Miami Marlins vs Chicago Cubs Picks and Predictions May 21st 2025

Cubs vs Marlins

The Chicago Cubs visit loanDepot park to face the Miami Marlins in the rubber game of their three-game series on Wednesday, May 21 at 1:10 PM ET. Expect mostly sunny skies, warm and humid conditions with afternoon breezes, a high near 94°F and a low around 78°F.

Cubs’ Offensive Surge

Chicago erupted for a season-high 14 runs Tuesday, fueled by Seiya Suzuki’s two-run homer and an eight-run sixth inning. The 21-hit attack demonstrated the lineup’s depth, setting the tone for a confident Cubs squad seeking consecutive dominant performances.

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Marlins’ Resilience Tested

Miami’s lone run came via Nick Fortes’s homer, but the bullpen faltered under relentless pressure. Manager Clayton McCullough will need to rally his relievers after Tuesday’s struggles and rely on fresh arms to stymie another potent Cubs offense.

Pitching Matchup

The Cubs hand the ball to Cade Horton (2-0, 6.00 ERA), fresh off his first MLB win, while the Marlins counter with Max Meyer (3-4, 4.47 ERA). Horton’s competitiveness and Meyer’s improving command will clash in a pivotal mid-week matchup where innings length could decide the outcome.

X-Factors and Strategy

Ian Happ’s return from injury adds punch at the top of Chicago’s order, and rookie Matt Shaw’s hot bat further bolsters depth. Miami’s bullpen usage and ability to limit big innings will be crucial. At loanDepot park, defensive shifts and pitch sequencing often tilt close games.

Our MLB Best Bets

Backing the Cubs on the money line is compelling given their recent explosion and Horton’s confidence. For added value, consider the over on total runs—this series has produced high scoring, and both staffs carry question marks in relief.