San Diego Padres vs Milwaukee Brewers Picks and Predictions September 24th 2025

San Diego Padres vs Milwaukee Brewers September 24th 2025

The Milwaukee Brewers, with a record of 95-62, will visit the San Diego Padres at PETCO Park. The Brewers are leading the NL Central Division but have lost their last two games. The Padres, holding an 86-71 record, are second in the NL West and are on a three-game winning streak.

This game will feature Brewers’ starter Quinn Priester, who has a 3.25 ERA and a 13-2 record. The Padres will counter with Dylan Cease, who has a 4.64 ERA and an 8-12 record. The game is scheduled for Wednesday, September 24, 2025, at 4:10 PM, with clear skies and a light breeze expected.

Brewers vs Padres Key Information

• Sport: Baseball
• Teams: Milwaukee Brewers vs. San Diego Padres
• Venue: PETCO Park in San Diego, CA
• Date: Wednesday, September 24, 2025
• Betting Odds: Brewers Moneyline +108, Padres Moneyline -126

The Brewers Can Win If…

The Milwaukee Brewers are looking to bounce back after a tough 7-0 loss to the San Diego Padres. In that game, Christian Yelich managed one hit in four at-bats, while Bruce Zimmermann pitched six innings but allowed six runs. Despite the loss, the Brewers have shown they can compete against strong teams.

The Brewers have a solid team batting average of .260, ranking second in the league. Their on-base percentage is the best in the league at .332, which means they have a knack for getting on base. With Quinn Priester on the mound, who has a 3.25 ERA and a 13-2 record, they have a strong chance to control the game.

Brice Turang, with a batting average of .286 and 18 home runs, leads the lineup. Christian Yelich, who has 29 home runs and 102 RBIs, is another key player. With a lineup full of capable hitters, the Brewers have the tools to put pressure on the Padres’ pitching staff.

The Padres Can Win If…

The San Diego Padres recently dominated the Milwaukee Brewers with a 7-0 win. Randy Vásquez pitched seven innings, allowing just one hit and no runs. The offense was powered by home runs from Luis Arraez, Ryan O’Hearn, and Jose Iglesias, showcasing their ability to score big.

The Padres have strong batting stats that can lead them to victory. They hold a team batting average of .252, ranking 6th in the league. With a solid on-base percentage of .318, they consistently put runners on base, creating scoring opportunities.

The Padres’ pitching staff is a key reason they can win. They have the best batting average against at .225, limiting opponents’ chances to score. Their earned run average of 3.68 ranks 3rd, showing their ability to keep games close and give their offense a chance to win.

Latest Betting Trends

• San Diego has won four of its last five home games, strengthening its wild-card case.
• The Padres are 3-1 in Dylan Cease’s last four starts at Petco Park.
• Milwaukee has dropped four of its last five overall, but remains steady on the road with a winning record.
• The Brewers have hit the under in three of their past four matchups.

The Lean

The Padres are favored with a moneyline of -126, while the Brewers have a moneyline of +108. The Padres have a slight edge in team batting and pitching stats, ranking higher in batting average and on-base percentage. My model projects the Padres to win 4-3, making the Padres the recommended pick for the moneyline.

The total for the game is set at 7.5 runs, with the over at -111 and the under at -109. Both teams have strong pitching, with the Padres having the best batting average against. My model projects a total score of 7 runs, suggesting the under is the better pick.

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Padres and Brewers Continue to Battle for Playoff Position

San Diego Padres manager Mike Shildt is juggling multiple priorities as the final week of the regular season unfolds. The Padres are still chasing both the Chicago Cubs and Los Angeles Dodgers in hopes of securing homefield advantage, while also looking to rest key contributors for what they hope will be a deep postseason run.

A 7-0 victory over the Milwaukee Brewers on Tuesday night provided a valuable boost. Combined with losses by both Chicago and Los Angeles, the win pushed San Diego (87-71) within 1.5 games of the Cubs for the top wild-card spot and 1.5 games of the Dodgers in the NL West. It also allowed Shildt to give Manny Machado, Jackson Merrill, Jake Cronenworth, and Fernando Tatis Jr. a break. Tatis missed his second straight game with an illness, raising some concerns about his availability going forward.

Fans tracking the playoff race can follow updated MLB previews and expert betting analysis to see how the Padres’ push impacts odds.

Padres Turn to Dylan Cease

San Diego hands the ball to Dylan Cease (8-12, 4.64 ERA) in what could be his last regular-season start for the franchise before free agency. Cease is coming off a 4-3 loss against the Chicago White Sox, where he allowed four runs across six innings. He has posted a 3.57 ERA in three career starts against Milwaukee, and his outing will be a key test as the Padres look to sustain momentum.

For bettors watching closely, the Padres’ results can be tracked through updated MLB game results and daily picks heading into the final stretch.

Brewers Shuffle the Rotation

The Brewers (95-63) made a late pitching change, sending rookie right-hander Chad Patrick (3-8, 3.66 ERA) to the mound instead of Quinn Priester, who is now lined up to start Friday against the Cincinnati Reds. Patrick pitched on Saturday, giving up two runs over 4 1/3 innings in a no-decision against St. Louis. His lone career start against San Diego came back on June 6, when he surrendered just one run across six innings but was tagged with a 2-0 loss.

Despite dropping four of their last five games, Milwaukee remains 2.5 games ahead of Philadelphia for NL playoff homefield advantage. For those seeking sharper insights into how the Brewers’ playoff positioning could impact betting, the Sports Hub leaderboard and buy picks section highlight where the experts are leaning.

Preparing for October

The Brewers are also taking a long view toward the postseason. All-Star closer Trevor Megill and veteran Jose Quintana worked bullpen sessions Tuesday, while Logan Henderson and DL Hall are preparing in Arizona for potential NLDS roster spots.

Pitching coach Chris Hook remained upbeat despite uncertainty, noting that navigating challenges has become part of the team’s normal routine. As the Brewers eye October, balancing readiness with health remains their central focus.

Stay updated with the latest MLB betting guides and previews to track playoff implications and wagering angles down the stretch.