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Chicago Cubs vs Milwaukee Brewers NLDS Game 2 Betting Preview
The Milwaukee Brewers look to take a commanding 2-0 lead over the Chicago Cubs in their National League Division Series when they meet for Game 2 on Monday, October 6, 2025, at American Family Field. First pitch is set for 9:08 PM ET on TBS.
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Milwaukee struck first in the series, blasting their way to a 9-3 victory in Game 1, powered by a dominant performance from Freddy Peralta and clutch hitting from Jackson Chourio.
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Line Movement and Odds
- Opening Line: Brewers –118 / Cubs +101 / Total 8.0 (–110)
- Current Line: Brewers –121 / Cubs +103 / Total 8.0 (Over –108 / Under –113)
- Runline: Cubs +1.5 (–203) | Brewers –1.5 (+171)
- Market Action: Public split roughly 57% bets Brewers, 60% money on Cubs (sharps backing road value).
Milwaukee continues to see strong home support, as American Family Field remains one of the toughest environments in the postseason. Chicago’s bullpen imploded late in Game 1, allowing five runs over the final three innings.
“We’ve got to attack earlier in counts and stop giving away free bases,” Cubs manager Craig Counsell said after the loss. “Our lineup will bounce back.”
With rain in the Milwaukee forecast and the retractable roof likely closed, offensive conditions should remain neutral.
Matchup Breakdown
Chicago Cubs Outlook
The Cubs’ bats showed flashes despite the Game 1 defeat. Michael Busch, Ian Happ, and Nico Hoerner each homered, and the team continues to flash power depth that ranked 5th in MLB in slugging (.430) and 6th in home runs (223) this season.
Shota Imanaga takes the ball with a 3.73 ERA and 0.99 WHIP, featuring pinpoint control that has limited base traffic all year. Chicago’s path to victory rests on timely power and keeping Milwaukee’s base runners contained.
Milwaukee Brewers Outlook
Milwaukee’s Game 1 performance showcased their depth and discipline. Jackson Chourio went 3-for-3 with three RBIs, while William Contreras and Brice Turang continued their productive playoff stretches. The Brewers finished 2nd in MLB in team average (.258) and on-base percentage (.331), backed by an elite pitching staff ranked 2nd in ERA (3.59).
Left-hander Aaron Ashby will start Game 2, entering with a 2.16 ERA and 5-2 record. His command of the zone and soft-contact tendencies are ideal against a Cubs lineup reliant on power.
Injuries and Conditions
| Chicago Cubs | Milwaukee Brewers |
|---|---|
| RP Adbert Alzolay (elbow) – Out | 3B Andruw Monasterio (ankle) – Day-to-day |
| OF Pete Crow-Armstrong (shoulder) – Out | RP Trevor Megill (forearm) – 15-day IL |
| SP Justin Steele (forearm) – Out for series | RP Elvis Peguero (lat) – 15-day IL |
Weather: 63°F with light rain expected, roof likely closed. Slight humidity may enhance ball carry once the roof opens post-storm.
Best Bets and Prediction
Milwaukee’s lineup looks deeper and more consistent top to bottom, and Ashby’s recent form gives them the advantage over Imanaga. The Cubs’ bullpen remains a liability in close games, especially on the road.
Pick: Brewers ML (–121)
Projected Final Score: Brewers 5, Cubs 4
Lean: Over 8.0 (–108)
The Cubs’ bats will make noise, but Milwaukee’s situational hitting and bullpen reliability make the difference. For more MLB Analysis and Daily Picks, visit the MLB Previews section.
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| Category | Detail |
|---|---|
| Best Bet | Brewers ML (–121) |
| Confidence Rating | ★★★★☆ |
| Projected Score | Brewers 5 – Cubs 4 |
| Total Lean | Over 8.0 (–108) |
| Market Split | 57% bets Brewers, 60% money Cubs (sharp lean road side) |
ScoresAndStats Handicappers and Picks
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