Los Angeles Dodgers vs St. Louis Cardinals Picks and Predictions August 6th 2025

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The St. Louis Cardinals will play against the Los Angeles Dodgers at Dodger Stadium. The Cardinals have a record of 57-57 and are fourth in the NL Central. They have won their last game but are 4-6 in their last ten games.

The Dodgers have a record of 65-48 and lead the NL West. They lost their last game and have a 5-5 record in their last ten games. The game is set for Wednesday, August 6, 2025, at 4:10 PM and will be aired on FDSMW.

Cardinals vs Dodgers Key Information

  • Sport: Baseball
  • Teams: St. Louis Cardinals vs. Los Angeles Dodgers
  • Venue: Dodger Stadium in Los Angeles, CA
  • Date: Wednesday, August 6, 2025
  • Betting Odds: Cardinals Moneyline +176, Dodgers Moneyline -210, Cardinals Runline +1.5 (-114), Dodgers Runline -1.5 (-106), Total Over 9.0 (-102), Total Under 9.0 (-119)

The Cardinals Can Win If…

The St. Louis Cardinals recently secured a 3-2 win against the Los Angeles Dodgers. Sonny Gray was impressive on the mound, allowing just one hit over seven innings and striking out eight. Iván Herrera and Masyn Winn contributed with key home runs, showcasing their ability to change the game with a single swing.

St. Louis ranks 5th in doubles this season, with 198, showing their knack for extra-base hits. Their ability to stretch singles into doubles can put pressure on the opposing defense. With players like Alec Burleson and Willson Contreras leading in home runs, the Cardinals have the power to score runs quickly.

Matthew Liberatore will be the starting pitcher for the Cardinals, holding a 3.96 ERA. His ability to limit walks, with a WHIP of 1.27, keeps runners off base. If he can maintain his control, the Cardinals’ defense can support him to secure another win.

The Dodgers Can Win If…

The Los Angeles Dodgers are looking to bounce back after a close 3-2 loss to the St. Louis Cardinals. In that game, Tyler Glasnow pitched well, allowing only one run over seven innings. Freddie Freeman hit a home run, showing his ability to contribute offensively.

The Dodgers have strong hitting stats this season. They rank 3rd in on-base percentage and slugging percentage. Their 165 home runs place them 2nd in the league, indicating their power at the plate.

Shohei Ohtani will take the mound for the Dodgers. His ERA of 2.40 shows his effectiveness as a pitcher. With Ohtani’s skills and the Dodgers’ powerful lineup, they have a good chance to win this game.

The Lean

The Dodgers are favored with a moneyline of -210, while the Cardinals are at +176. The Dodgers have a stronger hitting lineup, ranking 3rd in slugging percentage and home runs. My model projects the Dodgers to win with a score of 6-4. Based on these factors, the recommendation is to pick the Dodgers to win straight up.

The total for the game is set at 9.0 runs. Both teams have pitching ERAs over 4.00, indicating potential for runs. My model projects a total score of 10 runs. Given the hitting strengths and pitching weaknesses, the recommendation is to take the over at 9.0 (-102).

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Shohei Ohtani Returns to Mound as Dodgers’ Offense Explodes in Rubber Match vs. Cardinals

A week after a hip cramp sent a collective scare throughout the city of Los Angeles, Shohei Ohtani is ready to return to the pitcher’s mound. The two-way superstar will make his seventh start of the season on Wednesday afternoon as the Los Angeles Dodgers look to clinch their series against the visiting St. Louis Cardinals in a decisive rubber match. Ohtani’s return comes at the perfect time, as the Dodgers’ potent offense finally woke up in a massive way on Tuesday, providing a glimpse of the juggernaut this team was built to be.

The Ohtani Experiment Continues

The Dodgers are continuing their slow and methodical ramp-up of their most unique weapon. Ohtani (0-0, 2.40 ERA) is once again expected to be limited to around four innings on Wednesday as he continues to build up his arm strength following his 2023 Tommy John revision surgery. His last outing was a bit shaky; he was spraying pitches and eventually had to leave early with a hip cramp on a hot and muggy evening. While the injury turned out to be minor, it was a stark reminder of the delicate balance the Dodgers must strike in managing the health of a player who is elite as both a pitcher and a hitter.

The physical toll of returning to two-way duties may have shown up in his offensive numbers in July, as Ohtani hit just .231 for the month. However, his elite power never waned, as he still managed to launch nine home runs. He enters Wednesday’s game on a five-game hitting streak, a sign that he is finding his rhythm at the plate again even as he resumes his duties on the mound. In his only career start against the Cardinals, he was electric, striking out 13 batters, though he also gave up four runs.

The statistical comparison between these two clubs shows the clear advantage the Dodgers have on paper, especially on the offensive side of the ball.

TeamRecordDivision StandingRuns Per GameTeam ERA
Los Angeles Dodgers73-451st in NL West5.34.05
St. Louis Cardinals62-582nd in NL Central4.54.30

An Offensive Awakening in LA

While Ohtani is the main event, the biggest story from Tuesday’s 12-6 victory was the explosive awakening of the entire Dodgers lineup. After a period of frustrating inconsistency, the offense put on a show, pounding out 17 hits. The charge was led by Max Muncy, who was making his first start after a month on the injured list with a knee injury. Muncy looked like he hadn’t missed a beat, blasting two home runs and driving in four. “I was getting to the pitches at the top of the zone,” a confident Muncy said. “As long as I’m doing that, I feel like my swing is in a really good spot.”

He was joined by Mookie Betts, who finally broke out of a deep 0-for-22 slump with three hits of his own. The relief in the clubhouse was palpable, though Betts was humorously cautious. “It’s good to get the results, but it’s one game,” he said. “Every time we talk about this, I go 0-for-20 after. So we’ll see about tomorrow.” The psychology of a superstar breaking out of a slump is a key topic in our expert betting guide.

The Pitching Matchup: A Deeper Look

Wednesday’s game features a fascinating duel. Ohtani will look to continue his successful return to the mound, while the Cardinals will counter with a lefty who has been excellent as a starter but has struggled against the Dodgers in his career. The scores and odds for this matchup will heavily favor the home team.

PitcherW-L (2025)ERA (2025)Career vs. Opponent
Shohei Ohtani (LAD)0-02.4013 K’s in 1 Start
Matthew Liberatore (STL)6-93.967.27 ERA (6 games)

The Cardinals will turn to left-hander Matthew Liberatore (6-9, 3.96 ERA), who has been a steady and effective part of their rotation, allowing two or fewer earned runs in six of his last seven starts. However, in six career relief appearances against the Dodgers, he has a 7.27 ERA. This will be his first career start against Los Angeles, and he will have to be at his best to navigate their powerful lineup. For more in-depth analysis of other games, you can view all of our MLB previews. You can also review the most recent MLB game results to see their latest form. To see who our experts are backing, check out our daily MLB picks. To get access to even more premium content and betting tools, you can register for an account today.