Milwaukee Brewers vs Cincinnati Reds Picks and Predictions September 26th 2025

Milwaukee Brewers vs Cincinnati Reds September 26th 2025

The Cincinnati Reds visit the Milwaukee Brewers at American Family Field. The Reds hold a record of 81-78 and are third in the NL Central. They have a recent streak of one win and have gone 7-3 in their last ten games. Their road record stands at 36-42 this season.

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The Brewers, leading the NL Central, have a record of 96-63. They also have a one-game win streak and are 5-5 in their last ten games. At home, they have performed well with a 51-27 record. The game features starting pitchers Zack Littell for the Reds and Quinn Priester for the Brewers. Littell has a 3.86 ERA, while Priester has a 3.25 ERA. The game airs on FDSWI at 8:10 PM.

Reds vs Brewers Key Information

• Sport: Baseball
• Teams: Cincinnati Reds vs. Milwaukee Brewers
• Venue: American Family Field in Milwaukee, WI
• Date: Friday, September 26, 2025
• Betting Odds: Reds Moneyline +139, Brewers Moneyline -164, Reds Runline +1.5 (-154), Brewers Runline -1.5 (+129), Total Over 8.0 (-116), Total Under 8.0 (-104)

The Reds Can Win If…

The Cincinnati Reds recently secured a 2-1 win against the Pittsburgh Pirates. Nick Lodolo was outstanding, pitching 6 1/3 innings with 12 strikeouts and allowing only two hits. TJ Friedl contributed with two hits, including a double, showcasing his ability to get on base and score runs.

The Reds’ pitching staff has been solid this season, with a team ERA of 3.88, ranking 12th in the league. They have also been effective at keeping opponents’ batting averages low, with a .234 average against, which is 6th best. Their ability to deliver quality starts, ranking 4th with 69, gives them a chance to win every game.

Offensively, Elly De La Cruz stands out with a .264 batting average and 21 home runs. His contributions, along with Noelvi Marte’s .270 average, provide a strong foundation for the lineup. With Zack Littell starting, who has a 3.86 ERA, the Reds have a reliable arm to lead them to victory against the Brewers.

The Brewers Can Win If…

The Milwaukee Brewers recently secured a 3-1 victory over the San Diego Padres. Chad Patrick pitched three innings, allowing only two hits and striking out six. Danny Jansen contributed with a home run, while Brice Turang added three hits and an RBI.

The Brewers are strong in key stats this season. They hold the second-best batting average in the league at .260 and lead in on-base percentage at .332. Their pitching staff is also formidable, with a team ERA of 3.61, ranked second in the league.

Quinn Priester will start for the Brewers in the upcoming game. Priester has an impressive 13-2 record with a 3.25 ERA. With a strong lineup and solid pitching, the Brewers have the tools to secure another win.

The Lean

The Brewers are favored with a moneyline of -164. My model projects the Brewers to win with a score of 5-3. Considering their strong batting average and earned run average, the Brewers are the pick to win this game.

The total for the game is set at 8.0. My model projects a total score of 8, matching the line. Given the pitching strength of both teams, the under 8.0 at -104 is the recommended pick.

Reds vs Brewers MLB Betting Preview

The Cincinnati Reds (81-78) travel to Milwaukee to open their final series Friday with postseason hopes still alive. Cincinnati sits one game behind the Mets for the final NL wild-card spot, while Milwaukee (96-63) has already clinched the NL Central and is one win away from securing the league’s top overall seed. For full season data, visit the Cincinnati Reds team page.

Milwaukee has tied a franchise record for wins and continues to ride the consistency of Quinn Priester, who has been nearly automatic. More context is available on the Milwaukee Brewers team page.

Line Movement and Odds

Milwaukee opened around -155 with Priester on the mound. The total is set at 8 runs. Public money has tilted heavily toward the Brewers, while sharper splits have cautiously backed the Reds given their must-win urgency. Track updates live on the MLB odds page.

Matchup Breakdown

Reds: Zack Littell (10-8, 3.86 ERA) has battled home run issues this month, allowing six across 21 innings. Still, he won his last outing against the Cubs and owns a 1.71 ERA across 11 career appearances against Milwaukee. Cincinnati enters off a 2-1 win over Pittsburgh where Nick Lodolo struck out 12 before exiting with a precautionary groin injury.

Brewers: Priester (13-2, 3.25 ERA) has been dominant since May, winning 12 straight decisions. The Brewers are 19-0 in his last 19 outings, a run that underscores their playoff ceiling. He’s 1-0 with a 2.76 ERA lifetime vs Cincinnati and struck out 10 in his last start.

Both clubs have pitching depth aligned, with Milwaukee looking to close out the top seed and Cincinnati fighting to extend its season.

Injuries and Conditions

• Reds: Lodolo (groin) day-to-day. Outfielder Noelvi Marte remains healthy after a highlight-reel catch Thursday.
• Brewers: No new injuries, rotation aligned for October.

Weather: Roof likely closed at American Family Field, neutralizing conditions.

Best Bets and Prediction

Priester’s streak speaks for itself, but the Reds’ urgency and Littell’s past success against Milwaukee make this a tricky cap. Bettors should weigh the public lean against the line value on Cincinnati.

Projected score: Brewers 4, Reds 3
Best Bet: Brewers moneyline -155
Lean: Under 8 runs (Priester’s form, playoff atmosphere)

For more betting breakdowns, see the MLB picks section and sharpen your strategy with the MLB expert betting guide.