Milwaukee Brewers vs San Francisco Giants Picks and Predictions August 22nd 2025

Milwaukee Brewers vs San Francisco Giants August 22nd 2025

The San Francisco Giants are set to play against the Milwaukee Brewers at American Family Field. The game will take place on Friday, August 22, 2025, at 8:10 PM. The Giants have a record of 61-67 and are ranked fourth in their division. They are currently on a three-game losing streak and have won only 2 of their last 10 games.

The Milwaukee Brewers hold an impressive record of 80-48, leading the NL Central division. They have won six of their last 10 games. The Brewers recently secured a win in their last game. The starting pitchers will be Carson Whisenhunt for the Giants and Jose Quintana for the Brewers. The game will be broadcast on NBCS, and the weather is expected to be warm with clear skies.

Giants vs Brewers Key Information

• Sport: Baseball
• Teams: San Francisco Giants vs. Milwaukee Brewers
• Venue: American Family Field in Milwaukee, WI
• Date: Friday, August 22, 2025
• Betting Odds: Giants Moneyline +144, Brewers Moneyline -171, Giants Runline +1.5 (-149), Brewers Runline -1.5 (+125), Total Over 8.5 (-109), Total Under 8.5 (-111)

The Giants Can Win If…

The San Francisco Giants are looking to bounce back after a recent loss to the San Diego Padres. Despite the 8-4 defeat, the Giants showed power with two home runs from Willy Adames and Rafael Devers. Luis Matos also contributed with two hits, including a double and a triple, showcasing the team’s potential to score.

The Giants have a solid pitching staff, ranking 7th in the league with a 3.77 ERA. Their ability to limit home runs is a strength, as they have given up the fewest in the league with 112. With Carson Whisenhunt on the mound, the Giants will aim to leverage their pitching to secure a win.

Rafael Devers is a key player for the Giants, with 25 home runs and 83 RBIs this season. His performance at the plate can be a game-changer. The lineup also includes other strong hitters like Willy Adames and Wilmer Flores, who can provide the necessary support to clinch a victory.

The Brewers Can Win If…

The Milwaukee Brewers are coming off a strong 4-1 win against the Chicago Cubs. In that game, Brice Turang was a standout performer, going 2-for-4 with a home run and two RBIs. Sal Frelick also contributed with two hits, including a double, showing the depth in the Brewers’ lineup.

The Brewers have a solid batting average of .258, which ranks second in the league. Their ability to get on base is evident with an on-base percentage of .330, ranking third. With Jose Quintana on the mound, who has a 3.32 ERA, the Brewers have a reliable pitcher to start the game.

Brice Turang leads the team in several categories, including home runs and RBIs. His performance, along with Christian Yelich’s power, gives the Brewers a potent lineup. The Brewers’ pitching staff has also been effective, holding opponents to a .228 batting average, which is second in the league.

The Lean

The Brewers are favored with a moneyline of -171, and they have strong stats in batting and pitching. Their batting average ranks 2nd in the league, and their ERA is 3rd. The Giants have a lower batting average and a higher ERA. My model projects the Brewers to win with a score of 5-3. The recommendation is to pick the Brewers to win straight up.

The total for the game is set at 8.5 runs. The Brewers have a solid offense, but the Giants’ pitching ranks 7th in ERA, which could limit scoring. My model projects a total score of 8 runs. The recommendation is to take the under at 8.5.

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Milwaukee Regains Momentum

The Milwaukee Brewers snapped a three-game skid with a 4-1 victory over the Chicago Cubs on Thursday, reaching 80 wins — the best mark in Major League Baseball. That win extended their National League Central lead to seven games and set the tone for their weekend matchup against the San Francisco Giants. Bettors looking to follow hot teams like Milwaukee can check the latest MLB picksfor added insights.

At the center of Milwaukee’s strong push has been second baseman Brice Turang. The 25-year-old is putting together a breakout season, batting .368 with eight home runs and 20 RBIs across 19 games in August. His two-run homer on Thursday provided the spark to close out the series win over Chicago.

Quintana Anchors Elite Staff

Jose Quintana (10-4, 3.32 ERA) will start Friday for Milwaukee, adding experience to a pitching staff that owns MLB’s third-best ERA at 3.56. The veteran left-hander has gone 3-0 with a 2.70 ERA over his past four starts, showing the consistency the Brewers have relied on.

Quintana knows the Giants well from his earlier career. In eight outings against them, he has gone 2-4 with a 4.46 ERA. He last faced San Francisco on April 22, allowing one run across six innings in Milwaukee’s 11-3 victory. For more insight on this and other matchups, explore the MLB previews

Giants Facing Steep Climb

San Francisco enters the series in freefall, having lost 10 of its past 12 games. The Giants are now six games under .500 and 6 1/2 games out of the final National League wild-card slot. Their 9-22 record since the All-Star break has put their postseason chances on life support.

Despite the struggles, infielder Casey Schmitt believes the Giants are not out of the race. “It’s not crazy. Crazy things have happened, and we’re still definitely in it,” Schmitt said. For those analyzing fading teams like San Francisco, the expert MLB betting guide offers strategies on when to fade or back clubs in tough stretches.

Rookie Whisenhunt Returns to Rotation

Carson Whisenhunt (1-1, 5.02 ERA) gets the nod for the Giants to open the series. The 24-year-old rookie left-hander has made only three big league starts, most recently on Aug. 9 when he gave up three runs in four innings against the Nationals. After that outing, he was optioned to Triple-A before being recalled when Landen Roupp was placed on the injured list.

Whisenhunt’s numbers in the minors this season include a 9-5 record and a 4.37 ERA in 19 starts, but the Brewers’ offense presents a much steeper challenge. Bettors seeking added confidence in rookie vs. veteran pitching duels can look into buying expert picks to sharpen their wagering edge.

Betting Angle and Outlook

The Brewers are 24-8 since the All-Star break, while the Giants have continued to tumble. With Milwaukee’s balance between elite pitching and timely hitting, they enter the weekend with all the momentum. San Francisco, however, is desperate to avoid another series loss and must hope Whisenhunt can deliver a surprise performance.

Fans tracking expert predictions can compare records and performance on the best handicappers leaderboard before placing bets. And for a complete breakdown of how the game plays out, all MLB results will be updated once the series begins.