Pittsburgh Pirates vs Milwaukee Brewers Picks and Predictions September 6th 2025

Pittsburgh Pirates vs Milwaukee Brewers September 6th 2025

The Milwaukee Brewers will visit the Pittsburgh Pirates at PNC Park. The game is set for Saturday, September 6, 2025, at 6:40 PM. The Brewers lead the NL Central with an 87-55 record, while the Pirates sit in fifth place with a 64-78 record.

Brandon Woodruff will pitch for the Brewers. He holds a 5-2 record with a 3.69 ERA. Mitch Keller will take the mound for the Pirates, with a 6-13 record and a 4.21 ERA. The weather forecast calls for an overcast evening with a light breeze.

Brewers vs Pirates Key Information

• Sport: Baseball
• Teams: Milwaukee Brewers vs. Pittsburgh Pirates
• Venue: PNC Park in Pittsburgh, PA
• Date: Saturday, September 6, 2025
• Betting Odds: Brewers Moneyline -155, Pirates Moneyline +132

The Brewers Can Win If…

The Milwaukee Brewers enter this game with momentum from their recent 5-2 win against the Pittsburgh Pirates. Quinn Priester led the way with a strong performance, pitching seven innings and allowing just two runs. Jake Bauers also contributed by driving in two runs, helping the Brewers secure the victory.

The Brewers have been consistent at the plate this season, ranking second in both batting average (.259) and on-base percentage (.331). Their ability to get on base and create scoring opportunities is a key strength. Additionally, with 491 walks, they are fifth in the league, showing patience and discipline at the plate.

Brandon Woodruff will start for the Brewers, bringing a 3.69 ERA and a WHIP of 1.02. His ability to keep runners off base will be crucial against the Pirates. With a solid mix of pitching and hitting, the Brewers have a strong chance to win this game.

The Pirates Can Win If…

The Pittsburgh Pirates are looking to bounce back after a 5-2 loss to the Milwaukee Brewers. Despite the loss, Johan Oviedo had a strong outing, allowing only one hit and no earned runs in five innings. Oneil Cruz and Tommy Pham contributed with RBIs, showcasing their ability to drive in runs when needed.

Recent performances show the Pirates’ potential to win. They have a solid pitching staff with an ERA of 3.87, ranking them 8th in the league. This strong pitching, combined with their ability to keep opponents’ batting average low, gives them a good chance to secure a victory.

Andrew McCutchen and Bryan Reynolds lead the lineup with their batting skills. McCutchen has hit 13 home runs this season, while Reynolds has 15, making them key players to watch. With Mitch Keller on the mound, the Pirates have the tools to compete effectively in this game.

The Lean

The Brewers are favored with a moneyline of -155 against the Pirates, who have a moneyline of +132. The Brewers have a strong batting average and on-base percentage, both ranked 2nd in the league. Our model projects the Brewers to win with a score of 5-3, making them the pick to win straight up.

The total for the game is set at 8.0, with both the over and under at -110. The Brewers have a solid pitching staff with a 3.62 ERA, ranked 2nd in the league. The Pirates’ offense struggles, ranked 25th in slugging percentage. Our model projects a total score of 8, suggesting a push, so consider avoiding the total bet.

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Milwaukee Keeps Winning Despite Injuries

The Milwaukee Brewers continue to find ways to win even while battling injuries to their bullpen and lineup. With the best record in Major League Baseball, Milwaukee (87-55) is focused on locking down home-field advantage throughout the postseason.

On Friday, Quinn Priester delivered a strong outing and Jake Bauers filled in for Christian Yelich to drive in key runs during a 5-2 victory over the Pittsburgh Pirates. Priester secured his franchise-record 11th consecutive winning decision by pitching seven innings and allowing just two runs. His performance spared a short-handed bullpen that has been hit with multiple injuries, including Nick Mears landing on the 15-day injured list with lower back tightness.

Bauers, serving as designated hitter in place of Yelich, provided the go-ahead RBIs that proved decisive. The team’s depth has been a major storyline all season, with manager Pat Murphy crediting the players’ ability to step up in key moments.

Fans can follow more team breakdowns and matchup insights with the latest MLB previews

Woodruff Seeks to Rebound

Brandon Woodruff takes the mound Saturday looking to get back on track. The right-hander is 5-2 with a 3.69 ERA, but he has endured a tough stretch, going 1-2 with an 8.16 ERA over his past three starts. His most recent outing in Toronto saw him give up five earned runs on a season-high 10 hits in an 8-4 loss.

Woodruff’s struggles came immediately after a solid start against the Pirates on August 13, when he tossed four scoreless innings in a 12-5 Milwaukee win. Overall, he has posted a 7-3 record with a 3.25 ERA across 18 career appearances against Pittsburgh.

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Pirates Look to Spoil Brewers’ Momentum

The Pirates (64-78) came into the series on a high note after sweeping the Los Angeles Dodgers, but Friday’s loss to Milwaukee was a setback. Still, Pittsburgh remains dangerous in the role of spoiler against contending teams.

Mitch Keller will start Saturday’s game, entering with a 6-13 record and 4.21 ERA. He has dropped three of his past four starts, including a tough-luck outing against Boston in which he gave up no earned runs but still took the loss. When Keller faced Milwaukee on August 13, he was tagged for six runs on eight hits across four innings.

For bettors tracking form and situational edges, the expert MLB betting guide provides deeper angles into games like this one.

Roster Moves and Depth Adjustments

Milwaukee addressed its bullpen issues by recalling right-hander Carlos Rodriguez from Triple-A Nashville after placing Mears on the IL. Pittsburgh reinstated Kyle Nicolas from the bereavement list, and he contributed a scoreless inning on Friday. In a corresponding move, the Pirates optioned Cam Sanders back to Triple-A Indianapolis.

These depth changes continue to shape the outlook for both teams. For updated game-by-game performances and box scores, check the MLB results page

Betting Perspective

Milwaukee’s depth and ability to absorb injuries has been key all season, but the club will need Woodruff to find his form down the stretch. Pittsburgh, meanwhile, has shown it can play spoiler and may look to take advantage of Milwaukee’s recent starting pitching struggles.

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