Minnesota Twins vs Chicago White Sox Picks and Predictions September 3, 2025

The Chicago White Sox travel to Target Field to face the Minnesota Twins in an AL Central matchup on Wednesday night. Chicago (51-88) rides a three-game win streak after a 12-3 blowout win over the Twins, while Minnesota (62-76) has dropped two straight and continues to fight inconsistency.

Bet Smarter with 100+ Picks a Day

Seriously. Just $9 to begin.

Join Now!

Oddsmakers list Minnesota as -169 favorites, Chicago at +143, with the total set at 8.5 runs. For how both teams have been trending, review the latest MLB game results.

Want smart MLB picks today? Check expert insights here →

White Sox Can Win If…

Their bats stay hot. Andrew Benintendi powered the offense Tuesday with a 4-for-5 night, two home runs, and five RBIs. Lenyn Sosa (19 HR) and Kyle Teel (.290 BA) add stability in the order, giving Chicago sneaky depth despite its record.

“We’re starting to see the lineup string things together,” manager Will Venable said after Tuesday’s victory.

On the mound, Yoendrys Gómez (5.20 ERA) hasn’t been sharp, but if he delivers quality innings, Chicago’s momentum can carry them to another upset win.

Twins Can Win If…

They get a bounce-back outing from Zebby Matthews and unleash their power bats. Matthews (5.06 ERA) has shown the ability to pitch into the middle innings, and the Twins need him to settle in early against Chicago’s streaking lineup.

“We’ve got to reset quickly and get back to what we do best—swinging with power,” Twins manager Rocco Baldelli said.

Minnesota ranks 12th in MLB in home runs (163), led by Byron Buxton (29 HR). Trevor Larnach and Carlos Correa can also provide big swings. If the bats get going behind Matthews, the Twins should be able to even the series.

Key MLB Betting Trends

The Lean

Pick: Twins -169
Projected Final Score: Twins 5, White Sox 4
Total Lean: Over 8.5 (-116)

Chicago’s recent surge makes them a live dog, but Minnesota’s power advantage and home field edge tilt the matchup. Expect runs on both sides with two shaky starters, making the Over the best play.

Stay ahead of the board with our daily MLB Moneyline Picks hub.

September baseball means playoff pushes—don’t miss your edge. See expert MLB picks here →