Philadelphia Phillies vs Boston Red Sox Picks and Predictions July 21st 2025

Philadelphia Phillies vs Boston Red Sox MLB Mon, Jul 21, 17:45 pm.
Philadelphia Phillies
ML: -222
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Boston Red Sox
ML: 175
Last Updated on

The Boston Red Sox will take on the Philadelphia Phillies at Citizens Bank Park on Monday, July 21, 2025. The game is scheduled for 6:45 PM and will be broadcast on NSPPH. Fans can expect a warm evening with a clear sky and a light breeze.

Boston enters the game with a 54-47 record, sitting 5 games back in the AL East. On the mound, Walker Buehler will start for the Red Sox, holding a 6.12 ERA. The Phillies, with a 56-43 record, will have Zack Wheeler pitching. Wheeler has an ERA of 2.36, making him a strong presence at home with a 31-18 record.

Red Sox vs Phillies Key Information

  • Sport: Baseball
  • Teams: Boston Red Sox vs. Philadelphia Phillies
  • Venue: Citizens Bank Park in Philadelphia, PA
  • Date: Monday, July 21, 2025
  • Betting Odds: Red Sox Moneyline +173, Phillies Moneyline -206, Total Over 8.5 (-105), Total Under 8.5 (-115)

The Red Sox Can Win If…

The Boston Red Sox are coming off a strong win against the Chicago Cubs, winning 6-1. Garrett Crochet pitched well, allowing only one run over six innings. Wilyer Abreu and Alex Bregman led the offense with home runs, helping secure the victory.

The Red Sox have been performing well in several key stats this season. They rank first in doubles with 203 and fifth in both batting average (.254) and slugging percentage (.430). These numbers show their ability to hit for power and consistently get on base, which can be crucial in winning games.

Boston Red Sox player standing on the field during a game

Looking ahead, the Red Sox will rely on their strong lineup to continue their success. Players like Trevor Story and Wilyer Abreu have been consistent contributors. With Walker Buehler on the mound, the team hopes for a solid outing to support their potent offense against the Phillies.

The Phillies Can Win If…

The Philadelphia Phillies are set to bounce back after a recent loss to the Los Angeles Angels, where they fell 8-2. Otto Kemp was a standout in that game, hitting a home run and driving in one of the two runs. Despite the loss, the Phillies have shown they can hit for power, with Kemp and others capable of changing the game with one swing.

Philadelphia’s offense ranks 4th in batting average and on-base percentage this season. This shows their ability to get runners on base and create scoring opportunities. With key hitters like Kyle Schwarber and Bryce Harper leading the lineup, the Phillies have the firepower to put runs on the board.

Philadelphia Phillies player holding a bat during a game

Zack Wheeler will start for the Phillies, bringing an impressive 2.36 ERA into the game. His ability to keep hitters off balance and limit runs is a big advantage. With Wheeler on the mound, the Phillies have a strong chance to control the game and secure a win against the Boston Red Sox.

The Lean

The Phillies are favored with a moneyline of -206. My model projects a score of Phillies 5, Red Sox 3. The Phillies have a slightly better batting average and a stronger pitching staff, which supports taking them to win straight up.

The total for the game is set at 8.5. My model projects a total score of 8, suggesting a lean towards the under. Both teams have solid pitching, with the Phillies ranking 9th in ERA, which could keep the scoring lower than expected.

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Phillies and Red Sox Look to Find Rhythm After Sluggish Second-Half Starts

The Philadelphia Phillies return home looking to reset their momentum as they host the Boston Red Sox for a three-game interleague series starting Monday. Both teams stumbled out of the All-Star break and are eager to regain their footing in the playoff race.


Want an edge in this marquee matchup? Get the sharpest MLB expert picks and find the best betting value today.

Buehler Searching for Stability

Boston hands the ball to Walker Buehler (6-6, 6.12 ERA), who has endured a rocky return to the mound this season. After a brutal June in which he posted an 11.07 ERA, the veteran righty has shown signs of improvement in July.

He allowed two runs over five innings in a win against the Nationals on July 5, then followed with a six-inning, three-run effort against Tampa Bay.

“It’s nice to go through a week of prep, the five days or whatever, and not feel like I should just retire,” Buehler admitted. “You get into some really dark places and that’s what happens.”

Buehler has a mixed history against the Phillies, going 1-1 with a 6.48 ERA in four career appearances.

The Red Sox themselves had a sluggish restart after the break, dropping two straight to the Cubs before salvaging a 6-1 win on Sunday. Wilyer Abreu powered the offense with two home runs, snapping a 1-for-12 slump.

“He’s got a compact swing,” manager Alex Cora said. “There’s a few things he’s still working on… but we’ll take him every day in the outfield.”

Need to see if Boston’s lineup can stay hot? Check out our MLB Picks and Predictions for smart betting trends.

Wheeler Ready to Reset for Phillies

Philadelphia counters with Zack Wheeler (9-3, 2.36 ERA), one of the NL Cy Young frontrunners. Wheeler has been outstanding all season but is coming off one of his few rough outings, allowing four runs in six innings in a 5-4 loss to San Diego on July 12.

He skipped the All-Star Game to rest and prepare for the second half.

“Baseball is hard, and some days you’re gonna have days like today, and it stinks,” Wheeler said after the loss. “But it is baseball at the end of the day, and you’re in the big leagues, so you’ll get hit around a little bit sometimes. And it’s part of it.”

Wheeler has dominated Boston in the past, posting a 2-1 record with a 2.75 ERA in three career starts against them.

The Phillies dropped two of three against the Angels over the weekend, capped by an 8-2 defeat on Sunday. They managed just six hits in the finale, with rookie Otto Kemp providing the lone bright spot with a solo homer.

“I think we just had a lot of weak contact,” Kemp said of the team’s offensive struggles.


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With Buehler fighting to regain his form and Wheeler aiming to rebound from a rare misstep, Monday’s opener promises an intriguing pitching duel. Can the Phillies protect home field, or will Boston build on its latest win? See where the value lies with our updated MLB Predictions and Picks.