Pittsburgh Pirates vs Detroit Tigers Picks and Predictions July 22nd 2025

Pittsburgh Pirates vs Detroit Tigers MLB Tue, Jul 22, 17:40 pm.
Pittsburgh Pirates
ML: 125
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Detroit Tigers
ML: -154
Last Updated on

The Detroit Tigers will travel to PNC Park to play against the Pittsburgh Pirates on Tuesday, July 22, 2025. This night game will start at 6:40 PM and can be watched on SN PT. The weather forecast predicts a warm evening with clear skies and a calm crosswind.

Detroit Tigers, led by manager A.J. Hinch, have a strong season record of 60-41. They have done well on the road with a 28-23 record. The Pittsburgh Pirates, managed by Don Kelly, have a season record of 40-61 and are 20 games back in the NL Central. Casey Mize will start for the Tigers, while Mitch Keller takes the mound for the Pirates.

Tigers vs Pirates Key Information

  • Sport: Baseball
  • Teams: Detroit Tigers vs. Pittsburgh Pirates
  • Venue: PNC Park in Pittsburgh, PA
  • Date: Tuesday, July 22, 2025
  • Betting Odds: Tigers Moneyline -145, Pirates Moneyline +123, Tigers Runline -1.5 (+118), Pirates Runline +1.5 (-141), Total Over 8.0 (-108), Total Under 8.0 (-112)

The Tigers Can Win If…

The Detroit Tigers recently played against the Pittsburgh Pirates and lost 0-3. Jack Flaherty pitched three innings, allowing three runs and striking out six batters. Dillon Dingler, Parker Meadows, and Matt Vierling each contributed with a hit, but the team could not score.

The Tigers have a solid chance to win their next game thanks to some strong stats. Their team batting average is .249, ranking 10th, and they have hit 125 home runs, placing them 9th. On the pitching side, the team has an ERA of 3.69, which is 8th best, and they have recorded 865 strikeouts, ranking 7th.

Casey Mize will start for the Tigers, with an ERA of 3.15 and a 9-3 record. Mize’s consistent performance could be key in securing a win. The Tigers’ lineup, featuring players like Spencer Torkelson and Gleyber Torres, provides the potential for offensive production.

The Pirates Can Win If…

The Pittsburgh Pirates come into this game after a 3-0 win over the Detroit Tigers. Paul Skenes led the way with a strong performance, pitching six innings and allowing only three hits. Spencer Horwitz was key at the plate, going 3-for-4 with an RBI.

The Pirates’ pitching has been solid this season with a team ERA of 3.85, ranking 12th in the league. Their ability to keep opponents’ batting averages low, at .236, is a strength. Mitch Keller, with an ERA of 3.48, will start and aims to continue his consistent form.

Offensively, the Pirates rely on players like Andrew McCutchen and Ke’Bryan Hayes. McCutchen leads the team with eight home runs, while Hayes contributes with a .240 batting average. The Pirates also have speed on the bases, ranking 9th in stolen bases this season.

The Lean

The Tigers are favored with a moneyline of -145 against the Pirates at +123. The Tigers have a better batting average and on-base percentage, ranking 10th and 9th, respectively. With these stats, my model projects the Tigers to win 5-3. I recommend picking the Tigers to win straight up.

The total for the game is set at 8.0, with the over at -108 and the under at -112. The Tigers’ pitching has an ERA of 3.69, ranked 8th, while the Pirates have an ERA of 3.85, ranked 12th. My model projects a total score of 8 runs. I recommend taking the over for this game.

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A Duel of All-Stars: Casey Mize, Tigers Face Hot Mitch Keller and the Pirates

It is a fantastic pitching matchup in Pittsburgh on Tuesday night, featuring two right-handers with incredible stories. The visiting Detroit Tigers will send their new All-Star, Casey Mize, to the mound as he looks to bounce back against the Pittsburgh Pirates and their own dominant but unlucky ace, Mitch Keller.

A “Validating” Season for Mize

For Tigers starter Casey Mize (9-3, 3.15 ERA), this season has been a story of redemption. After a long recovery from Tommy John surgery, the former No. 1 overall pick has been brilliant, a performance that earned him his first career All-Star selection this week.

“It’s been a long journey,” Mize said. “I feel like this is pretty validating of some hard work and some tough times turning into success.” However, he is coming off his worst start of the season just before the break and will be looking for a strong rebound performance.

The Hard-Luck Ace

The Pirates will counter with their own ace, Mitch Keller (3-10, 3.48 ERA). Keller has been one of the hottest pitchers in baseball recently, posting a stellar 1.44 ERA over his last four starts. Despite his dominance, he has just three wins all season due to receiving the worst run support of any regular starting pitcher in the National League. His stellar performance has also made him a hot name in trade rumors. How to evaluate a hard-luck pitcher is a key topic in our expert betting guide.

Detroit’s Offensive Funk

Mize will need his offense to wake up to support him. The first-place Tigers are in the middle of their worst stretch of the season, a six-game losing streak. Their powerful offense has gone cold, scoring just three total runs in four games since the All-Star break. They were shut out 3-0 in the series opener on Monday.

The Pitching Duel

This game features a premier showdown on the mound between two of the best right-handers in the National and American Leagues. This duel will be the main event on the scores and odds board. For two MLB teams looking for a win, the focus will be on the starters. To see which ace our experts think will lead his team to victory, check out our daily MLB picks.