angels erupted for 12 runs and 17 hits in Game 2 of the series, showcasing what their lineup can do when everything clicks. José Soriano now takes the mound in the rubber match, looking to bounce back from his worst start of the season where he allowed eight runs in just 2.1 innings against the A’s.

Despite those struggles, Soriano has been lights-out on the road and will look to bring some of that focus back to Anaheim. If sluggers like Zach Neto and Jo Adell (who missed the last two games with vertigo) are back in the lineup, and if Soriano can limit early damage, the Angels are in a good spot to close out the series

The Lean

• Moneyline: Angels -138
• Total: 9.0 runs
• Prediction: Angels 5, Twins 4

Recommended Bets:

• Pick: Angels ML (-138)
• Total: Over 9.0 (-106)

The Angels’ bats have come to life, and despite Soriano’s home ERA issues, Minnesota’s inconsistency gives LA a slight edge. Both pitchers have ERAs near or above 5.00, so the over has strong appeal.

Momentum Swings, Pitching Struggles, and Matchup History

The Angels ended a six-game losing streak to the Twins with their blowout win Tuesday. They also scored all 12 runs with two outs, something they’ve only done one other time in franchise history — ironically, against the Twins in 1962.

That level of clutch hitting, combined with the Twins’ recent bullpen woes and Taj Bradley’s 7.20 ERA since joining the team, swings momentum toward Los Angeles.

That said, Bradley has decent career numbers vs. the Angels (1 ER over 5 IP last year) and could steady himself if he gets early run support. But Soriano’s ability to recover from his previous outing — and continue his dominance against weaker lineups — could be the story of the day.

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