San Diego Padres vs Arizona Diamondbacks Picks and Predictions September 27th 2025

San Diego Padres vs Arizona Diamondbacks Baseball Sat, Sep 27, 19:40 pm.
San Diego Padres
ML: -150
0
0
Arizona Diamondbacks
ML: 120
Last Updated on

San Diego Padres vs Arizona Diamondbacks Betting Preview

The San Diego Padres continue their playoff push Saturday at PETCO Park against the Arizona Diamondbacks. San Diego (88-72) sits two games back of the Cubs in the NL wild-card standings and needs help to secure home-field advantage in their upcoming series. Arizona (80-80) was officially eliminated Friday after San Diego’s 7-4 win, highlighted by a Fernando Tatis Jr. grand slam.

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Odds and Market Movement

  • Moneyline: Diamondbacks +119 | Padres -141
  • Runline: Diamondbacks +1.5 (-155) | Padres -1.5 (+130)
  • Total: Over 7.5 (-108) | Under 7.5 (-112)

San Diego opened as a slight favorite, and betting action has kept them steady at around -140.

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Matchup Breakdown

Diamondbacks Outlook

Arizona’s offense has been inconsistent, but their power numbers still rank among the league’s best. With a .433 slugging percentage and 272 doubles (4th in MLB), players like Corbin Carroll and Ketel Marte remain threats to change a game with one swing.

Eduardo Rodriguez (9-8, 4.91 ERA) will start, coming off six scoreless innings against Philadelphia. He’s pitched well historically vs. San Diego (2.30 ERA in three starts), but Arizona’s bullpen has been a disaster — 29 blown saves this year, including eight in the ninth inning, both league worsts.

Padres Outlook

San Diego is looking to stay sharp heading into October. Michael King (5-3, 3.57 ERA) gets the nod after tossing five shutout frames vs. the White Sox last week. He’s been excellent against Arizona in his career, with 11 scoreless innings over two starts.

Offensively, Fernando Tatis Jr. made his return in a big way Friday with a grand slam. He’s joined by Manny Machado (26 HR, 93 RBI) and Luis Arraez, who continues to provide on-base consistency. The Padres’ pitching staff leads MLB in batting average against (.224) and sits 3rd in ERA (3.65).

Key Battle

The Diamondbacks’ power bats vs. San Diego’s elite pitching. Arizona has punished mistakes, but King’s ability to keep the ball down and the Padres’ bullpen depth could tilt the balance late.

Injuries and Conditions

San Diego PadresArizona Diamondbacks
• SP Yu Darvish (elbow) 60-day IL• RP Paul Sewald (shoulder) out
• RP Robert Suarez (lat) questionable• OF Jake McCarthy (oblique) out
• OF Jackson Merrill (hamstring) day-to-day• SP Merrill Kelly (back) 60-day IL

Weather: Mild evening at PETCO Park with a light breeze and scattered clouds. Ideal conditions for baseball.

Best Bets and Prediction

San Diego’s superior pitching and Arizona’s late-inning struggles make the Padres the logical side here. Rodriguez can keep it close early, but the Padres’ bats have the advantage.

  • Pick: Padres ML -141
  • Projected Score: Padres 5, Diamondbacks 3
  • Reasoning: King shuts down Arizona lineup, Padres’ depth provides timely runs.
  • Lean: Under 7.5 (-112)
CategoryDetail
Best BetPadres ML -141
Confidence★★★★☆
Projected ScorePadres 5, Diamondbacks 3
Total LeanUnder 7.5 (-112)
Market Split59% bets Padres, 55% money Under

Handicappers and Picks

Handicappers are circling this series as a potential trap spot — with San Diego possibly scoreboard-watching the Cubs. But historical trends back them: the Padres are 11-4 in their last 15 vs. Arizona at PETCO.

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