Minnesota Twins vs Cleveland Guardians Picks and Predictions May 21st 2025

Guardians and Twins Hope Weather Finally Cooperates in Minneapolis

After two consecutive days of rain delays, the Cleveland Guardians and Minnesota Twins are itching to get back on the field. With two games on the schedule for Wednesday, both teams are hoping the weather finally gives them a break — and a chance to shift the focus from forecasts to fastballs.

Back to Business After Suspended Opener

The first game on tap is a resumption of Monday’s suspended contest, set to pick up in the top of the fourth inning with Minnesota leading 2-1. The early damage came courtesy of RBIs from Ty France and Willi Castro for the Twins, while Cleveland’s Kyle Manzardo drove in a run before rain halted play.

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Joe Ryan (4-2, 2.42 ERA) will take over for Minnesota when the game resumes. The right-hander has been sharp all season and carries a 2.32 ERA across nine career starts against Cleveland. Bailey Ober handled the initial three innings before the downpour took over.

For the Guardians, it’ll be a bullpen effort to get through the final six innings. Logan Allen pitched the first three frames and will hand things off to a relief corps that has been tested throughout this rain-impacted series.

Game Two Brings New Arms and Opportunities

Following the conclusion of the suspended game, both teams will quickly gear up for their regularly scheduled matchup. The Twins will send Chris Paddack to the mound. He’s coming off two dominant starts — one against the Giants and another versus the Orioles — in which he allowed just one run over 14 1/3 combined innings.

Cleveland will counter with Gavin Williams (3-2, 4.29 ERA), who has been solid if unspectacular. He posted a no-decision in his last outing against Milwaukee and holds a 2-2 record with a 3.79 ERA in five career starts versus Minnesota.

For those eyeing MLB picks, the dynamic of a resumed game followed by a fresh one offers a unique challenge. Pitching depth and mid-game momentum could tip the scales in either direction, making this a betting situation worth monitoring closely.

Bats Starting to Warm Up

Minnesota third baseman Royce Lewis is slowly finding his rhythm after returning from injury. He’s batting just .205 overall but has gone 6-for-16 (.375) over his last four games, indicating he’s getting closer to full form.

“I feel like I just had my spring training. Those first 40 at-bats, I was just trying to get back, and I still have a long way to go.”
— Royce Lewis, Minnesota Twins

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Cleveland’s Steven Kwan continues to showcase his potential as a well-rounded hitter. Known for his plate discipline, Kwan has also flashed some unexpected pop with four home runs and 17 RBIs through 46 games.

“I profile myself as a patient guy, but sometimes just trying to go out and get a pitch and do some damage, I think that can be really effective.”
— Steven Kwan, Cleveland Guardians