Los Angeles Dodgers vs Minnesota Twins Picks and Predictions July 21st 2025

Los Angeles Dodgers vs Minnesota Twins MLB Mon, Jul 21, 21:10 pm.
Los Angeles Dodgers
ML: -213
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Minnesota Twins
ML: 165
Last Updated on

The Minnesota Twins are set to play against the Los Angeles Dodgers at Dodger Stadium. This night game will begin at 10:10 PM on Monday, July 21, 2025. Fans can catch the game on SN LA.

The Twins come into this game with a 48-51 record. They have struggled on the road with a 20-31 record. On the mound for the Twins will be David Festa, who has a 5.25 ERA. The Dodgers have a 58-42 record and are strong at home with a 33-20 record. Shohei Ohtani will start for the Dodgers, boasting a 1.00 ERA.

Twins vs Dodgers Key Information

  • Sport: Baseball
  • Teams: Minnesota Twins vs. Los Angeles Dodgers
  • Venue: Dodger Stadium in Los Angeles, CA
  • Date: Monday, July 21, 2025
  • Betting Odds: Twins Moneyline +174, Dodgers Moneyline -207, Twins Runline +1.5 (-115), Dodgers Runline -1.5 (-105), Total Over 9.0 (-104), Total Under 9.0 (-116)

The Twins Can Win If…

The Minnesota Twins are coming off a strong win against the Colorado Rockies, taking the game 7-1. Joe Ryan was dominant on the mound, pitching seven innings and striking out 11 batters. Royce Lewis and Matt Wallner powered the offense with home runs, showing their potential to change the game quickly.

The Twins have some impressive stats that give them a chance to win. They rank 10th in home runs with 118, showing they can score quickly. Their pitching staff has also been effective, ranking 9th in home runs given up, which can keep the Dodgers’ offense in check.

Two Minnesota Twins players celebrating with a high five during a baseball game

Key players like Byron Buxton and Carlos Correa can make a difference. Buxton leads the team with 22 home runs, and Correa contributes with a .267 batting average. With David Festa starting, the Twins will look to support him with strong defense and timely hitting against the Dodgers.

The Dodgers Can Win If…

The Los Angeles Dodgers recently played against the Milwaukee Brewers and lost 5-6. Despite the loss, Shohei Ohtani hit a home run and drove in two runs. Esteury Ruiz also contributed with a home run, showing the team’s power potential.

Looking at the season stats, the Dodgers have a strong offense. They rank 2nd in home runs with 150 and 3rd in on-base percentage at .328. Their lineup includes top hitters like Ohtani and Will Smith, who have impressive batting averages and slugging percentages.

Dodgers player during a professional baseball game

Shohei Ohtani will be the starting pitcher for the Dodgers in the next game. He has an ERA of 1.00 and a WHIP of 0.78, indicating his effectiveness on the mound. With Ohtani pitching and hitting, the Dodgers have a good chance to win against the Twins.

The Lean

The Dodgers are favored with a moneyline of -207 against the Twins at +174. The Dodgers have a higher batting average and on-base percentage, ranking 5th and 3rd respectively. The Twins rank lower in these areas, at 15th for both. Based on the stats, my model projects the Dodgers to win 6-4. I recommend picking the Dodgers to win straight up.

The total for this game is set at 9.0. The Dodgers have a strong offense with 150 home runs, ranking 2nd, while the Twins have allowed 104 home runs, ranking 9th. My model projects a total score of 10 runs. Given these factors, I recommend taking the over on the total.

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Dodgers Rely on Shohei Ohtani to Halt Slide vs. Twins

The Los Angeles Dodgers will turn to Shohei Ohtani’s two-way brilliance as they host the Minnesota Twins on Monday in the opener of a three-game series. After a brutal stretch that has seen them lose 10 of their past 12 games, including back-to-back sweeps at the hands of the Milwaukee Brewers, the Dodgers are desperate for a spark.


Struggling to find winning plays? Get sharper insights with proven MLB betting experts before first pitch.

Ohtani Back on the Mound—and in the Spotlight

Ohtani (0-0, 1.00 ERA) continues his gradual return as a regular starter following Tommy John revision surgery. He’s expected to throw three innings Monday, with Dustin May available to piggyback out of the bullpen.

“The goal is to go three innings and then we’ve got Dustin May to take down as much of the game as we need behind him,” Dodgers manager Dave Roberts said.

Despite the team’s struggles, Ohtani continues to deliver. He blasted a two-run homer Sunday in a 6-5 loss to Milwaukee, snapping a personal mini-slump at the plate while extending the Dodgers’ home losing streak to six games—their longest since 2017.

“He’s doing everything we need from him,” Roberts added after Sunday’s loss.

Historically, Ohtani has dominated the Twins, going 1-0 with a 2.08 ERA in three career starts while striking out 27 batters in 17 1/3 innings. As a hitter, he’s batting .301 against Minnesota with six homers and 14 RBIs in 24 games.

Dodgers Shuffle Lineup Amid Struggles

In an effort to shake up the offense, Mookie Betts was moved back into the leadoff spot Sunday, with Ohtani dropping to second in the order. Betts, hitting just .195 over his past 21 games and .107 over his last seven, welcomed the move.

“I’m a team guy. I want the boys to play well,” Betts said. “I want us to win. If I’m not performing, there’s no reason I should be on the field to play.”

Looking to see if this lineup tweak sparks the Dodgers’ bats? Check out our latest MLB Predictions and Picks for key betting angles.

Twins Counter with Festa After Big Win

Minnesota will send right-hander David Festa (3-3, 5.25 ERA) to the mound. Festa is coming off a solid outing against the Cubs, allowing just two runs over 5 1/3 innings. He’s won two of his last three starts after struggling early in the season.

“Obviously, I think it’s cool to face some of the better guys in the game, but at the end of the day, all these guys are good,” Festa said. “You kind of have to handle it the same way, but it will be cool to go up against (Ohtani) and, obviously, a really great team like the Dodgers.”

The Twins avoided a sweep in Colorado with a 7-1 win Sunday, powered by Royce Lewis’ first career multi-homer game. Lewis, a Southern California native, will play in front of family and friends for the first time as a big leaguer in L.A.


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With Ohtani taking the mound and both teams battling for momentum, Monday’s matchup offers prime betting value. Whether you’re backing the Dodgers to break their slump or the Twins to keep rolling, stay ahead with our MLB Picks and Analysis.